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The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling

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The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling. / Geissen, M; Heller, S; Pennica, D; Ernsberger, U; Rohrer, H.

In: DEVELOPMENT, Vol. 125, No. 23, 12.1998, p. 4791-801.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Geissen, M, Heller, S, Pennica, D, Ernsberger, U & Rohrer, H 1998, 'The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling', DEVELOPMENT, vol. 125, no. 23, pp. 4791-801.

APA

Geissen, M., Heller, S., Pennica, D., Ernsberger, U., & Rohrer, H. (1998). The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling. DEVELOPMENT, 125(23), 4791-801.

Vancouver

Geissen M, Heller S, Pennica D, Ernsberger U, Rohrer H. The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling. DEVELOPMENT. 1998 Dec;125(23):4791-801.

Bibtex

@article{afdd4ac6c2144dbda0f20f77e9405ab5,
title = "The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling",
abstract = "Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. The differentiation of cholinergic sympathetic neurons is characterized by the expression of choline acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP), induced in vitro by a subfamily of cytokines, including LIF, CNTF, GPA, OSM and cardiotrophin-1 (CT-1). To interfere with the function of these neuropoietic cytokines in vivo, antisense RNA for gp130, the common signal-transducing receptor subunit for neuropoietic cytokines, was expressed in chick sympathetic neurons, using retroviral vectors. A strong reduction in the number of VIP-expressing cells, but not of cells expressing ChAT or the adrenergic marker tyrosine hydroxylase (TH), was observed. These results reveal a physiological role of neuropoietic cytokines for the control of VIP expression during the development of cholinergic sympathetic neurons.",
keywords = "Amino Acid Sequence, Animals, Antigens, CD/chemistry, Cells, Cultured, Chick Embryo, Choline O-Acetyltransferase/genetics, Cytokine Receptor gp130, Cytokines/physiology, Ganglia, Sympathetic/cytology, Gene Expression Regulation, Gene Expression Regulation, Developmental, Humans, Membrane Glycoproteins/chemistry, Molecular Sequence Data, Neurons/classification, Phenotype, RNA, Antisense, Receptors, Cytokine/physiology, Recombinant Proteins/biosynthesis, Retroviridae, Sequence Alignment, Sequence Homology, Amino Acid, Signal Transduction, Transfection, Tyrosine 3-Monooxygenase/genetics, Vasoactive Intestinal Peptide/genetics",
author = "M Geissen and S Heller and D Pennica and U Ernsberger and H Rohrer",
year = "1998",
month = dec,
language = "English",
volume = "125",
pages = "4791--801",
journal = "DEVELOPMENT",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "23",

}

RIS

TY - JOUR

T1 - The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling

AU - Geissen, M

AU - Heller, S

AU - Pennica, D

AU - Ernsberger, U

AU - Rohrer, H

PY - 1998/12

Y1 - 1998/12

N2 - Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. The differentiation of cholinergic sympathetic neurons is characterized by the expression of choline acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP), induced in vitro by a subfamily of cytokines, including LIF, CNTF, GPA, OSM and cardiotrophin-1 (CT-1). To interfere with the function of these neuropoietic cytokines in vivo, antisense RNA for gp130, the common signal-transducing receptor subunit for neuropoietic cytokines, was expressed in chick sympathetic neurons, using retroviral vectors. A strong reduction in the number of VIP-expressing cells, but not of cells expressing ChAT or the adrenergic marker tyrosine hydroxylase (TH), was observed. These results reveal a physiological role of neuropoietic cytokines for the control of VIP expression during the development of cholinergic sympathetic neurons.

AB - Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. The differentiation of cholinergic sympathetic neurons is characterized by the expression of choline acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP), induced in vitro by a subfamily of cytokines, including LIF, CNTF, GPA, OSM and cardiotrophin-1 (CT-1). To interfere with the function of these neuropoietic cytokines in vivo, antisense RNA for gp130, the common signal-transducing receptor subunit for neuropoietic cytokines, was expressed in chick sympathetic neurons, using retroviral vectors. A strong reduction in the number of VIP-expressing cells, but not of cells expressing ChAT or the adrenergic marker tyrosine hydroxylase (TH), was observed. These results reveal a physiological role of neuropoietic cytokines for the control of VIP expression during the development of cholinergic sympathetic neurons.

KW - Amino Acid Sequence

KW - Animals

KW - Antigens, CD/chemistry

KW - Cells, Cultured

KW - Chick Embryo

KW - Choline O-Acetyltransferase/genetics

KW - Cytokine Receptor gp130

KW - Cytokines/physiology

KW - Ganglia, Sympathetic/cytology

KW - Gene Expression Regulation

KW - Gene Expression Regulation, Developmental

KW - Humans

KW - Membrane Glycoproteins/chemistry

KW - Molecular Sequence Data

KW - Neurons/classification

KW - Phenotype

KW - RNA, Antisense

KW - Receptors, Cytokine/physiology

KW - Recombinant Proteins/biosynthesis

KW - Retroviridae

KW - Sequence Alignment

KW - Sequence Homology, Amino Acid

KW - Signal Transduction

KW - Transfection

KW - Tyrosine 3-Monooxygenase/genetics

KW - Vasoactive Intestinal Peptide/genetics

M3 - SCORING: Journal article

C2 - 9806927

VL - 125

SP - 4791

EP - 4801

JO - DEVELOPMENT

JF - DEVELOPMENT

SN - 0950-1991

IS - 23

ER -