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The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan

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The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan. / Fjell, Anders Martin; Grydeland, Hakon; Wang, Yunpeng; Amlien, Inge K; Bartres-Faz, David; Brandmaier, Andreas M; Düzel, Sandra; Elman, Jeremy; Franz, Carol E; Håberg, Asta K; Kietzmann, Tim C; Kievit, Rogier Andrew; Kremen, William S; Krogsrud, Stine K; Kühn, Simone; Lindenberger, Ulman; Macía, Didac; Mowinckel, Athanasia Monika; Nyberg, Lars; Panizzon, Matthew S; Solé-Padullés, Cristina; Sørensen, Øystein; Westerhausen, Rene; Walhovd, Kristine Beate.

In: ELIFE, Vol. 10, e66466, 28.06.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fjell, AM, Grydeland, H, Wang, Y, Amlien, IK, Bartres-Faz, D, Brandmaier, AM, Düzel, S, Elman, J, Franz, CE, Håberg, AK, Kietzmann, TC, Kievit, RA, Kremen, WS, Krogsrud, SK, Kühn, S, Lindenberger, U, Macía, D, Mowinckel, AM, Nyberg, L, Panizzon, MS, Solé-Padullés, C, Sørensen, Ø, Westerhausen, R & Walhovd, KB 2021, 'The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan', ELIFE, vol. 10, e66466. https://doi.org/10.7554/eLife.66466

APA

Fjell, A. M., Grydeland, H., Wang, Y., Amlien, I. K., Bartres-Faz, D., Brandmaier, A. M., Düzel, S., Elman, J., Franz, C. E., Håberg, A. K., Kietzmann, T. C., Kievit, R. A., Kremen, W. S., Krogsrud, S. K., Kühn, S., Lindenberger, U., Macía, D., Mowinckel, A. M., Nyberg, L., ... Walhovd, K. B. (2021). The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan. ELIFE, 10, [e66466]. https://doi.org/10.7554/eLife.66466

Vancouver

Fjell AM, Grydeland H, Wang Y, Amlien IK, Bartres-Faz D, Brandmaier AM et al. The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan. ELIFE. 2021 Jun 28;10. e66466. https://doi.org/10.7554/eLife.66466

Bibtex

@article{0d6c670453bc437d86df13ba7543d6e6,
title = "The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan",
abstract = "Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Cerebral Cortex/growth & development, Child, Child, Preschool, Female, Humans, Longevity, Magnetic Resonance Imaging, Male, Middle Aged, Young Adult",
author = "Fjell, {Anders Martin} and Hakon Grydeland and Yunpeng Wang and Amlien, {Inge K} and David Bartres-Faz and Brandmaier, {Andreas M} and Sandra D{\"u}zel and Jeremy Elman and Franz, {Carol E} and H{\aa}berg, {Asta K} and Kietzmann, {Tim C} and Kievit, {Rogier Andrew} and Kremen, {William S} and Krogsrud, {Stine K} and Simone K{\"u}hn and Ulman Lindenberger and Didac Mac{\'i}a and Mowinckel, {Athanasia Monika} and Lars Nyberg and Panizzon, {Matthew S} and Cristina Sol{\'e}-Padull{\'e}s and {\O}ystein S{\o}rensen and Rene Westerhausen and Walhovd, {Kristine Beate}",
note = "{\textcopyright} 2021, Fjell et al.",
year = "2021",
month = jun,
day = "28",
doi = "10.7554/eLife.66466",
language = "English",
volume = "10",
journal = "ELIFE",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan

AU - Fjell, Anders Martin

AU - Grydeland, Hakon

AU - Wang, Yunpeng

AU - Amlien, Inge K

AU - Bartres-Faz, David

AU - Brandmaier, Andreas M

AU - Düzel, Sandra

AU - Elman, Jeremy

AU - Franz, Carol E

AU - Håberg, Asta K

AU - Kietzmann, Tim C

AU - Kievit, Rogier Andrew

AU - Kremen, William S

AU - Krogsrud, Stine K

AU - Kühn, Simone

AU - Lindenberger, Ulman

AU - Macía, Didac

AU - Mowinckel, Athanasia Monika

AU - Nyberg, Lars

AU - Panizzon, Matthew S

AU - Solé-Padullés, Cristina

AU - Sørensen, Øystein

AU - Westerhausen, Rene

AU - Walhovd, Kristine Beate

N1 - © 2021, Fjell et al.

PY - 2021/6/28

Y1 - 2021/6/28

N2 - Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.

AB - Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Cerebral Cortex/growth & development

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Longevity

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Young Adult

U2 - 10.7554/eLife.66466

DO - 10.7554/eLife.66466

M3 - SCORING: Journal article

C2 - 34180395

VL - 10

JO - ELIFE

JF - ELIFE

SN - 2050-084X

M1 - e66466

ER -