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The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37.

Standard

The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37. / Rezgaoui, Meriem; Süsens, Ute; Ignatov, Atanas; Gelderblom, Mathias; Glassmeier, Günter; Franke, Inga; Urny, Jens; Imai, Yuzuru; Takahashi, Ryosuke; Schaller, H Chica.

In: J CELL SCI, Vol. 119, No. 3, 3, 2006, p. 542-549.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rezgaoui, M, Süsens, U, Ignatov, A, Gelderblom, M, Glassmeier, G, Franke, I, Urny, J, Imai, Y, Takahashi, R & Schaller, HC 2006, 'The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37.', J CELL SCI, vol. 119, no. 3, 3, pp. 542-549. <http://www.ncbi.nlm.nih.gov/pubmed/16443751?dopt=Citation>

APA

Rezgaoui, M., Süsens, U., Ignatov, A., Gelderblom, M., Glassmeier, G., Franke, I., Urny, J., Imai, Y., Takahashi, R., & Schaller, H. C. (2006). The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37. J CELL SCI, 119(3), 542-549. [3]. http://www.ncbi.nlm.nih.gov/pubmed/16443751?dopt=Citation

Vancouver

Rezgaoui M, Süsens U, Ignatov A, Gelderblom M, Glassmeier G, Franke I et al. The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37. J CELL SCI. 2006;119(3):542-549. 3.

Bibtex

@article{8ed52f5790974f68b121b9b28e1683ab,
title = "The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37.",
abstract = "The neuropeptide head activator (HA) is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. HA signalling is mediated by a G-protein-coupled receptor (GPCR). Orphan GPCRs with homology to peptide receptors were screened for HA interaction. Electrophysiological recordings in frog oocytes and in mammalian cell lines as well as Ca(2+) mobilisation assays revealed nanomolar affinities of HA to GPR37. HA signal transduction through GPR37 was mediated by an inhibitory G protein and required Ca(2+) influx through a channel of the transient receptor potential (TRP) family. It also required activation of Ca(2+)-dependent calmodulin kinase and phosphoinositide 3-kinase. Respective inhibitors blocked HA signalling and HA-induced mitosis in GPR37-expressing cells. HA treatment resulted in internalisation of GPR37. Overexpression of GPR37 led to aggregate formation, retention of the receptor in the cytoplasm and low survival rates of transfected cells, confirming the notion that misfolded GPR37 contributes to cell death, as observed in Parkinson's disease.",
author = "Meriem Rezgaoui and Ute S{\"u}sens and Atanas Ignatov and Mathias Gelderblom and G{\"u}nter Glassmeier and Inga Franke and Jens Urny and Yuzuru Imai and Ryosuke Takahashi and Schaller, {H Chica}",
year = "2006",
language = "Deutsch",
volume = "119",
pages = "542--549",
journal = "J CELL SCI",
issn = "0021-9533",
publisher = "Company of Biologists Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - The neuropeptide head activator is a high-affinity ligand for the orphan G-protein-coupled receptor GPR37.

AU - Rezgaoui, Meriem

AU - Süsens, Ute

AU - Ignatov, Atanas

AU - Gelderblom, Mathias

AU - Glassmeier, Günter

AU - Franke, Inga

AU - Urny, Jens

AU - Imai, Yuzuru

AU - Takahashi, Ryosuke

AU - Schaller, H Chica

PY - 2006

Y1 - 2006

N2 - The neuropeptide head activator (HA) is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. HA signalling is mediated by a G-protein-coupled receptor (GPCR). Orphan GPCRs with homology to peptide receptors were screened for HA interaction. Electrophysiological recordings in frog oocytes and in mammalian cell lines as well as Ca(2+) mobilisation assays revealed nanomolar affinities of HA to GPR37. HA signal transduction through GPR37 was mediated by an inhibitory G protein and required Ca(2+) influx through a channel of the transient receptor potential (TRP) family. It also required activation of Ca(2+)-dependent calmodulin kinase and phosphoinositide 3-kinase. Respective inhibitors blocked HA signalling and HA-induced mitosis in GPR37-expressing cells. HA treatment resulted in internalisation of GPR37. Overexpression of GPR37 led to aggregate formation, retention of the receptor in the cytoplasm and low survival rates of transfected cells, confirming the notion that misfolded GPR37 contributes to cell death, as observed in Parkinson's disease.

AB - The neuropeptide head activator (HA) is a mitogen for mammalian cell lines of neuronal or neuroendocrine origin. HA signalling is mediated by a G-protein-coupled receptor (GPCR). Orphan GPCRs with homology to peptide receptors were screened for HA interaction. Electrophysiological recordings in frog oocytes and in mammalian cell lines as well as Ca(2+) mobilisation assays revealed nanomolar affinities of HA to GPR37. HA signal transduction through GPR37 was mediated by an inhibitory G protein and required Ca(2+) influx through a channel of the transient receptor potential (TRP) family. It also required activation of Ca(2+)-dependent calmodulin kinase and phosphoinositide 3-kinase. Respective inhibitors blocked HA signalling and HA-induced mitosis in GPR37-expressing cells. HA treatment resulted in internalisation of GPR37. Overexpression of GPR37 led to aggregate formation, retention of the receptor in the cytoplasm and low survival rates of transfected cells, confirming the notion that misfolded GPR37 contributes to cell death, as observed in Parkinson's disease.

M3 - SCORING: Zeitschriftenaufsatz

VL - 119

SP - 542

EP - 549

JO - J CELL SCI

JF - J CELL SCI

SN - 0021-9533

IS - 3

M1 - 3

ER -