The RENEB operational basis: complement of established biodosimetric assays
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The RENEB operational basis: complement of established biodosimetric assays. / Wojcik, Andrzej; Oestreicher, Ursula; Barrios, Lleonard; Vral, Anne; Terzoudi, Georgia; Ainsbury, Elizabeth; Rothkamm, Kai; Trompier, Francois; Kulka, Ulrike.
In: INT J RADIAT BIOL, Vol. 93, No. 1, 01.2017, p. 15-19.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The RENEB operational basis: complement of established biodosimetric assays
AU - Wojcik, Andrzej
AU - Oestreicher, Ursula
AU - Barrios, Lleonard
AU - Vral, Anne
AU - Terzoudi, Georgia
AU - Ainsbury, Elizabeth
AU - Rothkamm, Kai
AU - Trompier, Francois
AU - Kulka, Ulrike
PY - 2017/1
Y1 - 2017/1
N2 - PURPOSE: To set up an operational basis of the Realizing the European Network of Biodosimetry (RENEB) network within which the application of seven established biodosimetric tools (the dicentric assay, the FISH assay, the micronucleus assay, the PCC assay, the gamma-H2AX assay, electron paramagnetic resonance and optically stimulated luminescence) will be compared and standardized among the participating laboratories.METHODOLOGY: Two intercomparisons were organized where blood samples and smartphone components were irradiated, coded and sent out to participating laboratories for dosimetric analysis. Moreover, an accident exercise was organized during which each RENEB partner had the chance to practice the procedure of activating the network and to handle large amounts of dosimetric results.RESULTS: All activities were carried out as planned. Overall, the precision of dose estimates improved between intercomparisons 1 and 2, clearly showing the value of running such regular activities.CONCLUSIONS: The RENEB network is fully operational and ready to act in case of a major radiation emergency. Moreover, the high capacity for analyzing radiation-induced damage in cells and personal electronic devices makes the network suitable for large-scale analyses of low doses effects, where high numbers of samples must be scored in order to detect weak effects.
AB - PURPOSE: To set up an operational basis of the Realizing the European Network of Biodosimetry (RENEB) network within which the application of seven established biodosimetric tools (the dicentric assay, the FISH assay, the micronucleus assay, the PCC assay, the gamma-H2AX assay, electron paramagnetic resonance and optically stimulated luminescence) will be compared and standardized among the participating laboratories.METHODOLOGY: Two intercomparisons were organized where blood samples and smartphone components were irradiated, coded and sent out to participating laboratories for dosimetric analysis. Moreover, an accident exercise was organized during which each RENEB partner had the chance to practice the procedure of activating the network and to handle large amounts of dosimetric results.RESULTS: All activities were carried out as planned. Overall, the precision of dose estimates improved between intercomparisons 1 and 2, clearly showing the value of running such regular activities.CONCLUSIONS: The RENEB network is fully operational and ready to act in case of a major radiation emergency. Moreover, the high capacity for analyzing radiation-induced damage in cells and personal electronic devices makes the network suitable for large-scale analyses of low doses effects, where high numbers of samples must be scored in order to detect weak effects.
U2 - 10.1080/09553002.2016.1235296
DO - 10.1080/09553002.2016.1235296
M3 - SCORING: Journal article
C2 - 27778526
VL - 93
SP - 15
EP - 19
JO - INT J RADIAT BIOL
JF - INT J RADIAT BIOL
SN - 0955-3002
IS - 1
ER -
