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The local cytokine and chemokine milieu within malignant effusions.

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The local cytokine and chemokine milieu within malignant effusions. / Atanackovic, Djordje; Cao, Yanran; Kim, Ji-Won; Brandl, Stephan; Thoem, Ina; Faltz, Christiane; Hildebrandt, York; Bartels, Katrin; De Weerth, Andreas; Hegewisch-Becker, Susanna; Hossfeld, Dieter; Bokemeyer, Carsten.

In: TUMOR BIOL, Vol. 29, No. 2, 2, 2008, p. 93-104.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Atanackovic, D, Cao, Y, Kim, J-W, Brandl, S, Thoem, I, Faltz, C, Hildebrandt, Y, Bartels, K, De Weerth, A, Hegewisch-Becker, S, Hossfeld, D & Bokemeyer, C 2008, 'The local cytokine and chemokine milieu within malignant effusions.', TUMOR BIOL, vol. 29, no. 2, 2, pp. 93-104. <http://www.ncbi.nlm.nih.gov/pubmed/18515987?dopt=Citation>

APA

Atanackovic, D., Cao, Y., Kim, J-W., Brandl, S., Thoem, I., Faltz, C., Hildebrandt, Y., Bartels, K., De Weerth, A., Hegewisch-Becker, S., Hossfeld, D., & Bokemeyer, C. (2008). The local cytokine and chemokine milieu within malignant effusions. TUMOR BIOL, 29(2), 93-104. [2]. http://www.ncbi.nlm.nih.gov/pubmed/18515987?dopt=Citation

Vancouver

Atanackovic D, Cao Y, Kim J-W, Brandl S, Thoem I, Faltz C et al. The local cytokine and chemokine milieu within malignant effusions. TUMOR BIOL. 2008;29(2):93-104. 2.

Bibtex

@article{1b8a1bf53afd479ebb6d5c500d272f72,
title = "The local cytokine and chemokine milieu within malignant effusions.",
abstract = "BACKGROUND/AIMS: Malignant effusions offer a unique opportunity for the study of interactions between the human immune system and cancer. We have recently demonstrated that malignant effusions are characterized by an accumulation of T cells expressing chemokine receptors such as CCR4, which is commonly found on Th2 cells. In contrast, effector T cells expressing chemokine receptors typical for Th1 cells, such as CCR5, showed a diminished homing into malignant effusions. METHODS: We analyzed concentrations of 12 different cytokines and 9 chemokines within malignant and nonmalignant effusions and investigated cytokine expression by effusion-infiltrating leukocytes. RESULTS: We observed that concentrations of the immunoregulatory cytokine TGF-beta(1) and of angiogenic factors VEGF and IL-8 were markedly increased within effusions caused by malignancies. However, we did not observe signs of a typical Th1 or Th2 milieu. Analyzing concentrations of 9 different chemokines, we found elevated concentrations of the chemokines MDC, eotaxin, I-TAC, and MCP-1 in malignant effusions. Interestingly, tumor-infiltrating leukocytes themselves seemed to contribute strongly to the creation of a distinct cytokine/chemokine pattern within cancer-related effusions. Additional analyses suggested that this cytokine/chemokine milieu might support an enrichment of immunosuppressive leukocytes. CONCLUSION: The local cytokine and chemokine milieu within malignant effusions seems to promote angiogenesis and to block an efficient immune-mediated antitumor response. An elimination of such tumor-promoting influences will be necessary in order to transform local immunotolerance into clinically relevant immune recognition of tumors causing malignant effusions.",
author = "Djordje Atanackovic and Yanran Cao and Ji-Won Kim and Stephan Brandl and Ina Thoem and Christiane Faltz and York Hildebrandt and Katrin Bartels and {De Weerth}, Andreas and Susanna Hegewisch-Becker and Dieter Hossfeld and Carsten Bokemeyer",
year = "2008",
language = "Deutsch",
volume = "29",
pages = "93--104",
journal = "TUMOR BIOL",
issn = "1010-4283",
publisher = "Springer Netherlands",
number = "2",

}

RIS

TY - JOUR

T1 - The local cytokine and chemokine milieu within malignant effusions.

