The tumor cell-host organ interface in the early onset of metastatic organ colonisation
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The tumor cell-host organ interface in the early onset of metastatic organ colonisation. / Gassmann, Peter; Haier, Joerg.
in: CLIN EXP METASTAS, Jahrgang 25, Nr. 2, 2008, S. 171-81.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The tumor cell-host organ interface in the early onset of metastatic organ colonisation
AU - Gassmann, Peter
AU - Haier, Joerg
PY - 2008
Y1 - 2008
N2 - Metastatic lesions are the leading cause of death among cancer patients. These lesions usually originate from clonal proliferation of single tumor cells dispersed from the primary tumor into the circulation which finally arrest in the capillary bed of distant organs. The microenvironment within the circulation of potential metastatic target organs provides a variety of pro- and anti- metastatic stimuli regulating the onset of organ colonisation by metastatic tumor cells. Mechanical shear stress, anoikis and cell mediated cytotoxicity within the microcirculation probably clear most circulating tumor cells. Adhesion, and eventually extravasation, are essential initial interactions of circulating tumor cells with distant organs and can provide escape from the cytotoxic environment within the circulation. Adhesion to the capillary wall is mostly controlled by the organ-specific availability of adhesion molecules on tumor cells, the endothelium, and the composition of the underlying extracellular matrix. The availability of pro-adhesive and pro-migratory paracrine signals provided by the organ specific microenvironment can further initiate the onset of metastatic organ colonisation. Tumor cell and microenvironment factors regulating survival within the microcirculation, adhesion and extravasation of tumor cells are highlighted in the review.
AB - Metastatic lesions are the leading cause of death among cancer patients. These lesions usually originate from clonal proliferation of single tumor cells dispersed from the primary tumor into the circulation which finally arrest in the capillary bed of distant organs. The microenvironment within the circulation of potential metastatic target organs provides a variety of pro- and anti- metastatic stimuli regulating the onset of organ colonisation by metastatic tumor cells. Mechanical shear stress, anoikis and cell mediated cytotoxicity within the microcirculation probably clear most circulating tumor cells. Adhesion, and eventually extravasation, are essential initial interactions of circulating tumor cells with distant organs and can provide escape from the cytotoxic environment within the circulation. Adhesion to the capillary wall is mostly controlled by the organ-specific availability of adhesion molecules on tumor cells, the endothelium, and the composition of the underlying extracellular matrix. The availability of pro-adhesive and pro-migratory paracrine signals provided by the organ specific microenvironment can further initiate the onset of metastatic organ colonisation. Tumor cell and microenvironment factors regulating survival within the microcirculation, adhesion and extravasation of tumor cells are highlighted in the review.
KW - Cell Adhesion
KW - Cell Movement
KW - Chemokines
KW - Endothelial Cells
KW - Endothelium, Vascular
KW - Extracellular Matrix
KW - Humans
KW - Killer Cells, Natural
KW - Kupffer Cells
KW - Neoplasm Invasiveness
KW - Neoplasm Metastasis
KW - Neoplastic Cells, Circulating
U2 - 10.1007/s10585-007-9130-6
DO - 10.1007/s10585-007-9130-6
M3 - SCORING: Journal article
C2 - 18058027
VL - 25
SP - 171
EP - 181
JO - CLIN EXP METASTAS
JF - CLIN EXP METASTAS
SN - 0262-0898
IS - 2
ER -