Research ExplorerPublicationsThe main contributor to the upswing of survival in locally a...

The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database

Standard

The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database. / Li, Yuqiang; Zhao, Lilan; Güngör, Cenap; Tan, Fengbo; Zhou, Zhongyi; Li, Chenglong; Song, Xiangping; Wang, Dan; Pei, Qian; Liu, Wenxue.

In: THER ADV GASTROENTER, Vol. 12, 2019, p. 1756284819862154.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Li, Y, Zhao, L, Güngör, C, Tan, F, Zhou, Z, Li, C, Song, X, Wang, D, Pei, Q & Liu, W 2019, 'The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database', THER ADV GASTROENTER, vol. 12, pp. 1756284819862154. https://doi.org/10.1177/1756284819862154

APA

Li, Y., Zhao, L., Güngör, C., Tan, F., Zhou, Z., Li, C., Song, X., Wang, D., Pei, Q., & Liu, W. (2019). The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database. THER ADV GASTROENTER, 12, 1756284819862154. https://doi.org/10.1177/1756284819862154

Vancouver

Li Y, Zhao L, Güngör C, Tan F, Zhou Z, Li C et al. The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database. THER ADV GASTROENTER. 2019;12:1756284819862154. https://doi.org/10.1177/1756284819862154

Bibtex

@article{5ec7f1b810d74d4ab7aee45376e0df27,
title = "The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database",
abstract = "Background: There is no conclusion about the most important contributor to the upswing of locally advanced colorectal cancer (LACRC) survival.Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) database was extracted to identify colorectal adenocarcinoma cancer patients at stage II and III diagnosed in the two periods 1989-1990 and 2009-2010. The statistical methods included Pearson's chi-squared test, log-rank test, Cox regression model and propensity score matching.Results: The Cox regression model showed that hazard ratio (HR) of non-surgery dropped from 11.529 to 3.469 in right colon cancer (RCC), 5.214 to 2.652 in left colon cancer (LCC) and 3.275 to 3.269 in rectal cancer (RC) from 1989-1990 to 2009-2010. The 95% confidence intervals (CIs) for surgical resection in 2009-2010 were narrower than those in 1989-1990. HR became greater in LACRC without chemotherapy (from 1.337 to 1.779 in RCC, 1.269 to 2.017 in LCC, 1.317 to 1.811 in RC). There was no overlapping about the 95% CI of chemotherapy between the two groups. The progress of surgery was not linked to the improvement of overall survival (OS) of RCC (p = 0.303) and RC (p = 0.660). Chemotherapy had a significant association with OS of all colorectal cancer (CRC) patients (p = 0.017 in RCC; p = 0.006 in LCC; p = 0.001 in RC).Conclusions: Advancements in chemotherapy regimen were the main contributor to the upswing of CRC survival. The improvements in surgery had a limited effect on improvements in CRC survival.",
author = "Yuqiang Li and Lilan Zhao and Cenap G{\"u}ng{\"o}r and Fengbo Tan and Zhongyi Zhou and Chenglong Li and Xiangping Song and Dan Wang and Qian Pei and Wenxue Liu",
year = "2019",
doi = "10.1177/1756284819862154",
language = "English",
volume = "12",
pages = "1756284819862154",
journal = "THER ADV GASTROENTER",
issn = "1756-283X",
publisher = "SAGE Publications",

}

RIS

TY - JOUR

T1 - The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database

AU - Li, Yuqiang

AU - Zhao, Lilan

AU - Güngör, Cenap

AU - Tan, Fengbo

AU - Zhou, Zhongyi

AU - Li, Chenglong

AU - Song, Xiangping

AU - Wang, Dan

AU - Pei, Qian

AU - Liu, Wenxue

PY - 2019

Y1 - 2019

N2 - Background: There is no conclusion about the most important contributor to the upswing of locally advanced colorectal cancer (LACRC) survival.Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) database was extracted to identify colorectal adenocarcinoma cancer patients at stage II and III diagnosed in the two periods 1989-1990 and 2009-2010. The statistical methods included Pearson's chi-squared test, log-rank test, Cox regression model and propensity score matching.Results: The Cox regression model showed that hazard ratio (HR) of non-surgery dropped from 11.529 to 3.469 in right colon cancer (RCC), 5.214 to 2.652 in left colon cancer (LCC) and 3.275 to 3.269 in rectal cancer (RC) from 1989-1990 to 2009-2010. The 95% confidence intervals (CIs) for surgical resection in 2009-2010 were narrower than those in 1989-1990. HR became greater in LACRC without chemotherapy (from 1.337 to 1.779 in RCC, 1.269 to 2.017 in LCC, 1.317 to 1.811 in RC). There was no overlapping about the 95% CI of chemotherapy between the two groups. The progress of surgery was not linked to the improvement of overall survival (OS) of RCC (p = 0.303) and RC (p = 0.660). Chemotherapy had a significant association with OS of all colorectal cancer (CRC) patients (p = 0.017 in RCC; p = 0.006 in LCC; p = 0.001 in RC).Conclusions: Advancements in chemotherapy regimen were the main contributor to the upswing of CRC survival. The improvements in surgery had a limited effect on improvements in CRC survival.

AB - Background: There is no conclusion about the most important contributor to the upswing of locally advanced colorectal cancer (LACRC) survival.Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) database was extracted to identify colorectal adenocarcinoma cancer patients at stage II and III diagnosed in the two periods 1989-1990 and 2009-2010. The statistical methods included Pearson's chi-squared test, log-rank test, Cox regression model and propensity score matching.Results: The Cox regression model showed that hazard ratio (HR) of non-surgery dropped from 11.529 to 3.469 in right colon cancer (RCC), 5.214 to 2.652 in left colon cancer (LCC) and 3.275 to 3.269 in rectal cancer (RC) from 1989-1990 to 2009-2010. The 95% confidence intervals (CIs) for surgical resection in 2009-2010 were narrower than those in 1989-1990. HR became greater in LACRC without chemotherapy (from 1.337 to 1.779 in RCC, 1.269 to 2.017 in LCC, 1.317 to 1.811 in RC). There was no overlapping about the 95% CI of chemotherapy between the two groups. The progress of surgery was not linked to the improvement of overall survival (OS) of RCC (p = 0.303) and RC (p = 0.660). Chemotherapy had a significant association with OS of all colorectal cancer (CRC) patients (p = 0.017 in RCC; p = 0.006 in LCC; p = 0.001 in RC).Conclusions: Advancements in chemotherapy regimen were the main contributor to the upswing of CRC survival. The improvements in surgery had a limited effect on improvements in CRC survival.

U2 - 10.1177/1756284819862154

DO - 10.1177/1756284819862154

M3 - SCORING: Journal article

C2 - 31360223

VL - 12

SP - 1756284819862154

JO - THER ADV GASTROENTER

JF - THER ADV GASTROENTER

SN - 1756-283X

ER -