The neurobiology of gliomas: from cell biology to the development of therapeutic approaches
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The neurobiology of gliomas: from cell biology to the development of therapeutic approaches. / Westphal, Manfred; Lamszus, Katrin.
in: NAT REV NEUROSCI, Jahrgang 12, Nr. 9, 9, 01.09.2011, S. 495-508.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The neurobiology of gliomas: from cell biology to the development of therapeutic approaches
AU - Westphal, Manfred
AU - Lamszus, Katrin
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Gliomas are the most common type of primary brain tumour and are often fast growing with a poor prognosis for the patient. Their complex cellular composition, diffuse invasiveness and capacity to escape therapies has challenged researchers for decades and hampered progress towards an effective treatment. Recent molecular characterization of tumour cells combined with new insights into cellular diversification that occurs during development, and the modelling of these processes in transgenic animals have enabled a more detailed understanding of the events that underlie gliomagenesis. Combining this enhanced understanding of the relationship between neural stem cell biology and the cell lineage relationships of tumour cells with model systems offers new opportunities to develop specific and effective therapies.
AB - Gliomas are the most common type of primary brain tumour and are often fast growing with a poor prognosis for the patient. Their complex cellular composition, diffuse invasiveness and capacity to escape therapies has challenged researchers for decades and hampered progress towards an effective treatment. Recent molecular characterization of tumour cells combined with new insights into cellular diversification that occurs during development, and the modelling of these processes in transgenic animals have enabled a more detailed understanding of the events that underlie gliomagenesis. Combining this enhanced understanding of the relationship between neural stem cell biology and the cell lineage relationships of tumour cells with model systems offers new opportunities to develop specific and effective therapies.
KW - Animals
KW - Humans
KW - Brain Neoplasms/genetics/pathology/therapy
KW - Cell Lineage/genetics
KW - Gene Therapy/trends
KW - Glioma/genetics/pathology/therapy
KW - Neoplastic Stem Cells/pathology
KW - Animals
KW - Humans
KW - Brain Neoplasms/genetics/pathology/therapy
KW - Cell Lineage/genetics
KW - Gene Therapy/trends
KW - Glioma/genetics/pathology/therapy
KW - Neoplastic Stem Cells/pathology
U2 - 10.1038/nrn3060
DO - 10.1038/nrn3060
M3 - SCORING: Journal article
C2 - 21811295
VL - 12
SP - 495
EP - 508
JO - NAT REV NEUROSCI
JF - NAT REV NEUROSCI
SN - 1471-003X
IS - 9
M1 - 9
ER -