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The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders

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The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders. / Bernstein, Hans-Gert; Smalla, Karl-Heinz; Keilhoff, Gerburg; Dobrowolny, Henrik; Kreutz, Michael R; Steiner, Johann.

in: J CHEM NEUROANAT, Jahrgang 132, 10.2023, S. 102321.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Bernstein, H-G, Smalla, K-H, Keilhoff, G, Dobrowolny, H, Kreutz, MR & Steiner, J 2023, 'The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders', J CHEM NEUROANAT, Jg. 132, S. 102321. https://doi.org/10.1016/j.jchemneu.2023.102321

APA

Bernstein, H-G., Smalla, K-H., Keilhoff, G., Dobrowolny, H., Kreutz, M. R., & Steiner, J. (2023). The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders. J CHEM NEUROANAT, 132, 102321. https://doi.org/10.1016/j.jchemneu.2023.102321

Vancouver

Bernstein H-G, Smalla K-H, Keilhoff G, Dobrowolny H, Kreutz MR, Steiner J. The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders. J CHEM NEUROANAT. 2023 Okt;132:102321. https://doi.org/10.1016/j.jchemneu.2023.102321

Bibtex

@article{c0b33e0c86d047f281553b24a003a9d3,
title = "The many {"}Neurofaces{"} of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders",
abstract = "Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are nearly ubiquitously expressed. They are localized in mitochondria, cytosol and cell nuclei. In the healthy CNS, they occur in neurons and non-neuronal cells (oligodendrocytes, astrocytes, microglia, and endothelial cells) and fulfill pivotal functions in brain development and aging, the regulation of brain metabolism, maintenance of structural integrity, synapse formation, aminoacidergic neurotransmission and, probably, regulation of brain action of certain hypothalamic-pituitary hormones.With regard to the diseased brain there is increasing evidence that prohibitins are prominently involved in numerous major diseases of the CNS, which are summarized and discussed in the present review (brain tumors, neurotropic viruses, Alzheimer disease, Down syndrome, Fronto-temporal and vascular dementia, dementia with Lewy bodies, Parkinson disease, Huntington disease, Multiple sclerosis, Amyotrophic lateral sclerosis, stroke, alcohol use disorder, schizophrenia and autism). Unfortunately, there is no PHB-targeted therapy available for any of these diseases.",
author = "Hans-Gert Bernstein and Karl-Heinz Smalla and Gerburg Keilhoff and Henrik Dobrowolny and Kreutz, {Michael R} and Johann Steiner",
note = "Copyright {\textcopyright} 2023 Elsevier B.V. All rights reserved.",
year = "2023",
month = oct,
doi = "10.1016/j.jchemneu.2023.102321",
language = "English",
volume = "132",
pages = "102321",
journal = "J CHEM NEUROANAT",
issn = "0891-0618",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders

AU - Bernstein, Hans-Gert

AU - Smalla, Karl-Heinz

AU - Keilhoff, Gerburg

AU - Dobrowolny, Henrik

AU - Kreutz, Michael R

AU - Steiner, Johann

N1 - Copyright © 2023 Elsevier B.V. All rights reserved.

PY - 2023/10

Y1 - 2023/10

N2 - Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are nearly ubiquitously expressed. They are localized in mitochondria, cytosol and cell nuclei. In the healthy CNS, they occur in neurons and non-neuronal cells (oligodendrocytes, astrocytes, microglia, and endothelial cells) and fulfill pivotal functions in brain development and aging, the regulation of brain metabolism, maintenance of structural integrity, synapse formation, aminoacidergic neurotransmission and, probably, regulation of brain action of certain hypothalamic-pituitary hormones.With regard to the diseased brain there is increasing evidence that prohibitins are prominently involved in numerous major diseases of the CNS, which are summarized and discussed in the present review (brain tumors, neurotropic viruses, Alzheimer disease, Down syndrome, Fronto-temporal and vascular dementia, dementia with Lewy bodies, Parkinson disease, Huntington disease, Multiple sclerosis, Amyotrophic lateral sclerosis, stroke, alcohol use disorder, schizophrenia and autism). Unfortunately, there is no PHB-targeted therapy available for any of these diseases.

AB - Prohibitin 1 (PHB1) and prohibitin 2 (PHB2) are proteins that are nearly ubiquitously expressed. They are localized in mitochondria, cytosol and cell nuclei. In the healthy CNS, they occur in neurons and non-neuronal cells (oligodendrocytes, astrocytes, microglia, and endothelial cells) and fulfill pivotal functions in brain development and aging, the regulation of brain metabolism, maintenance of structural integrity, synapse formation, aminoacidergic neurotransmission and, probably, regulation of brain action of certain hypothalamic-pituitary hormones.With regard to the diseased brain there is increasing evidence that prohibitins are prominently involved in numerous major diseases of the CNS, which are summarized and discussed in the present review (brain tumors, neurotropic viruses, Alzheimer disease, Down syndrome, Fronto-temporal and vascular dementia, dementia with Lewy bodies, Parkinson disease, Huntington disease, Multiple sclerosis, Amyotrophic lateral sclerosis, stroke, alcohol use disorder, schizophrenia and autism). Unfortunately, there is no PHB-targeted therapy available for any of these diseases.

U2 - 10.1016/j.jchemneu.2023.102321

DO - 10.1016/j.jchemneu.2023.102321

M3 - SCORING: Review article

C2 - 37524128

VL - 132

SP - 102321

JO - J CHEM NEUROANAT

JF - J CHEM NEUROANAT

SN - 0891-0618

ER -