The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth.

Ralf Kleene; H Yang; M Kutsche; M Schachner

The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth.

Standard

The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. / Kleene, Ralf; Yang, H; Kutsche, M; Schachner, M.

In: J BIOL CHEM, Vol. 276, No. 24, 24, 2001, p. 21656-21663.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kleene, R, Yang, H, Kutsche, M & Schachner, M 2001, 'The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth.', J BIOL CHEM, vol. 276, no. 24, 24, pp. 21656-21663. <http://www.ncbi.nlm.nih.gov/pubmed/11283023?dopt=Citation>

APA

Kleene, R., Yang, H., Kutsche, M., & Schachner, M. (2001). The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J BIOL CHEM, 276(24), 21656-21663. [24]. http://www.ncbi.nlm.nih.gov/pubmed/11283023?dopt=Citation

Vancouver

Kleene R, Yang H, Kutsche M, Schachner M. The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. J BIOL CHEM. 2001;276(24):21656-21663. 24.

Bibtex

@article{f251612fb5644b12a26f4730f308d9c8,

title = "The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth.",

abstract = "Among the recognition molecules that determine a neuron's interaction with other cells, L1 and CD24 have been suggested to cooperate with each other in neurite outgrowth and signal transduction. Here we report that binding of CD24 to L1 depends on alpha2,3-sialic acid on CD24, which determines the CD24 induced and cell type-specific promotion or inhibition of neurite outgrowth. Using knockout mutants, we could show that the CD24-induced effects on neurite outgrowth are mediated via L1, and not GPI-linked CD24, by trans-interaction of L1 with sialylated CD24. This glycoform is excluded together with L1 from raft microdomains, suggesting that molecular compartmentation in the surface membrane could play a role in signal transduction.",

keywords = "Animals, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Kinetics, Rats, Amino Acid Sequence, Molecular Sequence Data, Binding Sites, Models, Molecular, Sequence Homology, Amino Acid, Sequence Alignment, Protein Conformation, Xenopus, Brain/*physiology, Peptide Fragments/chemistry, Antigens, CD/chemistry/genetics/*physiology, Antigens, CD24, Cell Membrane/physiology, Chickens, Consensus Sequence, Fishes, Glycosylphosphatidylinositols/metabolism, Leukocyte L1 Antigen Complex, Membrane Glycoproteins/deficiency/genetics/*physiology, Mice, Inbred ICR, N-Acetylneuraminic Acid/metabolism, Neural Cell Adhesion Molecules/deficiency/genetics/*physiology, Neurites/*physiology/ultrastructure, Recombinant Proteins/chemistry/metabolism, Animals, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Kinetics, Rats, Amino Acid Sequence, Molecular Sequence Data, Binding Sites, Models, Molecular, Sequence Homology, Amino Acid, Sequence Alignment, Protein Conformation, Xenopus, Brain/*physiology, Peptide Fragments/chemistry, Antigens, CD/chemistry/genetics/*physiology, Antigens, CD24, Cell Membrane/physiology, Chickens, Consensus Sequence, Fishes, Glycosylphosphatidylinositols/metabolism, Leukocyte L1 Antigen Complex, Membrane Glycoproteins/deficiency/genetics/*physiology, Mice, Inbred ICR, N-Acetylneuraminic Acid/metabolism, Neural Cell Adhesion Molecules/deficiency/genetics/*physiology, Neurites/*physiology/ultrastructure, Recombinant Proteins/chemistry/metabolism",

author = "Ralf Kleene and H Yang and M Kutsche and M Schachner",

year = "2001",

language = "English",

volume = "276",

pages = "21656--21663",

journal = "J BIOL CHEM",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "24",

}

RIS

TY - JOUR

T1 - The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth.

AU - Kleene, Ralf

AU - Yang, H

AU - Kutsche, M

AU - Schachner, M

PY - 2001

Y1 - 2001

N2 - Among the recognition molecules that determine a neuron's interaction with other cells, L1 and CD24 have been suggested to cooperate with each other in neurite outgrowth and signal transduction. Here we report that binding of CD24 to L1 depends on alpha2,3-sialic acid on CD24, which determines the CD24 induced and cell type-specific promotion or inhibition of neurite outgrowth. Using knockout mutants, we could show that the CD24-induced effects on neurite outgrowth are mediated via L1, and not GPI-linked CD24, by trans-interaction of L1 with sialylated CD24. This glycoform is excluded together with L1 from raft microdomains, suggesting that molecular compartmentation in the surface membrane could play a role in signal transduction.

AB - Among the recognition molecules that determine a neuron's interaction with other cells, L1 and CD24 have been suggested to cooperate with each other in neurite outgrowth and signal transduction. Here we report that binding of CD24 to L1 depends on alpha2,3-sialic acid on CD24, which determines the CD24 induced and cell type-specific promotion or inhibition of neurite outgrowth. Using knockout mutants, we could show that the CD24-induced effects on neurite outgrowth are mediated via L1, and not GPI-linked CD24, by trans-interaction of L1 with sialylated CD24. This glycoform is excluded together with L1 from raft microdomains, suggesting that molecular compartmentation in the surface membrane could play a role in signal transduction.

KW - Animals

KW - Humans

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Kinetics

KW - Rats

KW - Amino Acid Sequence

KW - Molecular Sequence Data

KW - Binding Sites

KW - Models, Molecular

KW - Sequence Homology, Amino Acid

KW - Sequence Alignment

KW - Protein Conformation

KW - Xenopus

KW - Brain/physiology

KW - Peptide Fragments/chemistry

KW - Antigens, CD/chemistry/genetics/physiology

KW - Antigens, CD24

KW - Cell Membrane/physiology

KW - Chickens

KW - Consensus Sequence

KW - Fishes

KW - Glycosylphosphatidylinositols/metabolism

KW - Leukocyte L1 Antigen Complex

KW - Membrane Glycoproteins/deficiency/genetics/physiology

KW - Mice, Inbred ICR

KW - N-Acetylneuraminic Acid/metabolism

KW - Neural Cell Adhesion Molecules/deficiency/genetics/physiology

KW - Neurites/physiology/ultrastructure

KW - Recombinant Proteins/chemistry/metabolism