The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations

Florian P Maurer

doi:10.1128/JCM.03505-14

The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations

Standard

The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations. / Maurer, Florian P.

in: J CLIN MICROBIOL, Jahrgang 53, Nr. 6, 06.2015, S. 1806-11.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Maurer, FP 2015, 'The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations', J CLIN MICROBIOL, Jg. 53, Nr. 6, S. 1806-11. https://doi.org/10.1128/JCM.03505-14

APA

Maurer, F. P. (2015). The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations. J CLIN MICROBIOL, 53(6), 1806-11. https://doi.org/10.1128/JCM.03505-14

Vancouver

Maurer FP. The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations. J CLIN MICROBIOL. 2015 Jun;53(6):1806-11. https://doi.org/10.1128/JCM.03505-14

Bibtex

@article{4a1b070ce700422793d72e74ec0eb45c,

title = "The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations",

abstract = "This study aimed to determine resistant-population cutoffs (RCOFFs) to allow for improved characterization of antimicrobial susceptibility patterns in bacterial populations. RCOFFs can complement epidemiological cutoff (ECOFF)-based settings of clinical breakpoints (CBPs) by systematically describing the correlation between non-wild-type and wild-type populations. We illustrate this concept by describing three paradigmatic examples of wild-type and non-wild-type Escherichia coli populations from our clinical strain database of disk diffusion diameters. The statistical determination of RCOFFs and ECOFFs and their standardized applications in antimicrobial susceptibility testing (AST) facilitates the assignment of isolates to wild-type or non-wild-type populations. This should improve the correlation of in vitro AST data and distinct antibiotic resistance mechanisms with clinical outcome facilitating the setting and validation of CBPs.",

keywords = "Anti-Bacterial Agents, Drug Resistance, Bacterial, Escherichia coli, Escherichia coli Infections, Humans, Microbial Sensitivity Tests, Reference Values, Reproducibility of Results, Journal Article, Research Support, Non-U.S. Gov't",

author = "Maurer, {Florian P}",

year = "2015",

month = jun,

doi = "10.1128/JCM.03505-14",

language = "English",

volume = "53",

pages = "1806--11",

journal = "J CLIN MICROBIOL",

issn = "0095-1137",

publisher = "American Society for Microbiology",

number = "6",

}

RIS

TY - JOUR

T1 - The Resistant-Population Cutoff (RCOFF)a New Concept for Improved Characterization of Antimicrobial Susceptibility Patterns of Non-Wild-Type Bacterial Populations

AU - Maurer, Florian P

PY - 2015/6

Y1 - 2015/6

N2 - This study aimed to determine resistant-population cutoffs (RCOFFs) to allow for improved characterization of antimicrobial susceptibility patterns in bacterial populations. RCOFFs can complement epidemiological cutoff (ECOFF)-based settings of clinical breakpoints (CBPs) by systematically describing the correlation between non-wild-type and wild-type populations. We illustrate this concept by describing three paradigmatic examples of wild-type and non-wild-type Escherichia coli populations from our clinical strain database of disk diffusion diameters. The statistical determination of RCOFFs and ECOFFs and their standardized applications in antimicrobial susceptibility testing (AST) facilitates the assignment of isolates to wild-type or non-wild-type populations. This should improve the correlation of in vitro AST data and distinct antibiotic resistance mechanisms with clinical outcome facilitating the setting and validation of CBPs.

AB - This study aimed to determine resistant-population cutoffs (RCOFFs) to allow for improved characterization of antimicrobial susceptibility patterns in bacterial populations. RCOFFs can complement epidemiological cutoff (ECOFF)-based settings of clinical breakpoints (CBPs) by systematically describing the correlation between non-wild-type and wild-type populations. We illustrate this concept by describing three paradigmatic examples of wild-type and non-wild-type Escherichia coli populations from our clinical strain database of disk diffusion diameters. The statistical determination of RCOFFs and ECOFFs and their standardized applications in antimicrobial susceptibility testing (AST) facilitates the assignment of isolates to wild-type or non-wild-type populations. This should improve the correlation of in vitro AST data and distinct antibiotic resistance mechanisms with clinical outcome facilitating the setting and validation of CBPs.

KW - Anti-Bacterial Agents

KW - Drug Resistance, Bacterial

KW - Escherichia coli

KW - Escherichia coli Infections

KW - Humans

KW - Microbial Sensitivity Tests

KW - Reference Values

KW - Reproducibility of Results

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1128/JCM.03505-14

DO - 10.1128/JCM.03505-14

M3 - SCORING: Journal article

C2 - 25762769

VL - 53

SP - 1806

EP - 1811

JO - J CLIN MICROBIOL

JF - J CLIN MICROBIOL

SN - 0095-1137

IS - 6

ER -