AU - Atanackovic, Djordje

AU - Cao, Yanran

AU - Kim, Ji-Won

AU - Brandl, Stephan

AU - Thoem, Ina

AU - Faltz, Christiane

AU - Hildebrandt, York

AU - Bartels, Katrin

AU - De Weerth, Andreas

AU - Hegewisch-Becker, Susanna

AU - Hossfeld, Dieter

AU - Bokemeyer, Carsten

PY - 2008

Y1 - 2008

N2 - BACKGROUND/AIMS: Malignant effusions offer a unique opportunity for the study of interactions between the human immune system and cancer. We have recently demonstrated that malignant effusions are characterized by an accumulation of T cells expressing chemokine receptors such as CCR4, which is commonly found on Th2 cells. In contrast, effector T cells expressing chemokine receptors typical for Th1 cells, such as CCR5, showed a diminished homing into malignant effusions. METHODS: We analyzed concentrations of 12 different cytokines and 9 chemokines within malignant and nonmalignant effusions and investigated cytokine expression by effusion-infiltrating leukocytes. RESULTS: We observed that concentrations of the immunoregulatory cytokine TGF-beta(1) and of angiogenic factors VEGF and IL-8 were markedly increased within effusions caused by malignancies. However, we did not observe signs of a typical Th1 or Th2 milieu. Analyzing concentrations of 9 different chemokines, we found elevated concentrations of the chemokines MDC, eotaxin, I-TAC, and MCP-1 in malignant effusions. Interestingly, tumor-infiltrating leukocytes themselves seemed to contribute strongly to the creation of a distinct cytokine/chemokine pattern within cancer-related effusions. Additional analyses suggested that this cytokine/chemokine milieu might support an enrichment of immunosuppressive leukocytes. CONCLUSION: The local cytokine and chemokine milieu within malignant effusions seems to promote angiogenesis and to block an efficient immune-mediated antitumor response. An elimination of such tumor-promoting influences will be necessary in order to transform local immunotolerance into clinically relevant immune recognition of tumors causing malignant effusions.

AB - BACKGROUND/AIMS: Malignant effusions offer a unique opportunity for the study of interactions between the human immune system and cancer. We have recently demonstrated that malignant effusions are characterized by an accumulation of T cells expressing chemokine receptors such as CCR4, which is commonly found on Th2 cells. In contrast, effector T cells expressing chemokine receptors typical for Th1 cells, such as CCR5, showed a diminished homing into malignant effusions. METHODS: We analyzed concentrations of 12 different cytokines and 9 chemokines within malignant and nonmalignant effusions and investigated cytokine expression by effusion-infiltrating leukocytes. RESULTS: We observed that concentrations of the immunoregulatory cytokine TGF-beta(1) and of angiogenic factors VEGF and IL-8 were markedly increased within effusions caused by malignancies. However, we did not observe signs of a typical Th1 or Th2 milieu. Analyzing concentrations of 9 different chemokines, we found elevated concentrations of the chemokines MDC, eotaxin, I-TAC, and MCP-1 in malignant effusions. Interestingly, tumor-infiltrating leukocytes themselves seemed to contribute strongly to the creation of a distinct cytokine/chemokine pattern within cancer-related effusions. Additional analyses suggested that this cytokine/chemokine milieu might support an enrichment of immunosuppressive leukocytes. CONCLUSION: The local cytokine and chemokine milieu within malignant effusions seems to promote angiogenesis and to block an efficient immune-mediated antitumor response. An elimination of such tumor-promoting influences will be necessary in order to transform local immunotolerance into clinically relevant immune recognition of tumors causing malignant effusions.

M3 - SCORING: Zeitschriftenaufsatz

VL - 29

SP - 93

EP - 104

JO - TUMOR BIOL

JF - TUMOR BIOL

SN - 1010-4283

IS - 2

M1 - 2

ER -