The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations
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The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations. / Maurer, Florian P.
In: J CLIN MICROBIOL, Vol. 53, No. 6, 06.2015, p. 1806-11.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations
AU - Maurer, Florian P
N1 - Copyright © 2015, American Society for Microbiology. All Rights Reserved.
PY - 2015/6
Y1 - 2015/6
N2 - This study aimed to determine resistant-population cutoffs (RCOFFs) to allow for improved characterization of antimicrobial susceptibility patterns in bacterial populations. RCOFFs can complement epidemiological cutoff (ECOFF)-based settings of clinical breakpoints (CBPs) by systematically describing the correlation between non-wild-type and wild-type populations. We illustrate this concept by describing three paradigmatic examples of wild-type and non-wild-type Escherichia coli populations from our clinical strain database of disk diffusion diameters. The statistical determination of RCOFFs and ECOFFs and their standardized applications in antimicrobial susceptibility testing (AST) facilitates the assignment of isolates to wild-type or non-wild-type populations. This should improve the correlation of in vitro AST data and distinct antibiotic resistance mechanisms with clinical outcome facilitating the setting and validation of CBPs.
AB - This study aimed to determine resistant-population cutoffs (RCOFFs) to allow for improved characterization of antimicrobial susceptibility patterns in bacterial populations. RCOFFs can complement epidemiological cutoff (ECOFF)-based settings of clinical breakpoints (CBPs) by systematically describing the correlation between non-wild-type and wild-type populations. We illustrate this concept by describing three paradigmatic examples of wild-type and non-wild-type Escherichia coli populations from our clinical strain database of disk diffusion diameters. The statistical determination of RCOFFs and ECOFFs and their standardized applications in antimicrobial susceptibility testing (AST) facilitates the assignment of isolates to wild-type or non-wild-type populations. This should improve the correlation of in vitro AST data and distinct antibiotic resistance mechanisms with clinical outcome facilitating the setting and validation of CBPs.
KW - Anti-Bacterial Agents
KW - Drug Resistance, Bacterial
KW - Escherichia coli
KW - Escherichia coli Infections
KW - Humans
KW - Microbial Sensitivity Tests
KW - Reference Values
KW - Reproducibility of Results
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1128/JCM.03505-14
DO - 10.1128/JCM.03505-14
M3 - SCORING: Journal article
C2 - 25762769
VL - 53
SP - 1806
EP - 1811
JO - J CLIN MICROBIOL
JF - J CLIN MICROBIOL
SN - 0095-1137
IS - 6
ER -