Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development
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Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development. / Tolosa, E; Ashwell, J D.
In: NEUROIMMUNOMODULAT, Vol. 6, No. 1-2, 1999, p. 90-6.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development
AU - Tolosa, E
AU - Ashwell, J D
PY - 1999
Y1 - 1999
N2 - Bidirectional interactions of both a stimulatory and inhibitory nature occur between the neuroendocrine and the immune systems, and these interactions play an important modulatory role during T-cell ontogeny. Specifically, glucocorticoids potently induce apoptosis in thymocytes and activated T cells, but can also rescue these cells from activation-induced cell death. The objective of this review is to discuss current data on the interactions of the immune system with steroid hormones in the thymus and to describe a model that includes glucocorticoids in the shaping of the peripheral T-cell antigen-specific repertoire and deals with their potential role in the generation of autoimmune disease.
AB - Bidirectional interactions of both a stimulatory and inhibitory nature occur between the neuroendocrine and the immune systems, and these interactions play an important modulatory role during T-cell ontogeny. Specifically, glucocorticoids potently induce apoptosis in thymocytes and activated T cells, but can also rescue these cells from activation-induced cell death. The objective of this review is to discuss current data on the interactions of the immune system with steroid hormones in the thymus and to describe a model that includes glucocorticoids in the shaping of the peripheral T-cell antigen-specific repertoire and deals with their potential role in the generation of autoimmune disease.
KW - Animals
KW - Apoptosis
KW - Glucocorticoids
KW - Gonadal Steroid Hormones
KW - Humans
KW - Immune System
KW - Steroids
KW - T-Lymphocytes
KW - Thymus Gland
M3 - SCORING: Journal article
C2 - 9876239
VL - 6
SP - 90
EP - 96
JO - NEUROIMMUNOMODULAT
JF - NEUROIMMUNOMODULAT
SN - 1021-7401
IS - 1-2
ER -