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The nucleus acts as a ruler tailoring cell responses to spatial constraints

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The nucleus acts as a ruler tailoring cell responses to spatial constraints. / Lomakin, A J; Cattin, C J; Cuvelier, D; Alraies, Z; Molina, M; Nader, G P F; Srivastava, N; Sáez, P J; Garcia-Arcos, J M; Zhitnyak, I Y; Bhargava, A; Driscoll, M K; Welf, E S; Fiolka, R; Petrie, R J; De Silva, N S; González-Granado, J M; Manel, N; Lennon-Duménil, A M; Müller, D J; Piel, M.

In: SCIENCE, Vol. 370, No. 6514, 16.10.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lomakin, AJ, Cattin, CJ, Cuvelier, D, Alraies, Z, Molina, M, Nader, GPF, Srivastava, N, Sáez, PJ, Garcia-Arcos, JM, Zhitnyak, IY, Bhargava, A, Driscoll, MK, Welf, ES, Fiolka, R, Petrie, RJ, De Silva, NS, González-Granado, JM, Manel, N, Lennon-Duménil, AM, Müller, DJ & Piel, M 2020, 'The nucleus acts as a ruler tailoring cell responses to spatial constraints', SCIENCE, vol. 370, no. 6514. https://doi.org/10.1126/science.aba2894

APA

Lomakin, A. J., Cattin, C. J., Cuvelier, D., Alraies, Z., Molina, M., Nader, G. P. F., Srivastava, N., Sáez, P. J., Garcia-Arcos, J. M., Zhitnyak, I. Y., Bhargava, A., Driscoll, M. K., Welf, E. S., Fiolka, R., Petrie, R. J., De Silva, N. S., González-Granado, J. M., Manel, N., Lennon-Duménil, A. M., ... Piel, M. (2020). The nucleus acts as a ruler tailoring cell responses to spatial constraints. SCIENCE, 370(6514). https://doi.org/10.1126/science.aba2894

Vancouver

Lomakin AJ, Cattin CJ, Cuvelier D, Alraies Z, Molina M, Nader GPF et al. The nucleus acts as a ruler tailoring cell responses to spatial constraints. SCIENCE. 2020 Oct 16;370(6514). https://doi.org/10.1126/science.aba2894

Bibtex

@article{7321e50ec1a442d7afcc561588077128,
title = "The nucleus acts as a ruler tailoring cell responses to spatial constraints",
abstract = "The microscopic environment inside a metazoan organism is highly crowded. Whether individual cells can tailor their behavior to the limited space remains unclear. In this study, we found that cells measure the degree of spatial confinement by using their largest and stiffest organelle, the nucleus. Cell confinement below a resting nucleus size deforms the nucleus, which expands and stretches its envelope. This activates signaling to the actomyosin cortex via nuclear envelope stretch-sensitive proteins, up-regulating cell contractility. We established that the tailored contractile response constitutes a nuclear ruler-based signaling pathway involved in migratory cell behaviors. Cells rely on the nuclear ruler to modulate the motive force that enables their passage through restrictive pores in complex three-dimensional environments, a process relevant to cancer cell invasion, immune responses, and embryonic development.",
keywords = "Actomyosin/metabolism, Animals, Cell Movement, Embryonic Development, HeLa Cells, Humans, Mechanotransduction, Cellular, Mice, Myosin Heavy Chains/metabolism, Neoplasm Invasiveness, Neoplasms/pathology, Nuclear Envelope/physiology",
author = "Lomakin, {A J} and Cattin, {C J} and D Cuvelier and Z Alraies and M Molina and Nader, {G P F} and N Srivastava and S{\'a}ez, {P J} and Garcia-Arcos, {J M} and Zhitnyak, {I Y} and A Bhargava and Driscoll, {M K} and Welf, {E S} and R Fiolka and Petrie, {R J} and {De Silva}, {N S} and Gonz{\'a}lez-Granado, {J M} and N Manel and Lennon-Dum{\'e}nil, {A M} and M{\"u}ller, {D J} and M Piel",
note = "Copyright {\textcopyright} 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",
year = "2020",
month = oct,
day = "16",
doi = "10.1126/science.aba2894",
language = "English",
volume = "370",
journal = "SCIENCE",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6514",

}

RIS

TY - JOUR

T1 - The nucleus acts as a ruler tailoring cell responses to spatial constraints

AU - Lomakin, A J

AU - Cattin, C J

AU - Cuvelier, D

AU - Alraies, Z

AU - Molina, M

AU - Nader, G P F

AU - Srivastava, N

AU - Sáez, P J

AU - Garcia-Arcos, J M

AU - Zhitnyak, I Y

AU - Bhargava, A

AU - Driscoll, M K

AU - Welf, E S

AU - Fiolka, R

AU - Petrie, R J

AU - De Silva, N S

AU - González-Granado, J M

AU - Manel, N

AU - Lennon-Duménil, A M

AU - Müller, D J

AU - Piel, M

N1 - Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

PY - 2020/10/16

Y1 - 2020/10/16

N2 - The microscopic environment inside a metazoan organism is highly crowded. Whether individual cells can tailor their behavior to the limited space remains unclear. In this study, we found that cells measure the degree of spatial confinement by using their largest and stiffest organelle, the nucleus. Cell confinement below a resting nucleus size deforms the nucleus, which expands and stretches its envelope. This activates signaling to the actomyosin cortex via nuclear envelope stretch-sensitive proteins, up-regulating cell contractility. We established that the tailored contractile response constitutes a nuclear ruler-based signaling pathway involved in migratory cell behaviors. Cells rely on the nuclear ruler to modulate the motive force that enables their passage through restrictive pores in complex three-dimensional environments, a process relevant to cancer cell invasion, immune responses, and embryonic development.

AB - The microscopic environment inside a metazoan organism is highly crowded. Whether individual cells can tailor their behavior to the limited space remains unclear. In this study, we found that cells measure the degree of spatial confinement by using their largest and stiffest organelle, the nucleus. Cell confinement below a resting nucleus size deforms the nucleus, which expands and stretches its envelope. This activates signaling to the actomyosin cortex via nuclear envelope stretch-sensitive proteins, up-regulating cell contractility. We established that the tailored contractile response constitutes a nuclear ruler-based signaling pathway involved in migratory cell behaviors. Cells rely on the nuclear ruler to modulate the motive force that enables their passage through restrictive pores in complex three-dimensional environments, a process relevant to cancer cell invasion, immune responses, and embryonic development.

KW - Actomyosin/metabolism

KW - Animals

KW - Cell Movement

KW - Embryonic Development

KW - HeLa Cells

KW - Humans

KW - Mechanotransduction, Cellular

KW - Mice

KW - Myosin Heavy Chains/metabolism

KW - Neoplasm Invasiveness

KW - Neoplasms/pathology

KW - Nuclear Envelope/physiology

U2 - 10.1126/science.aba2894

DO - 10.1126/science.aba2894

M3 - SCORING: Journal article

C2 - 33060332

VL - 370

JO - SCIENCE

JF - SCIENCE

SN - 0036-8075

IS - 6514

ER -