The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth.
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The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth. / Kleene, Ralf; Yang, H; Kutsche, M; Schachner, M.
in: J BIOL CHEM, Jahrgang 276, Nr. 24, 24, 2001, S. 21656-21663.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The neural recognition molecule L1 is a sialic acid-binding lectin for CD24, which induces promotion and inhibition of neurite outgrowth.
AU - Kleene, Ralf
AU - Yang, H
AU - Kutsche, M
AU - Schachner, M
PY - 2001
Y1 - 2001
N2 - Among the recognition molecules that determine a neuron's interaction with other cells, L1 and CD24 have been suggested to cooperate with each other in neurite outgrowth and signal transduction. Here we report that binding of CD24 to L1 depends on alpha2,3-sialic acid on CD24, which determines the CD24 induced and cell type-specific promotion or inhibition of neurite outgrowth. Using knockout mutants, we could show that the CD24-induced effects on neurite outgrowth are mediated via L1, and not GPI-linked CD24, by trans-interaction of L1 with sialylated CD24. This glycoform is excluded together with L1 from raft microdomains, suggesting that molecular compartmentation in the surface membrane could play a role in signal transduction.
AB - Among the recognition molecules that determine a neuron's interaction with other cells, L1 and CD24 have been suggested to cooperate with each other in neurite outgrowth and signal transduction. Here we report that binding of CD24 to L1 depends on alpha2,3-sialic acid on CD24, which determines the CD24 induced and cell type-specific promotion or inhibition of neurite outgrowth. Using knockout mutants, we could show that the CD24-induced effects on neurite outgrowth are mediated via L1, and not GPI-linked CD24, by trans-interaction of L1 with sialylated CD24. This glycoform is excluded together with L1 from raft microdomains, suggesting that molecular compartmentation in the surface membrane could play a role in signal transduction.
KW - Animals
KW - Humans
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Kinetics
KW - Rats
KW - Amino Acid Sequence
KW - Molecular Sequence Data
KW - Binding Sites
KW - Models, Molecular
KW - Sequence Homology, Amino Acid
KW - Sequence Alignment
KW - Protein Conformation
KW - Xenopus
KW - Brain/physiology
KW - Peptide Fragments/chemistry
KW - Antigens, CD/chemistry/genetics/physiology
KW - Antigens, CD24
KW - Cell Membrane/physiology
KW - Chickens
KW - Consensus Sequence
KW - Fishes
KW - Glycosylphosphatidylinositols/metabolism
KW - Leukocyte L1 Antigen Complex
KW - Membrane Glycoproteins/deficiency/genetics/physiology
KW - Mice, Inbred ICR
KW - N-Acetylneuraminic Acid/metabolism
KW - Neural Cell Adhesion Molecules/deficiency/genetics/physiology
KW - Neurites/physiology/ultrastructure
KW - Recombinant Proteins/chemistry/metabolism
KW - Animals
KW - Humans
KW - Mice
KW - Mice, Inbred C57BL
KW - Mice, Knockout
KW - Kinetics
KW - Rats
KW - Amino Acid Sequence
KW - Molecular Sequence Data
KW - Binding Sites
KW - Models, Molecular
KW - Sequence Homology, Amino Acid
KW - Sequence Alignment
KW - Protein Conformation
KW - Xenopus
KW - Brain/physiology
KW - Peptide Fragments/chemistry
KW - Antigens, CD/chemistry/genetics/physiology
KW - Antigens, CD24
KW - Cell Membrane/physiology
KW - Chickens
KW - Consensus Sequence
KW - Fishes
KW - Glycosylphosphatidylinositols/metabolism
KW - Leukocyte L1 Antigen Complex
KW - Membrane Glycoproteins/deficiency/genetics/physiology
KW - Mice, Inbred ICR
KW - N-Acetylneuraminic Acid/metabolism
KW - Neural Cell Adhesion Molecules/deficiency/genetics/physiology
KW - Neurites/physiology/ultrastructure
KW - Recombinant Proteins/chemistry/metabolism
M3 - SCORING: Journal article
VL - 276
SP - 21656
EP - 21663
JO - J BIOL CHEM
JF - J BIOL CHEM
SN - 0021-9258
IS - 24
M1 - 24
ER -