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The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders

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The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders. / Bayraktar, Gonca; Kreutz, Michael R.

In: FRONT MOL NEUROSCI, Vol. 11, 23.05.2018, p. 169.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Bayraktar, G & Kreutz, MR 2018, 'The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders', FRONT MOL NEUROSCI, vol. 11, pp. 169. https://doi.org/10.3389/fnmol.2018.00169

APA

Bayraktar, G., & Kreutz, M. R. (2018). The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders. FRONT MOL NEUROSCI, 11, 169. https://doi.org/10.3389/fnmol.2018.00169

Vancouver

Bayraktar G, Kreutz MR. The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders. FRONT MOL NEUROSCI. 2018 May 23;11:169. https://doi.org/10.3389/fnmol.2018.00169

Bibtex

@article{003ce134d0e44d9fb901b11918cdfcdf,
title = "The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders",
abstract = "Over the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this mini-review, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.",
keywords = "Journal Article, Review",
author = "Gonca Bayraktar and Kreutz, {Michael R}",
year = "2018",
month = may,
day = "23",
doi = "10.3389/fnmol.2018.00169",
language = "English",
volume = "11",
pages = "169",
journal = "FRONT MOL NEUROSCI",
issn = "1662-5099",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders

AU - Bayraktar, Gonca

AU - Kreutz, Michael R

PY - 2018/5/23

Y1 - 2018/5/23

N2 - Over the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this mini-review, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.

AB - Over the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this mini-review, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.

KW - Journal Article

KW - Review

U2 - 10.3389/fnmol.2018.00169

DO - 10.3389/fnmol.2018.00169

M3 - SCORING: Review article

C2 - 29875631

VL - 11

SP - 169

JO - FRONT MOL NEUROSCI

JF - FRONT MOL NEUROSCI

SN - 1662-5099

ER -