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The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers

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The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers. / Kaiser, Mathias; Burek, Malgorzata; Britz, Stefan; Lankamp, Frauke; Ketelhut, Steffi; Kemper, Björn; Förster, Carola; Gorzelanny, Christian; Goycoolea, Francisco M.

In: INT J MOL SCI, Vol. 20, No. 1, 30.12.2018.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kaiser, M, Burek, M, Britz, S, Lankamp, F, Ketelhut, S, Kemper, B, Förster, C, Gorzelanny, C & Goycoolea, FM 2018, 'The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers', INT J MOL SCI, vol. 20, no. 1. https://doi.org/10.3390/ijms20010122

APA

Kaiser, M., Burek, M., Britz, S., Lankamp, F., Ketelhut, S., Kemper, B., Förster, C., Gorzelanny, C., & Goycoolea, F. M. (2018). The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers. INT J MOL SCI, 20(1). https://doi.org/10.3390/ijms20010122

Vancouver

Kaiser M, Burek M, Britz S, Lankamp F, Ketelhut S, Kemper B et al. The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers. INT J MOL SCI. 2018 Dec 30;20(1). https://doi.org/10.3390/ijms20010122

Bibtex

@article{372f1286521248dca28dcf15bb9b497b,
title = "The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers",
abstract = "Microvascular endothelial cells are an essential part of many biological barriers, such as the blood⁻brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.",
keywords = "Journal Article",
author = "Mathias Kaiser and Malgorzata Burek and Stefan Britz and Frauke Lankamp and Steffi Ketelhut and Bj{\"o}rn Kemper and Carola F{\"o}rster and Christian Gorzelanny and Goycoolea, {Francisco M}",
year = "2018",
month = dec,
day = "30",
doi = "10.3390/ijms20010122",
language = "English",
volume = "20",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "1",

}

RIS

TY - JOUR

T1 - The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers

AU - Kaiser, Mathias

AU - Burek, Malgorzata

AU - Britz, Stefan

AU - Lankamp, Frauke

AU - Ketelhut, Steffi

AU - Kemper, Björn

AU - Förster, Carola

AU - Gorzelanny, Christian

AU - Goycoolea, Francisco M

PY - 2018/12/30

Y1 - 2018/12/30

N2 - Microvascular endothelial cells are an essential part of many biological barriers, such as the blood⁻brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.

AB - Microvascular endothelial cells are an essential part of many biological barriers, such as the blood⁻brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.

KW - Journal Article

U2 - 10.3390/ijms20010122

DO - 10.3390/ijms20010122

M3 - SCORING: Journal article

C2 - 30598013

VL - 20

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 1

ER -