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The structure of the efflux pump AcrB in complex with bile acid

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The structure of the efflux pump AcrB in complex with bile acid. / Drew, David; Klepsch, Mirjam M; Newstead, Simon; Flaig, Ralf; De Gier, Jan-Willem; Iwata, So; Beis, Konstantinos.

in: MOL MEMBR BIOL, Jahrgang 25, Nr. 8, 12.2008, S. 677-82.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Drew, D, Klepsch, MM, Newstead, S, Flaig, R, De Gier, J-W, Iwata, S & Beis, K 2008, 'The structure of the efflux pump AcrB in complex with bile acid', MOL MEMBR BIOL, Jg. 25, Nr. 8, S. 677-82. https://doi.org/10.1080/09687680802552257

APA

Drew, D., Klepsch, M. M., Newstead, S., Flaig, R., De Gier, J-W., Iwata, S., & Beis, K. (2008). The structure of the efflux pump AcrB in complex with bile acid. MOL MEMBR BIOL, 25(8), 677-82. https://doi.org/10.1080/09687680802552257

Vancouver

Drew D, Klepsch MM, Newstead S, Flaig R, De Gier J-W, Iwata S et al. The structure of the efflux pump AcrB in complex with bile acid. MOL MEMBR BIOL. 2008 Dez;25(8):677-82. https://doi.org/10.1080/09687680802552257

Bibtex

@article{9e1054e74f8b4ed3ad6340adc83f2ba1,
title = "The structure of the efflux pump AcrB in complex with bile acid",
abstract = "Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.",
keywords = "Crystallography, X-Ray, Deoxycholic Acid, Escherichia coli, Escherichia coli Proteins, Multidrug Resistance-Associated Proteins, Mutant Proteins, Journal Article, Research Support, Non-U.S. Gov't",
author = "David Drew and Klepsch, {Mirjam M} and Simon Newstead and Ralf Flaig and {De Gier}, Jan-Willem and So Iwata and Konstantinos Beis",
year = "2008",
month = dec,
doi = "10.1080/09687680802552257",
language = "English",
volume = "25",
pages = "677--82",
number = "8",

}

RIS

TY - JOUR

T1 - The structure of the efflux pump AcrB in complex with bile acid

AU - Drew, David

AU - Klepsch, Mirjam M

AU - Newstead, Simon

AU - Flaig, Ralf

AU - De Gier, Jan-Willem

AU - Iwata, So

AU - Beis, Konstantinos

PY - 2008/12

Y1 - 2008/12

N2 - Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.

AB - Gastrointestinal bacteria, like Escherichia coli, must remove bile acid to survive in the gut. Bile acid removal in E. coli is thought to be mediated primarily by the multidrug efflux pump, AcrB. Here, we present the structure of E. coli AcrB in complex with deoxycholate at 3.85 A resolution. All evidence suggests that bile acid is transported out of the cell via the periplasmic vestibule of the AcrAB-TolC complex.

KW - Crystallography, X-Ray

KW - Deoxycholic Acid

KW - Escherichia coli

KW - Escherichia coli Proteins

KW - Multidrug Resistance-Associated Proteins

KW - Mutant Proteins

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1080/09687680802552257

DO - 10.1080/09687680802552257

M3 - SCORING: Journal article

C2 - 19023693

VL - 25

SP - 677

EP - 682

IS - 8

ER -