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The tumor cell-host organ interface in the early onset of metastatic organ colonisation

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The tumor cell-host organ interface in the early onset of metastatic organ colonisation. / Gassmann, Peter; Haier, Joerg.

In: CLIN EXP METASTAS, Vol. 25, No. 2, 2008, p. 171-81.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gassmann, P & Haier, J 2008, 'The tumor cell-host organ interface in the early onset of metastatic organ colonisation', CLIN EXP METASTAS, vol. 25, no. 2, pp. 171-81. https://doi.org/10.1007/s10585-007-9130-6

APA

Gassmann, P., & Haier, J. (2008). The tumor cell-host organ interface in the early onset of metastatic organ colonisation. CLIN EXP METASTAS, 25(2), 171-81. https://doi.org/10.1007/s10585-007-9130-6

Vancouver

Gassmann P, Haier J. The tumor cell-host organ interface in the early onset of metastatic organ colonisation. CLIN EXP METASTAS. 2008;25(2):171-81. https://doi.org/10.1007/s10585-007-9130-6

Bibtex

@article{0adc0e19f0bd409d98f3dfb3e438ddb0,
title = "The tumor cell-host organ interface in the early onset of metastatic organ colonisation",
abstract = "Metastatic lesions are the leading cause of death among cancer patients. These lesions usually originate from clonal proliferation of single tumor cells dispersed from the primary tumor into the circulation which finally arrest in the capillary bed of distant organs. The microenvironment within the circulation of potential metastatic target organs provides a variety of pro- and anti- metastatic stimuli regulating the onset of organ colonisation by metastatic tumor cells. Mechanical shear stress, anoikis and cell mediated cytotoxicity within the microcirculation probably clear most circulating tumor cells. Adhesion, and eventually extravasation, are essential initial interactions of circulating tumor cells with distant organs and can provide escape from the cytotoxic environment within the circulation. Adhesion to the capillary wall is mostly controlled by the organ-specific availability of adhesion molecules on tumor cells, the endothelium, and the composition of the underlying extracellular matrix. The availability of pro-adhesive and pro-migratory paracrine signals provided by the organ specific microenvironment can further initiate the onset of metastatic organ colonisation. Tumor cell and microenvironment factors regulating survival within the microcirculation, adhesion and extravasation of tumor cells are highlighted in the review.",
keywords = "Cell Adhesion, Cell Movement, Chemokines, Endothelial Cells, Endothelium, Vascular, Extracellular Matrix, Humans, Killer Cells, Natural, Kupffer Cells, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplastic Cells, Circulating",
author = "Peter Gassmann and Joerg Haier",
year = "2008",
doi = "10.1007/s10585-007-9130-6",
language = "English",
volume = "25",
pages = "171--81",
journal = "CLIN EXP METASTAS",
issn = "0262-0898",
publisher = "Springer Netherlands",
number = "2",

}

RIS

TY - JOUR

T1 - The tumor cell-host organ interface in the early onset of metastatic organ colonisation

AU - Gassmann, Peter

AU - Haier, Joerg

PY - 2008

Y1 - 2008

N2 - Metastatic lesions are the leading cause of death among cancer patients. These lesions usually originate from clonal proliferation of single tumor cells dispersed from the primary tumor into the circulation which finally arrest in the capillary bed of distant organs. The microenvironment within the circulation of potential metastatic target organs provides a variety of pro- and anti- metastatic stimuli regulating the onset of organ colonisation by metastatic tumor cells. Mechanical shear stress, anoikis and cell mediated cytotoxicity within the microcirculation probably clear most circulating tumor cells. Adhesion, and eventually extravasation, are essential initial interactions of circulating tumor cells with distant organs and can provide escape from the cytotoxic environment within the circulation. Adhesion to the capillary wall is mostly controlled by the organ-specific availability of adhesion molecules on tumor cells, the endothelium, and the composition of the underlying extracellular matrix. The availability of pro-adhesive and pro-migratory paracrine signals provided by the organ specific microenvironment can further initiate the onset of metastatic organ colonisation. Tumor cell and microenvironment factors regulating survival within the microcirculation, adhesion and extravasation of tumor cells are highlighted in the review.

AB - Metastatic lesions are the leading cause of death among cancer patients. These lesions usually originate from clonal proliferation of single tumor cells dispersed from the primary tumor into the circulation which finally arrest in the capillary bed of distant organs. The microenvironment within the circulation of potential metastatic target organs provides a variety of pro- and anti- metastatic stimuli regulating the onset of organ colonisation by metastatic tumor cells. Mechanical shear stress, anoikis and cell mediated cytotoxicity within the microcirculation probably clear most circulating tumor cells. Adhesion, and eventually extravasation, are essential initial interactions of circulating tumor cells with distant organs and can provide escape from the cytotoxic environment within the circulation. Adhesion to the capillary wall is mostly controlled by the organ-specific availability of adhesion molecules on tumor cells, the endothelium, and the composition of the underlying extracellular matrix. The availability of pro-adhesive and pro-migratory paracrine signals provided by the organ specific microenvironment can further initiate the onset of metastatic organ colonisation. Tumor cell and microenvironment factors regulating survival within the microcirculation, adhesion and extravasation of tumor cells are highlighted in the review.

KW - Cell Adhesion

KW - Cell Movement

KW - Chemokines

KW - Endothelial Cells

KW - Endothelium, Vascular

KW - Extracellular Matrix

KW - Humans

KW - Killer Cells, Natural

KW - Kupffer Cells

KW - Neoplasm Invasiveness

KW - Neoplasm Metastasis

KW - Neoplastic Cells, Circulating

U2 - 10.1007/s10585-007-9130-6

DO - 10.1007/s10585-007-9130-6

M3 - SCORING: Journal article

C2 - 18058027

VL - 25

SP - 171

EP - 181

JO - CLIN EXP METASTAS

JF - CLIN EXP METASTAS

SN - 0262-0898

IS - 2

ER -