The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
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The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers. / Kaiser, Mathias; Burek, Malgorzata; Britz, Stefan; Lankamp, Frauke; Ketelhut, Steffi; Kemper, Björn; Förster, Carola; Gorzelanny, Christian; Goycoolea, Francisco M.
in: INT J MOL SCI, Jahrgang 20, Nr. 1, 30.12.2018.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The Influence of Capsaicin on the Integrity of Microvascular Endothelial Cell Monolayers
AU - Kaiser, Mathias
AU - Burek, Malgorzata
AU - Britz, Stefan
AU - Lankamp, Frauke
AU - Ketelhut, Steffi
AU - Kemper, Björn
AU - Förster, Carola
AU - Gorzelanny, Christian
AU - Goycoolea, Francisco M
PY - 2018/12/30
Y1 - 2018/12/30
N2 - Microvascular endothelial cells are an essential part of many biological barriers, such as the blood⁻brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.
AB - Microvascular endothelial cells are an essential part of many biological barriers, such as the blood⁻brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.
KW - Journal Article
U2 - 10.3390/ijms20010122
DO - 10.3390/ijms20010122
M3 - SCORING: Journal article
C2 - 30598013
VL - 20
JO - INT J MOL SCI
JF - INT J MOL SCI
SN - 1661-6596
IS - 1
ER -