The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders
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The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders. / Bayraktar, Gonca; Kreutz, Michael R.
in: FRONT MOL NEUROSCI, Jahrgang 11, 23.05.2018, S. 169.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders
AU - Bayraktar, Gonca
AU - Kreutz, Michael R
PY - 2018/5/23
Y1 - 2018/5/23
N2 - Over the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this mini-review, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.
AB - Over the last decade, an increasing number of reports underscored the importance of epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and erasers recognize, establish, and remove the epigenetic tags in nucleosomes, respectively. One such regulation concerns DNA-methylation and demethylation, which are highly dynamic and activity-dependent processes even in the adult neurons. It is nowadays widely believed that external stimuli control the methylation marks on the DNA and that such processes serve transcriptional regulation in neurons. In this mini-review, we cover the current knowledge on the regulatory mechanisms controlling in particular DNA demethylation as well as the possible functional consequences in health and disease.
KW - Journal Article
KW - Review
U2 - 10.3389/fnmol.2018.00169
DO - 10.3389/fnmol.2018.00169
M3 - SCORING: Review article
C2 - 29875631
VL - 11
SP - 169
JO - FRONT MOL NEUROSCI
JF - FRONT MOL NEUROSCI
SN - 1662-5099
ER -