The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database
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The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database. / Li, Yuqiang; Zhao, Lilan; Güngör, Cenap; Tan, Fengbo; Zhou, Zhongyi; Li, Chenglong; Song, Xiangping; Wang, Dan; Pei, Qian; Liu, Wenxue.
in: THER ADV GASTROENTER, Jahrgang 12, 2019, S. 1756284819862154.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - The main contributor to the upswing of survival in locally advanced colorectal cancer: an analysis of the SEER database
AU - Li, Yuqiang
AU - Zhao, Lilan
AU - Güngör, Cenap
AU - Tan, Fengbo
AU - Zhou, Zhongyi
AU - Li, Chenglong
AU - Song, Xiangping
AU - Wang, Dan
AU - Pei, Qian
AU - Liu, Wenxue
PY - 2019
Y1 - 2019
N2 - Background: There is no conclusion about the most important contributor to the upswing of locally advanced colorectal cancer (LACRC) survival.Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) database was extracted to identify colorectal adenocarcinoma cancer patients at stage II and III diagnosed in the two periods 1989-1990 and 2009-2010. The statistical methods included Pearson's chi-squared test, log-rank test, Cox regression model and propensity score matching.Results: The Cox regression model showed that hazard ratio (HR) of non-surgery dropped from 11.529 to 3.469 in right colon cancer (RCC), 5.214 to 2.652 in left colon cancer (LCC) and 3.275 to 3.269 in rectal cancer (RC) from 1989-1990 to 2009-2010. The 95% confidence intervals (CIs) for surgical resection in 2009-2010 were narrower than those in 1989-1990. HR became greater in LACRC without chemotherapy (from 1.337 to 1.779 in RCC, 1.269 to 2.017 in LCC, 1.317 to 1.811 in RC). There was no overlapping about the 95% CI of chemotherapy between the two groups. The progress of surgery was not linked to the improvement of overall survival (OS) of RCC (p = 0.303) and RC (p = 0.660). Chemotherapy had a significant association with OS of all colorectal cancer (CRC) patients (p = 0.017 in RCC; p = 0.006 in LCC; p = 0.001 in RC).Conclusions: Advancements in chemotherapy regimen were the main contributor to the upswing of CRC survival. The improvements in surgery had a limited effect on improvements in CRC survival.
AB - Background: There is no conclusion about the most important contributor to the upswing of locally advanced colorectal cancer (LACRC) survival.Methods: Data from the Surveillance, Epidemiology, and End Results (SEER) database was extracted to identify colorectal adenocarcinoma cancer patients at stage II and III diagnosed in the two periods 1989-1990 and 2009-2010. The statistical methods included Pearson's chi-squared test, log-rank test, Cox regression model and propensity score matching.Results: The Cox regression model showed that hazard ratio (HR) of non-surgery dropped from 11.529 to 3.469 in right colon cancer (RCC), 5.214 to 2.652 in left colon cancer (LCC) and 3.275 to 3.269 in rectal cancer (RC) from 1989-1990 to 2009-2010. The 95% confidence intervals (CIs) for surgical resection in 2009-2010 were narrower than those in 1989-1990. HR became greater in LACRC without chemotherapy (from 1.337 to 1.779 in RCC, 1.269 to 2.017 in LCC, 1.317 to 1.811 in RC). There was no overlapping about the 95% CI of chemotherapy between the two groups. The progress of surgery was not linked to the improvement of overall survival (OS) of RCC (p = 0.303) and RC (p = 0.660). Chemotherapy had a significant association with OS of all colorectal cancer (CRC) patients (p = 0.017 in RCC; p = 0.006 in LCC; p = 0.001 in RC).Conclusions: Advancements in chemotherapy regimen were the main contributor to the upswing of CRC survival. The improvements in surgery had a limited effect on improvements in CRC survival.
U2 - 10.1177/1756284819862154
DO - 10.1177/1756284819862154
M3 - SCORING: Journal article
C2 - 31360223
VL - 12
SP - 1756284819862154
JO - THER ADV GASTROENTER
JF - THER ADV GASTROENTER
SN - 1756-283X
ER -