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The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals

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The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. / Addo, M M; Altfeld, M; Rosenberg, Eric S.; Eldridge, Robert L; Philips, Mary N.; Habeeb, Kathleen; Khatri, Ashok; Brander, Christian; Robbins, Gregory K.; Mazzara, Gail P.; Goulder, Phillip J; Walker, Bruce D.; HIV Controller Study Collaboration.

In: P NATL ACAD SCI USA, Vol. 98, No. 4, 13.02.2001, p. 1781-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Addo, MM, Altfeld, M, Rosenberg, ES, Eldridge, RL, Philips, MN, Habeeb, K, Khatri, A, Brander, C, Robbins, GK, Mazzara, GP, Goulder, PJ, Walker, BD & HIV Controller Study Collaboration 2001, 'The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals', P NATL ACAD SCI USA, vol. 98, no. 4, pp. 1781-6. https://doi.org/10.1073/pnas.98.4.1781

APA

Addo, M. M., Altfeld, M., Rosenberg, E. S., Eldridge, R. L., Philips, M. N., Habeeb, K., Khatri, A., Brander, C., Robbins, G. K., Mazzara, G. P., Goulder, P. J., Walker, B. D., & HIV Controller Study Collaboration (2001). The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. P NATL ACAD SCI USA, 98(4), 1781-6. https://doi.org/10.1073/pnas.98.4.1781

Vancouver

Addo MM, Altfeld M, Rosenberg ES, Eldridge RL, Philips MN, Habeeb K et al. The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals. P NATL ACAD SCI USA. 2001 Feb 13;98(4):1781-6. https://doi.org/10.1073/pnas.98.4.1781

Bibtex

@article{87ceb2c85aaf48b8a09730042fbe8fd2,
title = "The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals",
abstract = "The HIV-1 regulatory proteins Rev and Tat are expressed early in the virus life cycle and thus may be important targets for the immune control of HIV-1-infection and for effective vaccines. However, the extent to which these proteins are targeted in natural HIV-1 infection as well as precise epitopes targeted by human cytotoxic T lymphocytes (CTL) remain to be defined. In the present study, 57 HIV-1-infected individuals were screened for responses against Tat and Rev by using overlapping peptides spanning the entire Tat and Rev proteins. CD8+ T cell responses against Tat and Rev were found in up to 19 and 37% of HIV-1-infected individuals, respectively, indicating that these regulatory proteins are important targets for HIV-1-specific CTL. Despite the small size of these proteins, multiple CTL epitopes were identified in each. These data indicate that Tat and Rev are frequently targeted by CTL in natural HIV-1 infection and may be important targets for HIV vaccines.",
keywords = "CD8-Positive T-Lymphocytes/immunology, Epitopes, T-Lymphocyte/immunology, Gene Products, rev/immunology, Gene Products, tat/immunology, HIV Infections/blood, HIV-1/immunology, Humans, Longitudinal Studies, Peptides/immunology, T-Lymphocytes, Cytotoxic/immunology, rev Gene Products, Human Immunodeficiency Virus, tat Gene Products, Human Immunodeficiency Virus",
author = "Addo, {M M} and M Altfeld and Rosenberg, {Eric S.} and Eldridge, {Robert L} and Philips, {Mary N.} and Kathleen Habeeb and Ashok Khatri and Christian Brander and Robbins, {Gregory K.} and Mazzara, {Gail P.} and Goulder, {Phillip J} and Walker, {Bruce D.} and {HIV Controller Study Collaboration}",
year = "2001",
month = feb,
day = "13",
doi = "10.1073/pnas.98.4.1781",
language = "English",
volume = "98",
pages = "1781--6",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "4",

}

RIS

TY - JOUR

T1 - The HIV-1 regulatory proteins Tat and Rev are frequently targeted by cytotoxic T lymphocytes derived from HIV-1-infected individuals

AU - Addo, M M

AU - Altfeld, M

AU - Rosenberg, Eric S.

AU - Eldridge, Robert L

AU - Philips, Mary N.

AU - Habeeb, Kathleen

AU - Khatri, Ashok

AU - Brander, Christian

AU - Robbins, Gregory K.

AU - Mazzara, Gail P.

AU - Goulder, Phillip J

AU - Walker, Bruce D.

AU - HIV Controller Study Collaboration

PY - 2001/2/13

Y1 - 2001/2/13

N2 - The HIV-1 regulatory proteins Rev and Tat are expressed early in the virus life cycle and thus may be important targets for the immune control of HIV-1-infection and for effective vaccines. However, the extent to which these proteins are targeted in natural HIV-1 infection as well as precise epitopes targeted by human cytotoxic T lymphocytes (CTL) remain to be defined. In the present study, 57 HIV-1-infected individuals were screened for responses against Tat and Rev by using overlapping peptides spanning the entire Tat and Rev proteins. CD8+ T cell responses against Tat and Rev were found in up to 19 and 37% of HIV-1-infected individuals, respectively, indicating that these regulatory proteins are important targets for HIV-1-specific CTL. Despite the small size of these proteins, multiple CTL epitopes were identified in each. These data indicate that Tat and Rev are frequently targeted by CTL in natural HIV-1 infection and may be important targets for HIV vaccines.

AB - The HIV-1 regulatory proteins Rev and Tat are expressed early in the virus life cycle and thus may be important targets for the immune control of HIV-1-infection and for effective vaccines. However, the extent to which these proteins are targeted in natural HIV-1 infection as well as precise epitopes targeted by human cytotoxic T lymphocytes (CTL) remain to be defined. In the present study, 57 HIV-1-infected individuals were screened for responses against Tat and Rev by using overlapping peptides spanning the entire Tat and Rev proteins. CD8+ T cell responses against Tat and Rev were found in up to 19 and 37% of HIV-1-infected individuals, respectively, indicating that these regulatory proteins are important targets for HIV-1-specific CTL. Despite the small size of these proteins, multiple CTL epitopes were identified in each. These data indicate that Tat and Rev are frequently targeted by CTL in natural HIV-1 infection and may be important targets for HIV vaccines.

KW - CD8-Positive T-Lymphocytes/immunology

KW - Epitopes, T-Lymphocyte/immunology

KW - Gene Products, rev/immunology

KW - Gene Products, tat/immunology

KW - HIV Infections/blood

KW - HIV-1/immunology

KW - Humans

KW - Longitudinal Studies

KW - Peptides/immunology

KW - T-Lymphocytes, Cytotoxic/immunology

KW - rev Gene Products, Human Immunodeficiency Virus

KW - tat Gene Products, Human Immunodeficiency Virus

U2 - 10.1073/pnas.98.4.1781

DO - 10.1073/pnas.98.4.1781

M3 - SCORING: Journal article

C2 - 11172028

VL - 98

SP - 1781

EP - 1786

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 4

ER -