The Translational Landscape of the Human Heart
Standard
The Translational Landscape of the Human Heart. / van Heesch, Sebastiaan; Witte, Franziska; Schneider-Lunitz, Valentin; Schulz, Jana F; Adami, Eleonora; Faber, Allison B; Kirchner, Marieluise; Maatz, Henrike; Blachut, Susanne; Sandmann, Clara-Louisa; Kanda, Masatoshi; Worth, Catherine L; Schafer, Sebastian; Calviello, Lorenzo; Merriott, Rhys; Patone, Giannino; Hummel, Oliver; Wyler, Emanuel; Obermayer, Benedikt; Mücke, Michael B; Lindberg, Eric L; Trnka, Franziska; Memczak, Sebastian; Schilling, Marcel; Felkin, Leanne E; Barton, Paul J R; Quaife, Nicholas M; Vanezis, Konstantinos; Diecke, Sebastian; Mukai, Masaya; Mah, Nancy; Oh, Su-Jun; Kurtz, Andreas; Schramm, Christoph; Schwinge, Dorothee; Sebode, Marcial; Harakalova, Magdalena; Asselbergs, Folkert W; Vink, Aryan; de Weger, Roel A; Viswanathan, Sivakumar; Widjaja, Anissa A; Gärtner-Rommel, Anna; Milting, Hendrik; Dos Remedios, Cris; Knosalla, Christoph; Mertins, Philipp; Landthaler, Markus; Vingron, Martin; Linke, Wolfgang A; Seidman, Jonathan G; Seidman, Christine E; Rajewsky, Nikolaus; Ohler, Uwe; Cook, Stuart A; Hubner, Norbert.
in: CELL, Jahrgang 178, Nr. 1, 27.06.2019, S. 242-260.e29.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The Translational Landscape of the Human Heart
AU - van Heesch, Sebastiaan
AU - Witte, Franziska
AU - Schneider-Lunitz, Valentin
AU - Schulz, Jana F
AU - Adami, Eleonora
AU - Faber, Allison B
AU - Kirchner, Marieluise
AU - Maatz, Henrike
AU - Blachut, Susanne
AU - Sandmann, Clara-Louisa
AU - Kanda, Masatoshi
AU - Worth, Catherine L
AU - Schafer, Sebastian
AU - Calviello, Lorenzo
AU - Merriott, Rhys
AU - Patone, Giannino
AU - Hummel, Oliver
AU - Wyler, Emanuel
AU - Obermayer, Benedikt
AU - Mücke, Michael B
AU - Lindberg, Eric L
AU - Trnka, Franziska
AU - Memczak, Sebastian
AU - Schilling, Marcel
AU - Felkin, Leanne E
AU - Barton, Paul J R
AU - Quaife, Nicholas M
AU - Vanezis, Konstantinos
AU - Diecke, Sebastian
AU - Mukai, Masaya
AU - Mah, Nancy
AU - Oh, Su-Jun
AU - Kurtz, Andreas
AU - Schramm, Christoph
AU - Schwinge, Dorothee
AU - Sebode, Marcial
AU - Harakalova, Magdalena
AU - Asselbergs, Folkert W
AU - Vink, Aryan
AU - de Weger, Roel A
AU - Viswanathan, Sivakumar
AU - Widjaja, Anissa A
AU - Gärtner-Rommel, Anna
AU - Milting, Hendrik
AU - Dos Remedios, Cris
AU - Knosalla, Christoph
AU - Mertins, Philipp
AU - Landthaler, Markus
AU - Vingron, Martin
AU - Linke, Wolfgang A
AU - Seidman, Jonathan G
AU - Seidman, Christine E
AU - Rajewsky, Nikolaus
AU - Ohler, Uwe
AU - Cook, Stuart A
AU - Hubner, Norbert
N1 - Copyright © 2019 Elsevier Inc. All rights reserved.
PY - 2019/6/27
Y1 - 2019/6/27
N2 - Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. We show extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner. Translation downstream of predicted disease-causing protein-truncating variants appears to be frequent, suggesting inefficient translation termination. We identify hundreds of previously undetected microproteins, expressed from lncRNAs and circRNAs, for which we validate the protein products in vivo. The translation of microproteins is not restricted to the heart and prominent in the translatomes of human kidney and liver. We associate these microproteins with diverse cellular processes and compartments and find that many locate to the mitochondria. Importantly, dozens of microproteins are translated from lncRNAs with well-characterized noncoding functions, indicating previously unrecognized biology.
AB - Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human hearts to identify new translation events and quantify the effect of translational regulation. We show extensive translational control of cardiac gene expression, which is orchestrated in a process-specific manner. Translation downstream of predicted disease-causing protein-truncating variants appears to be frequent, suggesting inefficient translation termination. We identify hundreds of previously undetected microproteins, expressed from lncRNAs and circRNAs, for which we validate the protein products in vivo. The translation of microproteins is not restricted to the heart and prominent in the translatomes of human kidney and liver. We associate these microproteins with diverse cellular processes and compartments and find that many locate to the mitochondria. Importantly, dozens of microproteins are translated from lncRNAs with well-characterized noncoding functions, indicating previously unrecognized biology.
KW - Journal Article
U2 - 10.1016/j.cell.2019.05.010
DO - 10.1016/j.cell.2019.05.010
M3 - SCORING: Journal article
C2 - 31155234
VL - 178
SP - 242-260.e29
JO - CELL
JF - CELL
SN - 0092-8674
IS - 1
ER -