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Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development

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Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development. / Tolosa, E; Ashwell, J D.

in: NEUROIMMUNOMODULAT, Jahrgang 6, Nr. 1-2, 1999, S. 90-6.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tolosa, E & Ashwell, JD 1999, 'Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development', NEUROIMMUNOMODULAT, Jg. 6, Nr. 1-2, S. 90-6.

APA

Tolosa, E., & Ashwell, J. D. (1999). Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development. NEUROIMMUNOMODULAT, 6(1-2), 90-6.

Vancouver

Tolosa E, Ashwell JD. Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development. NEUROIMMUNOMODULAT. 1999;6(1-2):90-6.

Bibtex

@article{2690eae289ad4e7395d902e028e40a20,
title = "Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development",
abstract = "Bidirectional interactions of both a stimulatory and inhibitory nature occur between the neuroendocrine and the immune systems, and these interactions play an important modulatory role during T-cell ontogeny. Specifically, glucocorticoids potently induce apoptosis in thymocytes and activated T cells, but can also rescue these cells from activation-induced cell death. The objective of this review is to discuss current data on the interactions of the immune system with steroid hormones in the thymus and to describe a model that includes glucocorticoids in the shaping of the peripheral T-cell antigen-specific repertoire and deals with their potential role in the generation of autoimmune disease.",
keywords = "Animals, Apoptosis, Glucocorticoids, Gonadal Steroid Hormones, Humans, Immune System, Steroids, T-Lymphocytes, Thymus Gland",
author = "E Tolosa and Ashwell, {J D}",
year = "1999",
language = "English",
volume = "6",
pages = "90--6",
journal = "NEUROIMMUNOMODULAT",
issn = "1021-7401",
publisher = "S. Karger AG",
number = "1-2",

}

RIS

TY - JOUR

T1 - Thymus-derived glucocorticoids and the regulation of antigen-specific T-cell development

AU - Tolosa, E

AU - Ashwell, J D

PY - 1999

Y1 - 1999

N2 - Bidirectional interactions of both a stimulatory and inhibitory nature occur between the neuroendocrine and the immune systems, and these interactions play an important modulatory role during T-cell ontogeny. Specifically, glucocorticoids potently induce apoptosis in thymocytes and activated T cells, but can also rescue these cells from activation-induced cell death. The objective of this review is to discuss current data on the interactions of the immune system with steroid hormones in the thymus and to describe a model that includes glucocorticoids in the shaping of the peripheral T-cell antigen-specific repertoire and deals with their potential role in the generation of autoimmune disease.

AB - Bidirectional interactions of both a stimulatory and inhibitory nature occur between the neuroendocrine and the immune systems, and these interactions play an important modulatory role during T-cell ontogeny. Specifically, glucocorticoids potently induce apoptosis in thymocytes and activated T cells, but can also rescue these cells from activation-induced cell death. The objective of this review is to discuss current data on the interactions of the immune system with steroid hormones in the thymus and to describe a model that includes glucocorticoids in the shaping of the peripheral T-cell antigen-specific repertoire and deals with their potential role in the generation of autoimmune disease.

KW - Animals

KW - Apoptosis

KW - Glucocorticoids

KW - Gonadal Steroid Hormones

KW - Humans

KW - Immune System

KW - Steroids

KW - T-Lymphocytes

KW - Thymus Gland

M3 - SCORING: Journal article

C2 - 9876239

VL - 6

SP - 90

EP - 96

JO - NEUROIMMUNOMODULAT

JF - NEUROIMMUNOMODULAT

SN - 1021-7401

IS - 1-2

ER -