Research ExplorerPublicationsThe shape of the radiation dose response for DNA double-stra...

The shape of the radiation dose response for DNA double-strand break induction and repair

Standard

The shape of the radiation dose response for DNA double-strand break induction and repair. / Barnard, Stephen; Bouffler, Simon; Rothkamm, Kai.

In: Genome integrity, Vol. 4, No. 1, 22.03.2013, p. 1.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Barnard, S, Bouffler, S & Rothkamm, K 2013, 'The shape of the radiation dose response for DNA double-strand break induction and repair', Genome integrity, vol. 4, no. 1, pp. 1. https://doi.org/10.1186/2041-9414-4-1

APA

Barnard, S., Bouffler, S., & Rothkamm, K. (2013). The shape of the radiation dose response for DNA double-strand break induction and repair. Genome integrity, 4(1), 1. https://doi.org/10.1186/2041-9414-4-1

Vancouver

Barnard S, Bouffler S, Rothkamm K. The shape of the radiation dose response for DNA double-strand break induction and repair. Genome integrity. 2013 Mar 22;4(1):1. https://doi.org/10.1186/2041-9414-4-1

Bibtex

@article{75709098b1894ab29f3cdeffb9d47ad8,
title = "The shape of the radiation dose response for DNA double-strand break induction and repair",
abstract = "DNA double-strand breaks are among the most deleterious lesions induced by ionising radiation. A range of inter-connected cellular response mechanisms has evolved to enable their efficient repair and thus protect the cell from the harmful consequences of un- or mis-repaired breaks which may include early effects such as cell killing and associated acute toxicities and late effects such as cancer. A number of studies suggest that the induction and repair of double-strand breaks may not always occur linearly with ionising radiation dose. Here we have aimed to identify and discuss some of the biological and methodological factors that can potentially modify the shape of the dose response curve obtained for these endpoints using the most common assays for double-strand breaks, pulsed-field gel electrophoresis and microscopic scoring of radiation-induced foci.",
author = "Stephen Barnard and Simon Bouffler and Kai Rothkamm",
year = "2013",
month = mar,
day = "22",
doi = "10.1186/2041-9414-4-1",
language = "English",
volume = "4",
pages = "1",
journal = "Genome integrity",
issn = "2041-9414",
publisher = "Wolters Kluwer Medknow Publications",
number = "1",

}

RIS

TY - JOUR

T1 - The shape of the radiation dose response for DNA double-strand break induction and repair

AU - Barnard, Stephen

AU - Bouffler, Simon

AU - Rothkamm, Kai

PY - 2013/3/22

Y1 - 2013/3/22

N2 - DNA double-strand breaks are among the most deleterious lesions induced by ionising radiation. A range of inter-connected cellular response mechanisms has evolved to enable their efficient repair and thus protect the cell from the harmful consequences of un- or mis-repaired breaks which may include early effects such as cell killing and associated acute toxicities and late effects such as cancer. A number of studies suggest that the induction and repair of double-strand breaks may not always occur linearly with ionising radiation dose. Here we have aimed to identify and discuss some of the biological and methodological factors that can potentially modify the shape of the dose response curve obtained for these endpoints using the most common assays for double-strand breaks, pulsed-field gel electrophoresis and microscopic scoring of radiation-induced foci.

AB - DNA double-strand breaks are among the most deleterious lesions induced by ionising radiation. A range of inter-connected cellular response mechanisms has evolved to enable their efficient repair and thus protect the cell from the harmful consequences of un- or mis-repaired breaks which may include early effects such as cell killing and associated acute toxicities and late effects such as cancer. A number of studies suggest that the induction and repair of double-strand breaks may not always occur linearly with ionising radiation dose. Here we have aimed to identify and discuss some of the biological and methodological factors that can potentially modify the shape of the dose response curve obtained for these endpoints using the most common assays for double-strand breaks, pulsed-field gel electrophoresis and microscopic scoring of radiation-induced foci.

U2 - 10.1186/2041-9414-4-1

DO - 10.1186/2041-9414-4-1

M3 - SCORING: Journal article

C2 - 23522792

VL - 4

SP - 1

JO - Genome integrity

JF - Genome integrity

SN - 2041-9414

IS - 1

ER -