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The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells

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The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells. / Hess, Leonard U; Martrus, Glòria; Ziegler, Annerose E; Langeneckert, Annika E; Salzberger, Wilhelm; Goebels, Hanna; Sagebiel, Adrian F; Hagen, Sven H; Poch, Tobias; Ravichandran, Gevitha; Koch, Martina; Schramm, Christoph; Oldhafer, Karl J; Fischer, Lutz; Tiegs, Gisa; Richert, Laura; Bunders, Madeleine J; Lunemann, Sebastian; Altfeld, Marcus.

In: HEPATOL COMMUN, Vol. 4, No. 3, 03.2020, p. 409-424.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hess, LU, Martrus, G, Ziegler, AE, Langeneckert, AE, Salzberger, W, Goebels, H, Sagebiel, AF, Hagen, SH, Poch, T, Ravichandran, G, Koch, M, Schramm, C, Oldhafer, KJ, Fischer, L, Tiegs, G, Richert, L, Bunders, MJ, Lunemann, S & Altfeld, M 2020, 'The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells', HEPATOL COMMUN, vol. 4, no. 3, pp. 409-424. https://doi.org/10.1002/hep4.1463

APA

Hess, L. U., Martrus, G., Ziegler, A. E., Langeneckert, A. E., Salzberger, W., Goebels, H., Sagebiel, A. F., Hagen, S. H., Poch, T., Ravichandran, G., Koch, M., Schramm, C., Oldhafer, K. J., Fischer, L., Tiegs, G., Richert, L., Bunders, M. J., Lunemann, S., & Altfeld, M. (2020). The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells. HEPATOL COMMUN, 4(3), 409-424. https://doi.org/10.1002/hep4.1463

Vancouver

Hess LU, Martrus G, Ziegler AE, Langeneckert AE, Salzberger W, Goebels H et al. The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells. HEPATOL COMMUN. 2020 Mar;4(3):409-424. https://doi.org/10.1002/hep4.1463

Bibtex

@article{9658ebe4b2a2412fac70e2d572d2e559,
title = "The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells",
abstract = "The transcription factor promyelocytic leukemia zinc finger protein (PLZF) is involved in the development of natural killer (NK) cells and innate lymphoid cells, including liver-resident NK cells in mice. In human NK cells, the role of PLZF in liver residency is still unknown. Expression of PLZF in matched human peripheral blood- and liver-derived NK cells and the association of PLZF expression with surface molecules and transcription factors relevant for tissue residency were investigated using multiparameter flow cytometry and assessing single-cell messenger RNA (mRNA) levels. Intrahepatic cluster of differentiation (CD)56bright NK cells expressed significantly higher levels of PLZF than peripheral blood CD56bright NK cells, which were predominantly PLZFlo. Expression of PLZF was highest within C-X-C motif chemokine receptor 6 (CXCR6)+CD69+ liver-resident NK cells among intrahepatic CD56bright NK cell populations. Association of PLZF with liver-residency markers was also reflected at mRNA levels. A small PLZFhiCD56bright NK cell population was identified in peripheral blood that also expressed the liver-residency markers CXCR6 and CD69 and shared functional characteristics with liver-resident NK cells. Conclusion: PLZF is implicated as part of a transcriptional network that promotes liver residency of human NK cells. Expression of liver-homing markers on peripheral blood PLZFhiCD56bright NK cells identifies an intermediate population potentially contributing to the maintenance of liver-resident NK cells.",
author = "Hess, {Leonard U} and Gl{\`o}ria Martrus and Ziegler, {Annerose E} and Langeneckert, {Annika E} and Wilhelm Salzberger and Hanna Goebels and Sagebiel, {Adrian F} and Hagen, {Sven H} and Tobias Poch and Gevitha Ravichandran and Martina Koch and Christoph Schramm and Oldhafer, {Karl J} and Lutz Fischer and Gisa Tiegs and Laura Richert and Bunders, {Madeleine J} and Sebastian Lunemann and Marcus Altfeld",
note = "{\textcopyright} 2020 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.",
year = "2020",
month = mar,
doi = "10.1002/hep4.1463",
language = "English",
volume = "4",
pages = "409--424",
journal = "HEPATOL COMMUN",
issn = "2471-254X",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells

