The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders
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The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders. / Bernstein, Hans-Gert; Smalla, Karl-Heinz; Keilhoff, Gerburg; Dobrowolny, Henrik; Kreutz, Michael R; Steiner, Johann.
In: J CHEM NEUROANAT, Vol. 132, 10.2023, p. 102321.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders
AU - Bernstein, Hans-Gert
AU - Smalla, Karl-Heinz
AU - Keilhoff, Gerburg
AU - Dobrowolny, Henrik
AU - Kreutz, Michael R
AU - Steiner, Johann
N1 - Copyright © 2023 Elsevier B.V. All rights reserved.
PY - 2023/10
Y1 - 2023/10
N2 - Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are nearly ubiquitously expressed. They are localized in mitochondria, cytosol and cell nuclei. In the healthy CNS, they occur in neurons and non-neuronal cells (oligodendrocytes, astrocytes, microglia, and endothelial cells) and fulfill pivotal functions in brain development and aging, the regulation of brain metabolism, maintenance of structural integrity, synapse formation, aminoacidergic neurotransmission and, probably, regulation of brain action of certain hypothalamic-pituitary hormones.With regard to the diseased brain there is increasing evidence that prohibitins are prominently involved in numerous major diseases of the CNS, which are summarized and discussed in the present review (brain tumors, neurotropic viruses, Alzheimer disease, Down syndrome, Fronto-temporal and vascular dementia, dementia with Lewy bodies, Parkinson disease, Huntington disease, Multiple sclerosis, Amyotrophic lateral sclerosis, stroke, alcohol use disorder, schizophrenia and autism). Unfortunately, there is no PHB-targeted therapy available for any of these diseases.
AB - Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are nearly ubiquitously expressed. They are localized in mitochondria, cytosol and cell nuclei. In the healthy CNS, they occur in neurons and non-neuronal cells (oligodendrocytes, astrocytes, microglia, and endothelial cells) and fulfill pivotal functions in brain development and aging, the regulation of brain metabolism, maintenance of structural integrity, synapse formation, aminoacidergic neurotransmission and, probably, regulation of brain action of certain hypothalamic-pituitary hormones.With regard to the diseased brain there is increasing evidence that prohibitins are prominently involved in numerous major diseases of the CNS, which are summarized and discussed in the present review (brain tumors, neurotropic viruses, Alzheimer disease, Down syndrome, Fronto-temporal and vascular dementia, dementia with Lewy bodies, Parkinson disease, Huntington disease, Multiple sclerosis, Amyotrophic lateral sclerosis, stroke, alcohol use disorder, schizophrenia and autism). Unfortunately, there is no PHB-targeted therapy available for any of these diseases.
U2 - 10.1016/j.jchemneu.2023.102321
DO - 10.1016/j.jchemneu.2023.102321
M3 - SCORING: Review article
C2 - 37524128
VL - 132
SP - 102321
JO - J CHEM NEUROANAT
JF - J CHEM NEUROANAT
SN - 0891-0618
ER -