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The neurobiology of gliomas: from cell biology to the development of therapeutic approaches

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The neurobiology of gliomas: from cell biology to the development of therapeutic approaches. / Westphal, Manfred; Lamszus, Katrin.

In: NAT REV NEUROSCI, Vol. 12, No. 9, 9, 01.09.2011, p. 495-508.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Westphal, M & Lamszus, K 2011, 'The neurobiology of gliomas: from cell biology to the development of therapeutic approaches', NAT REV NEUROSCI, vol. 12, no. 9, 9, pp. 495-508. https://doi.org/10.1038/nrn3060

APA

Westphal, M., & Lamszus, K. (2011). The neurobiology of gliomas: from cell biology to the development of therapeutic approaches. NAT REV NEUROSCI, 12(9), 495-508. [9]. https://doi.org/10.1038/nrn3060

Vancouver

Westphal M, Lamszus K. The neurobiology of gliomas: from cell biology to the development of therapeutic approaches. NAT REV NEUROSCI. 2011 Sep 1;12(9):495-508. 9. https://doi.org/10.1038/nrn3060

Bibtex

@article{a04774e111cb4149990c354561beb61f,
title = "The neurobiology of gliomas: from cell biology to the development of therapeutic approaches",
abstract = "Gliomas are the most common type of primary brain tumour and are often fast growing with a poor prognosis for the patient. Their complex cellular composition, diffuse invasiveness and capacity to escape therapies has challenged researchers for decades and hampered progress towards an effective treatment. Recent molecular characterization of tumour cells combined with new insights into cellular diversification that occurs during development, and the modelling of these processes in transgenic animals have enabled a more detailed understanding of the events that underlie gliomagenesis. Combining this enhanced understanding of the relationship between neural stem cell biology and the cell lineage relationships of tumour cells with model systems offers new opportunities to develop specific and effective therapies.",
keywords = "Animals, Humans, Brain Neoplasms/genetics/*pathology/*therapy, Cell Lineage/genetics, Gene Therapy/trends, Glioma/genetics/*pathology/*therapy, Neoplastic Stem Cells/*pathology, Animals, Humans, Brain Neoplasms/genetics/*pathology/*therapy, Cell Lineage/genetics, Gene Therapy/trends, Glioma/genetics/*pathology/*therapy, Neoplastic Stem Cells/*pathology",
author = "Manfred Westphal and Katrin Lamszus",
year = "2011",
month = sep,
day = "1",
doi = "10.1038/nrn3060",
language = "English",
volume = "12",
pages = "495--508",
journal = "NAT REV NEUROSCI",
issn = "1471-003X",
publisher = "NATURE PUBLISHING GROUP",
number = "9",

}

RIS

TY - JOUR

T1 - The neurobiology of gliomas: from cell biology to the development of therapeutic approaches

AU - Westphal, Manfred

AU - Lamszus, Katrin

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Gliomas are the most common type of primary brain tumour and are often fast growing with a poor prognosis for the patient. Their complex cellular composition, diffuse invasiveness and capacity to escape therapies has challenged researchers for decades and hampered progress towards an effective treatment. Recent molecular characterization of tumour cells combined with new insights into cellular diversification that occurs during development, and the modelling of these processes in transgenic animals have enabled a more detailed understanding of the events that underlie gliomagenesis. Combining this enhanced understanding of the relationship between neural stem cell biology and the cell lineage relationships of tumour cells with model systems offers new opportunities to develop specific and effective therapies.

AB - Gliomas are the most common type of primary brain tumour and are often fast growing with a poor prognosis for the patient. Their complex cellular composition, diffuse invasiveness and capacity to escape therapies has challenged researchers for decades and hampered progress towards an effective treatment. Recent molecular characterization of tumour cells combined with new insights into cellular diversification that occurs during development, and the modelling of these processes in transgenic animals have enabled a more detailed understanding of the events that underlie gliomagenesis. Combining this enhanced understanding of the relationship between neural stem cell biology and the cell lineage relationships of tumour cells with model systems offers new opportunities to develop specific and effective therapies.

KW - Animals

KW - Humans

KW - Brain Neoplasms/genetics/pathology/therapy

KW - Cell Lineage/genetics

KW - Gene Therapy/trends

KW - Glioma/genetics/pathology/therapy

KW - Neoplastic Stem Cells/pathology

KW - Animals

KW - Humans

KW - Brain Neoplasms/genetics/pathology/therapy

KW - Cell Lineage/genetics

KW - Gene Therapy/trends

KW - Glioma/genetics/pathology/therapy

KW - Neoplastic Stem Cells/pathology

U2 - 10.1038/nrn3060

DO - 10.1038/nrn3060

M3 - SCORING: Journal article

C2 - 21811295

VL - 12

SP - 495

EP - 508

JO - NAT REV NEUROSCI

JF - NAT REV NEUROSCI

SN - 1471-003X

IS - 9

M1 - 9

ER -