The role of L-arginine metabolism in neurocritical care patients
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The role of L-arginine metabolism in neurocritical care patients. / Mader, Marius; Czorlich, Patrick.
In: NEURAL REGEN RES, Vol. 17, No. 7, 07.2022, p. 1446-1453.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - The role of L-arginine metabolism in neurocritical care patients
AU - Mader, Marius
AU - Czorlich, Patrick
PY - 2022/7
Y1 - 2022/7
N2 - Nitric oxide is an important mediator of vascular autoregulation and is involved in pathophysiological changes after acute neurological disorders. Nitric oxide is generated by nitric oxide synthases from the amino acid L-arginine. L-arginine can also serve as a substrate for arginases or lead to the generation of dimethylarginines, asymmetric dimethylarginine, and symmetric dimethylarginine, by methylation. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase and can lead to endothelial dysfunction. This review discusses the role of L-arginine metabolism in patients suffering from acute and critical neurological disorders often requiring neuro-intensive care treatment. Conditions addressed in this review include intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and traumatic brain injury. Recent therapeutic advances in the field are described including current randomized controlled trials for traumatic brain injuries and hemorrhagic stroke.
AB - Nitric oxide is an important mediator of vascular autoregulation and is involved in pathophysiological changes after acute neurological disorders. Nitric oxide is generated by nitric oxide synthases from the amino acid L-arginine. L-arginine can also serve as a substrate for arginases or lead to the generation of dimethylarginines, asymmetric dimethylarginine, and symmetric dimethylarginine, by methylation. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase and can lead to endothelial dysfunction. This review discusses the role of L-arginine metabolism in patients suffering from acute and critical neurological disorders often requiring neuro-intensive care treatment. Conditions addressed in this review include intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and traumatic brain injury. Recent therapeutic advances in the field are described including current randomized controlled trials for traumatic brain injuries and hemorrhagic stroke.
U2 - 10.4103/1673-5374.327331
DO - 10.4103/1673-5374.327331
M3 - SCORING: Review article
VL - 17
SP - 1446
EP - 1453
JO - NEURAL REGEN RES
JF - NEURAL REGEN RES
SN - 1673-5374
IS - 7
ER -