PortalPublikationenThe role of L-arginine metabolism in neurocritical care pati...

The role of L-arginine metabolism in neurocritical care patients

Standard

The role of L-arginine metabolism in neurocritical care patients. / Mader, Marius; Czorlich, Patrick.

in: NEURAL REGEN RES, Jahrgang 17, Nr. 7, 07.2022, S. 1446-1453.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Mader, M & Czorlich, P 2022, 'The role of L-arginine metabolism in neurocritical care patients', NEURAL REGEN RES, Jg. 17, Nr. 7, S. 1446-1453. https://doi.org/10.4103/1673-5374.327331

APA

Mader, M., & Czorlich, P. (2022). The role of L-arginine metabolism in neurocritical care patients. NEURAL REGEN RES, 17(7), 1446-1453. https://doi.org/10.4103/1673-5374.327331

Vancouver

Mader M, Czorlich P. The role of L-arginine metabolism in neurocritical care patients. NEURAL REGEN RES. 2022 Jul;17(7):1446-1453. https://doi.org/10.4103/1673-5374.327331

Bibtex

@article{b7bf904b1c2a488d8f0511a90029d563,
title = "The role of L-arginine metabolism in neurocritical care patients",
abstract = "Nitric oxide is an important mediator of vascular autoregulation and is involved in pathophysiological changes after acute neurological disorders. Nitric oxide is generated by nitric oxide synthases from the amino acid L-arginine. L-arginine can also serve as a substrate for arginases or lead to the generation of dimethylarginines, asymmetric dimethylarginine, and symmetric dimethylarginine, by methylation. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase and can lead to endothelial dysfunction. This review discusses the role of L-arginine metabolism in patients suffering from acute and critical neurological disorders often requiring neuro-intensive care treatment. Conditions addressed in this review include intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and traumatic brain injury. Recent therapeutic advances in the field are described including current randomized controlled trials for traumatic brain injuries and hemorrhagic stroke.",
author = "Marius Mader and Patrick Czorlich",
year = "2022",
month = jul,
doi = "10.4103/1673-5374.327331",
language = "English",
volume = "17",
pages = "1446--1453",
journal = "NEURAL REGEN RES",
issn = "1673-5374",
publisher = "Editorial Board of Neural Regeneration Research",
number = "7",

}

RIS

TY - JOUR

T1 - The role of L-arginine metabolism in neurocritical care patients

AU - Mader, Marius

AU - Czorlich, Patrick

PY - 2022/7

Y1 - 2022/7

N2 - Nitric oxide is an important mediator of vascular autoregulation and is involved in pathophysiological changes after acute neurological disorders. Nitric oxide is generated by nitric oxide synthases from the amino acid L-arginine. L-arginine can also serve as a substrate for arginases or lead to the generation of dimethylarginines, asymmetric dimethylarginine, and symmetric dimethylarginine, by methylation. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase and can lead to endothelial dysfunction. This review discusses the role of L-arginine metabolism in patients suffering from acute and critical neurological disorders often requiring neuro-intensive care treatment. Conditions addressed in this review include intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and traumatic brain injury. Recent therapeutic advances in the field are described including current randomized controlled trials for traumatic brain injuries and hemorrhagic stroke.

AB - Nitric oxide is an important mediator of vascular autoregulation and is involved in pathophysiological changes after acute neurological disorders. Nitric oxide is generated by nitric oxide synthases from the amino acid L-arginine. L-arginine can also serve as a substrate for arginases or lead to the generation of dimethylarginines, asymmetric dimethylarginine, and symmetric dimethylarginine, by methylation. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase and can lead to endothelial dysfunction. This review discusses the role of L-arginine metabolism in patients suffering from acute and critical neurological disorders often requiring neuro-intensive care treatment. Conditions addressed in this review include intracerebral hemorrhage, aneurysmal subarachnoid hemorrhage, and traumatic brain injury. Recent therapeutic advances in the field are described including current randomized controlled trials for traumatic brain injuries and hemorrhagic stroke.

U2 - 10.4103/1673-5374.327331

DO - 10.4103/1673-5374.327331

M3 - SCORING: Review article

VL - 17

SP - 1446

EP - 1453

JO - NEURAL REGEN RES

JF - NEURAL REGEN RES

SN - 1673-5374

IS - 7

ER -