AU - Hess, Leonard U

AU - Martrus, Glòria

AU - Ziegler, Annerose E

AU - Langeneckert, Annika E

AU - Salzberger, Wilhelm

AU - Goebels, Hanna

AU - Sagebiel, Adrian F

AU - Hagen, Sven H

AU - Poch, Tobias

AU - Ravichandran, Gevitha

AU - Koch, Martina

AU - Schramm, Christoph

AU - Oldhafer, Karl J

AU - Fischer, Lutz

AU - Tiegs, Gisa

AU - Richert, Laura

AU - Bunders, Madeleine J

AU - Lunemann, Sebastian

AU - Altfeld, Marcus

N1 - © 2020 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.

PY - 2020/3

Y1 - 2020/3

N2 - The transcription factor promyelocytic leukemia zinc finger protein (PLZF) is involved in the development of natural killer (NK) cells and innate lymphoid cells, including liver-resident NK cells in mice. In human NK cells, the role of PLZF in liver residency is still unknown. Expression of PLZF in matched human peripheral blood- and liver-derived NK cells and the association of PLZF expression with surface molecules and transcription factors relevant for tissue residency were investigated using multiparameter flow cytometry and assessing single-cell messenger RNA (mRNA) levels. Intrahepatic cluster of differentiation (CD)56bright NK cells expressed significantly higher levels of PLZF than peripheral blood CD56bright NK cells, which were predominantly PLZFlo. Expression of PLZF was highest within C-X-C motif chemokine receptor 6 (CXCR6)+CD69+ liver-resident NK cells among intrahepatic CD56bright NK cell populations. Association of PLZF with liver-residency markers was also reflected at mRNA levels. A small PLZFhiCD56bright NK cell population was identified in peripheral blood that also expressed the liver-residency markers CXCR6 and CD69 and shared functional characteristics with liver-resident NK cells. Conclusion: PLZF is implicated as part of a transcriptional network that promotes liver residency of human NK cells. Expression of liver-homing markers on peripheral blood PLZFhiCD56bright NK cells identifies an intermediate population potentially contributing to the maintenance of liver-resident NK cells.

AB - The transcription factor promyelocytic leukemia zinc finger protein (PLZF) is involved in the development of natural killer (NK) cells and innate lymphoid cells, including liver-resident NK cells in mice. In human NK cells, the role of PLZF in liver residency is still unknown. Expression of PLZF in matched human peripheral blood- and liver-derived NK cells and the association of PLZF expression with surface molecules and transcription factors relevant for tissue residency were investigated using multiparameter flow cytometry and assessing single-cell messenger RNA (mRNA) levels. Intrahepatic cluster of differentiation (CD)56bright NK cells expressed significantly higher levels of PLZF than peripheral blood CD56bright NK cells, which were predominantly PLZFlo. Expression of PLZF was highest within C-X-C motif chemokine receptor 6 (CXCR6)+CD69+ liver-resident NK cells among intrahepatic CD56bright NK cell populations. Association of PLZF with liver-residency markers was also reflected at mRNA levels. A small PLZFhiCD56bright NK cell population was identified in peripheral blood that also expressed the liver-residency markers CXCR6 and CD69 and shared functional characteristics with liver-resident NK cells. Conclusion: PLZF is implicated as part of a transcriptional network that promotes liver residency of human NK cells. Expression of liver-homing markers on peripheral blood PLZFhiCD56bright NK cells identifies an intermediate population potentially contributing to the maintenance of liver-resident NK cells.

U2 - 10.1002/hep4.1463

DO - 10.1002/hep4.1463

M3 - SCORING: Journal article

C2 - 32140657

VL - 4

SP - 409

EP - 424

JO - HEPATOL COMMUN

JF - HEPATOL COMMUN

SN - 2471-254X

IS - 3

ER -