The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells
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The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells. / Hess, Leonard U; Martrus, Glòria; Ziegler, Annerose E; Langeneckert, Annika E; Salzberger, Wilhelm; Goebels, Hanna; Sagebiel, Adrian F; Hagen, Sven H; Poch, Tobias; Ravichandran, Gevitha; Koch, Martina; Schramm, Christoph; Oldhafer, Karl J; Fischer, Lutz; Tiegs, Gisa; Richert, Laura; Bunders, Madeleine J; Lunemann, Sebastian; Altfeld, Marcus.
in: HEPATOL COMMUN, Jahrgang 4, Nr. 3, 03.2020, S. 409-424.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells
AU - Hess, Leonard U
AU - Martrus, Glòria
AU - Ziegler, Annerose E
AU - Langeneckert, Annika E
AU - Salzberger, Wilhelm
AU - Goebels, Hanna
AU - Sagebiel, Adrian F
AU - Hagen, Sven H
AU - Poch, Tobias
AU - Ravichandran, Gevitha
AU - Koch, Martina
AU - Schramm, Christoph
AU - Oldhafer, Karl J
AU - Fischer, Lutz
AU - Tiegs, Gisa
AU - Richert, Laura
AU - Bunders, Madeleine J
AU - Lunemann, Sebastian
AU - Altfeld, Marcus
N1 - © 2020 The Authors. Hepatology Communications published by Wiley Periodicals, Inc., on behalf of the American Association for the Study of Liver Diseases.
PY - 2020/3
Y1 - 2020/3
N2 - The transcription factor promyelocytic leukemia zinc finger protein (PLZF) is involved in the development of natural killer (NK) cells and innate lymphoid cells, including liver-resident NK cells in mice. In human NK cells, the role of PLZF in liver residency is still unknown. Expression of PLZF in matched human peripheral blood- and liver-derived NK cells and the association of PLZF expression with surface molecules and transcription factors relevant for tissue residency were investigated using multiparameter flow cytometry and assessing single-cell messenger RNA (mRNA) levels. Intrahepatic cluster of differentiation (CD)56bright NK cells expressed significantly higher levels of PLZF than peripheral blood CD56bright NK cells, which were predominantly PLZFlo. Expression of PLZF was highest within C-X-C motif chemokine receptor 6 (CXCR6)+CD69+ liver-resident NK cells among intrahepatic CD56bright NK cell populations. Association of PLZF with liver-residency markers was also reflected at mRNA levels. A small PLZFhiCD56bright NK cell population was identified in peripheral blood that also expressed the liver-residency markers CXCR6 and CD69 and shared functional characteristics with liver-resident NK cells. Conclusion: PLZF is implicated as part of a transcriptional network that promotes liver residency of human NK cells. Expression of liver-homing markers on peripheral blood PLZFhiCD56bright NK cells identifies an intermediate population potentially contributing to the maintenance of liver-resident NK cells.
AB - The transcription factor promyelocytic leukemia zinc finger protein (PLZF) is involved in the development of natural killer (NK) cells and innate lymphoid cells, including liver-resident NK cells in mice. In human NK cells, the role of PLZF in liver residency is still unknown. Expression of PLZF in matched human peripheral blood- and liver-derived NK cells and the association of PLZF expression with surface molecules and transcription factors relevant for tissue residency were investigated using multiparameter flow cytometry and assessing single-cell messenger RNA (mRNA) levels. Intrahepatic cluster of differentiation (CD)56bright NK cells expressed significantly higher levels of PLZF than peripheral blood CD56bright NK cells, which were predominantly PLZFlo. Expression of PLZF was highest within C-X-C motif chemokine receptor 6 (CXCR6)+CD69+ liver-resident NK cells among intrahepatic CD56bright NK cell populations. Association of PLZF with liver-residency markers was also reflected at mRNA levels. A small PLZFhiCD56bright NK cell population was identified in peripheral blood that also expressed the liver-residency markers CXCR6 and CD69 and shared functional characteristics with liver-resident NK cells. Conclusion: PLZF is implicated as part of a transcriptional network that promotes liver residency of human NK cells. Expression of liver-homing markers on peripheral blood PLZFhiCD56bright NK cells identifies an intermediate population potentially contributing to the maintenance of liver-resident NK cells.
U2 - 10.1002/hep4.1463
DO - 10.1002/hep4.1463
M3 - SCORING: Journal article
C2 - 32140657
VL - 4
SP - 409
EP - 424
JO - HEPATOL COMMUN
JF - HEPATOL COMMUN
SN - 2471-254X
IS - 3
ER -