The structure of the efflux pump AcrB in complex with bile acid
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The structure of the efflux pump AcrB in complex with bile acid. / Drew, David; Klepsch, Mirjam M; Newstead, Simon; Flaig, Ralf; De Gier, Jan-Willem; Iwata, So; Beis, Konstantinos.
In: MOL MEMBR BIOL, Vol. 25, No. 8, 12.2008, p. 677-82.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The structure of the efflux pump AcrB in complex with bile acid
AU - Drew, David
AU - Klepsch, Mirjam M
AU - Newstead, Simon
AU - Flaig, Ralf
AU - De Gier, Jan-Willem
AU - Iwata, So
AU - Beis, Konstantinos
PY - 2008/12
Y1 - 2008/12
N2 - Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.
AB - Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.
KW - Crystallography, X-Ray
KW - Deoxycholic Acid
KW - Escherichia coli
KW - Escherichia coli Proteins
KW - Multidrug Resistance-Associated Proteins
KW - Mutant Proteins
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1080/09687680802552257
DO - 10.1080/09687680802552257
M3 - SCORING: Journal article
C2 - 19023693
VL - 25
SP - 677
EP - 682
IS - 8
ER -