Research ExplorerPublicationsThe Translational Landscape of the Human Heart

The Translational Landscape of the Human Heart

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The Translational Landscape of the Human Heart. / van Heesch, Sebastiaan; Witte, Franziska; Schneider-Lunitz, Valentin; Schulz, Jana F; Adami, Eleonora; Faber, Allison B; Kirchner, Marieluise; Maatz, Henrike; Blachut, Susanne; Sandmann, Clara-Louisa; Kanda, Masatoshi; Worth, Catherine L; Schafer, Sebastian; Calviello, Lorenzo; Merriott, Rhys; Patone, Giannino; Hummel, Oliver; Wyler, Emanuel; Obermayer, Benedikt; Mücke, Michael B; Lindberg, Eric L; Trnka, Franziska; Memczak, Sebastian; Schilling, Marcel; Felkin, Leanne E; Barton, Paul J R; Quaife, Nicholas M; Vanezis, Konstantinos; Diecke, Sebastian; Mukai, Masaya; Mah, Nancy; Oh, Su-Jun; Kurtz, Andreas; Schramm, Christoph; Schwinge, Dorothee; Sebode, Marcial; Harakalova, Magdalena; Asselbergs, Folkert W; Vink, Aryan; de Weger, Roel A; Viswanathan, Sivakumar; Widjaja, Anissa A; Gärtner-Rommel, Anna; Milting, Hendrik; Dos Remedios, Cris; Knosalla, Christoph; Mertins, Philipp; Landthaler, Markus; Vingron, Martin; Linke, Wolfgang A; Seidman, Jonathan G; Seidman, Christine E; Rajewsky, Nikolaus; Ohler, Uwe; Cook, Stuart A; Hubner, Norbert.

In: CELL, Vol. 178, No. 1, 27.06.2019, p. 242-260.e29.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

van Heesch, S, Witte, F, Schneider-Lunitz, V, Schulz, JF, Adami, E, Faber, AB, Kirchner, M, Maatz, H, Blachut, S, Sandmann, C-L, Kanda, M, Worth, CL, Schafer, S, Calviello, L, Merriott, R, Patone, G, Hummel, O, Wyler, E, Obermayer, B, Mücke, MB, Lindberg, EL, Trnka, F, Memczak, S, Schilling, M, Felkin, LE, Barton, PJR, Quaife, NM, Vanezis, K, Diecke, S, Mukai, M, Mah, N, Oh, S-J, Kurtz, A, Schramm, C, Schwinge, D, Sebode, M, Harakalova, M, Asselbergs, FW, Vink, A, de Weger, RA, Viswanathan, S, Widjaja, AA, Gärtner-Rommel, A, Milting, H, Dos Remedios, C, Knosalla, C, Mertins, P, Landthaler, M, Vingron, M, Linke, WA, Seidman, JG, Seidman, CE, Rajewsky, N, Ohler, U, Cook, SA & Hubner, N 2019, 'The Translational Landscape of the Human Heart', CELL, vol. 178, no. 1, pp. 242-260.e29. https://doi.org/10.1016/j.cell.2019.05.010

APA

van Heesch, S., Witte, F., Schneider-Lunitz, V., Schulz, J. F., Adami, E., Faber, A. B., Kirchner, M., Maatz, H., Blachut, S., Sandmann, C-L., Kanda, M., Worth, C. L., Schafer, S., Calviello, L., Merriott, R., Patone, G., Hummel, O., Wyler, E., Obermayer, B., ... Hubner, N. (2019). The Translational Landscape of the Human Heart. CELL, 178(1), 242-260.e29. https://doi.org/10.1016/j.cell.2019.05.010

Vancouver

van Heesch S, Witte F, Schneider-Lunitz V, Schulz JF, Adami E, Faber AB et al. The Translational Landscape of the Human Heart. CELL. 2019 Jun 27;178(1):242-260.e29. https://doi.org/10.1016/j.cell.2019.05.010

