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The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.

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The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. / Rogaeva, Ekaterina; Meng, Yan; Lee, Joseph H; Gu, Yongjun; Kawarai, Toshitaka; Zou, Fanggeng; Katayama, Taiichi; Baldwin, Clinton T; Cheng, Rong; Hasegawa, Hiroshi; Chen, Fusheng; Shibata, Nobuto; Lunetta, Kathryn L; Pardossi-Piquard, Raphaelle; Bohm, Christopher; Wakutani, Yosuke; Cupples, L Adrienne; Cuenco, Karen T; Green, Robert C; Pinessi, Lorenzo; Rainero, Innocenzo; Sorbi, Sandro; Bruni, Amalia; Duara, Ranjan; Friedland, Robert P; Inzelberg, Rivka; Hampe, Wolfgang; Bujo, Hideaki; Song, You-Qiang; Andersen, Olav M; Willnow, Thomas E; Graff-Radford, Neill; Petersen, Ronald C; Dickson, Dennis; Der, Sandy D; Fraser, Paul E; Schmitt-Ulms, Gerold; Younkin, Steven; Mayeux, Richard; Farrer, Lindsay A; Peter, St George-Hyslop.

In: NAT GENET, Vol. 39, No. 2, 2, 2007, p. 168-177.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rogaeva, E, Meng, Y, Lee, JH, Gu, Y, Kawarai, T, Zou, F, Katayama, T, Baldwin, CT, Cheng, R, Hasegawa, H, Chen, F, Shibata, N, Lunetta, KL, Pardossi-Piquard, R, Bohm, C, Wakutani, Y, Cupples, LA, Cuenco, KT, Green, RC, Pinessi, L, Rainero, I, Sorbi, S, Bruni, A, Duara, R, Friedland, RP, Inzelberg, R, Hampe, W, Bujo, H, Song, Y-Q, Andersen, OM, Willnow, TE, Graff-Radford, N, Petersen, RC, Dickson, D, Der, SD, Fraser, PE, Schmitt-Ulms, G, Younkin, S, Mayeux, R, Farrer, LA & Peter, SG-H 2007, 'The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.', NAT GENET, vol. 39, no. 2, 2, pp. 168-177. <http://www.ncbi.nlm.nih.gov/pubmed/17220890?dopt=Citation>

APA

Rogaeva, E., Meng, Y., Lee, J. H., Gu, Y., Kawarai, T., Zou, F., Katayama, T., Baldwin, C. T., Cheng, R., Hasegawa, H., Chen, F., Shibata, N., Lunetta, K. L., Pardossi-Piquard, R., Bohm, C., Wakutani, Y., Cupples, L. A., Cuenco, K. T., Green, R. C., ... Peter, S. G-H. (2007). The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. NAT GENET, 39(2), 168-177. [2]. http://www.ncbi.nlm.nih.gov/pubmed/17220890?dopt=Citation

Vancouver

Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. NAT GENET. 2007;39(2):168-177. 2.

Bibtex

@article{e1f7d0903918426c8398ad84d7aea864,
title = "The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.",
abstract = "The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. We also show that SORL1 directs trafficking of APP into recycling pathways and that when SORL1 is underexpressed, APP is sorted into Abeta-generating compartments. These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.",
author = "Ekaterina Rogaeva and Yan Meng and Lee, {Joseph H} and Yongjun Gu and Toshitaka Kawarai and Fanggeng Zou and Taiichi Katayama and Baldwin, {Clinton T} and Rong Cheng and Hiroshi Hasegawa and Fusheng Chen and Nobuto Shibata and Lunetta, {Kathryn L} and Raphaelle Pardossi-Piquard and Christopher Bohm and Yosuke Wakutani and Cupples, {L Adrienne} and Cuenco, {Karen T} and Green, {Robert C} and Lorenzo Pinessi and Innocenzo Rainero and Sandro Sorbi and Amalia Bruni and Ranjan Duara and Friedland, {Robert P} and Rivka Inzelberg and Wolfgang Hampe and Hideaki Bujo and You-Qiang Song and Andersen, {Olav M} and Willnow, {Thomas E} and Neill Graff-Radford and Petersen, {Ronald C} and Dennis Dickson and Der, {Sandy D} and Fraser, {Paul E} and Gerold Schmitt-Ulms and Steven Younkin and Richard Mayeux and Farrer, {Lindsay A} and Peter, {St George-Hyslop}",
year = "2007",
language = "Deutsch",
volume = "39",
pages = "168--177",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "2",

}

RIS

TY - JOUR

T1 - The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.

AU - Rogaeva, Ekaterina

AU - Meng, Yan

AU - Lee, Joseph H

AU - Gu, Yongjun

AU - Kawarai, Toshitaka

AU - Zou, Fanggeng

AU - Katayama, Taiichi

AU - Baldwin, Clinton T

AU - Cheng, Rong

AU - Hasegawa, Hiroshi

AU - Chen, Fusheng

AU - Shibata, Nobuto

AU - Lunetta, Kathryn L

AU - Pardossi-Piquard, Raphaelle

AU - Bohm, Christopher

AU - Wakutani, Yosuke

AU - Cupples, L Adrienne

AU - Cuenco, Karen T

AU - Green, Robert C

AU - Pinessi, Lorenzo

AU - Rainero, Innocenzo

AU - Sorbi, Sandro

AU - Bruni, Amalia

AU - Duara, Ranjan

AU - Friedland, Robert P

AU - Inzelberg, Rivka

AU - Hampe, Wolfgang

AU - Bujo, Hideaki

AU - Song, You-Qiang

AU - Andersen, Olav M

AU - Willnow, Thomas E

AU - Graff-Radford, Neill

AU - Petersen, Ronald C

AU - Dickson, Dennis

AU - Der, Sandy D

AU - Fraser, Paul E

AU - Schmitt-Ulms, Gerold

AU - Younkin, Steven

AU - Mayeux, Richard

AU - Farrer, Lindsay A

AU - Peter, St George-Hyslop

PY - 2007

Y1 - 2007

N2 - The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. We also show that SORL1 directs trafficking of APP into recycling pathways and that when SORL1 is underexpressed, APP is sorted into Abeta-generating compartments. These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.

AB - The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid beta peptide (Abeta) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at least two different clusters of intronic sequences within the SORL1 gene (also known as LR11 or SORLA) may regulate tissue-specific expression of SORL1. We also show that SORL1 directs trafficking of APP into recycling pathways and that when SORL1 is underexpressed, APP is sorted into Abeta-generating compartments. These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease.

M3 - SCORING: Zeitschriftenaufsatz

VL - 39

SP - 168

EP - 177

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 2

M1 - 2

ER -