Bibtex

@article{b62278fa49b34d0cbc48950d90023d25,
title = "The Translational Landscape of the Human Heart",
abstract = "Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. We show extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner. Translation downstream of predicted disease-causing protein-truncating variants appears to be frequent, suggesting inefficient translation termination. We identify hundreds of previously undetected microproteins, expressed from lncRNAs and circRNAs, for which we validate the protein products in vivo. The translation of microproteins is not restricted to the heart and prominent in the translatomes of human kidney and liver. We associate these microproteins with diverse cellular processes and compartments and find that many locate to the mitochondria. Importantly, dozens of microproteins are translated from lncRNAs with well-characterized noncoding functions, indicating previously unrecognized biology.",
keywords = "Journal Article",
author = "{van Heesch}, Sebastiaan and Franziska Witte and Valentin Schneider-Lunitz and Schulz, {Jana F} and Eleonora Adami and Faber, {Allison B} and Marieluise Kirchner and Henrike Maatz and Susanne Blachut and Clara-Louisa Sandmann and Masatoshi Kanda and Worth, {Catherine L} and Sebastian Schafer and Lorenzo Calviello and Rhys Merriott and Giannino Patone and Oliver Hummel and Emanuel Wyler and Benedikt Obermayer and M{\"u}cke, {Michael B} and Lindberg, {Eric L} and Franziska Trnka and Sebastian Memczak and Marcel Schilling and Felkin, {Leanne E} and Barton, {Paul J R} and Quaife, {Nicholas M} and Konstantinos Vanezis and Sebastian Diecke and Masaya Mukai and Nancy Mah and Su-Jun Oh and Andreas Kurtz and Christoph Schramm and Dorothee Schwinge and Marcial Sebode and Magdalena Harakalova and Asselbergs, {Folkert W} and Aryan Vink and {de Weger}, {Roel A} and Sivakumar Viswanathan and Widjaja, {Anissa A} and Anna G{\"a}rtner-Rommel and Hendrik Milting and {Dos Remedios}, Cris and Christoph Knosalla and Philipp Mertins and Markus Landthaler and Martin Vingron and Linke, {Wolfgang A} and Seidman, {Jonathan G} and Seidman, {Christine E} and Nikolaus Rajewsky and Uwe Ohler and Cook, {Stuart A} and Norbert Hubner",
note = "Copyright {\textcopyright} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
month = jun,
day = "27",
doi = "10.1016/j.cell.2019.05.010",
language = "English",
volume = "178",
pages = "242--260.e29",
journal = "CELL",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - The Translational Landscape of the Human Heart

AU - van Heesch, Sebastiaan

AU - Witte, Franziska

AU - Schneider-Lunitz, Valentin

AU - Schulz, Jana F

AU - Adami, Eleonora

AU - Faber, Allison B

AU - Kirchner, Marieluise

AU - Maatz, Henrike

AU - Blachut, Susanne

AU - Sandmann, Clara-Louisa

AU - Kanda, Masatoshi

AU - Worth, Catherine L

AU - Schafer, Sebastian

AU - Calviello, Lorenzo

AU - Merriott, Rhys

AU - Patone, Giannino

AU - Hummel, Oliver

AU - Wyler, Emanuel

AU - Obermayer, Benedikt

AU - Mücke, Michael B

AU - Lindberg, Eric L

AU - Trnka, Franziska

AU - Memczak, Sebastian

AU - Schilling, Marcel

AU - Felkin, Leanne E

AU - Barton, Paul J R

AU - Quaife, Nicholas M

AU - Vanezis, Konstantinos

AU - Diecke, Sebastian

AU - Mukai, Masaya

AU - Mah, Nancy

AU - Oh, Su-Jun

AU - Kurtz, Andreas

AU - Schramm, Christoph

AU - Schwinge, Dorothee

AU - Sebode, Marcial

AU - Harakalova, Magdalena

AU - Asselbergs, Folkert W

AU - Vink, Aryan

AU - de Weger, Roel A

AU - Viswanathan, Sivakumar

AU - Widjaja, Anissa A

AU - Gärtner-Rommel, Anna

AU - Milting, Hendrik

AU - Dos Remedios, Cris

AU - Knosalla, Christoph

AU - Mertins, Philipp

AU - Landthaler, Markus

AU - Vingron, Martin

AU - Linke, Wolfgang A

AU - Seidman, Jonathan G

AU - Seidman, Christine E

AU - Rajewsky, Nikolaus

AU - Ohler, Uwe

AU - Cook, Stuart A

AU - Hubner, Norbert

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019/6/27

Y1 - 2019/6/27

N2 - Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. We show extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner. Translation downstream of predicted disease-causing protein-truncating variants appears to be frequent, suggesting inefficient translation termination. We identify hundreds of previously undetected microproteins, expressed from lncRNAs and circRNAs, for which we validate the protein products in vivo. The translation of microproteins is not restricted to the heart and prominent in the translatomes of human kidney and liver. We associate these microproteins with diverse cellular processes and compartments and find that many locate to the mitochondria. Importantly, dozens of microproteins are translated from lncRNAs with well-characterized noncoding functions, indicating previously unrecognized biology.

AB - Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. We show extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner. Translation downstream of predicted disease-causing protein-truncating variants appears to be frequent, suggesting inefficient translation termination. We identify hundreds of previously undetected microproteins, expressed from lncRNAs and circRNAs, for which we validate the protein products in vivo. The translation of microproteins is not restricted to the heart and prominent in the translatomes of human kidney and liver. We associate these microproteins with diverse cellular processes and compartments and find that many locate to the mitochondria. Importantly, dozens of microproteins are translated from lncRNAs with well-characterized noncoding functions, indicating previously unrecognized biology.

KW - Journal Article

U2 - 10.1016/j.cell.2019.05.010

DO - 10.1016/j.cell.2019.05.010

M3 - SCORING: Journal article

C2 - 31155234

VL - 178

SP - 242-260.e29

JO - CELL

JF - CELL

SN - 0092-8674

IS - 1

ER -