The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan
Standard
The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan. / Fjell, Anders Martin; Grydeland, Hakon; Wang, Yunpeng; Amlien, Inge K; Bartres-Faz, David; Brandmaier, Andreas M; Düzel, Sandra; Elman, Jeremy; Franz, Carol E; Håberg, Asta K; Kietzmann, Tim C; Kievit, Rogier Andrew; Kremen, William S; Krogsrud, Stine K; Kühn, Simone; Lindenberger, Ulman; Macía, Didac; Mowinckel, Athanasia Monika; Nyberg, Lars; Panizzon, Matthew S; Solé-Padullés, Cristina; Sørensen, Øystein; Westerhausen, Rene; Walhovd, Kristine Beate.
in: ELIFE, Jahrgang 10, e66466, 28.06.2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan
AU - Fjell, Anders Martin
AU - Grydeland, Hakon
AU - Wang, Yunpeng
AU - Amlien, Inge K
AU - Bartres-Faz, David
AU - Brandmaier, Andreas M
AU - Düzel, Sandra
AU - Elman, Jeremy
AU - Franz, Carol E
AU - Håberg, Asta K
AU - Kietzmann, Tim C
AU - Kievit, Rogier Andrew
AU - Kremen, William S
AU - Krogsrud, Stine K
AU - Kühn, Simone
AU - Lindenberger, Ulman
AU - Macía, Didac
AU - Mowinckel, Athanasia Monika
AU - Nyberg, Lars
AU - Panizzon, Matthew S
AU - Solé-Padullés, Cristina
AU - Sørensen, Øystein
AU - Westerhausen, Rene
AU - Walhovd, Kristine Beate
N1 - © 2021, Fjell et al.
PY - 2021/6/28
Y1 - 2021/6/28
N2 - Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.
AB - Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Cerebral Cortex/growth & development
KW - Child
KW - Child, Preschool
KW - Female
KW - Humans
KW - Longevity
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Young Adult
U2 - 10.7554/eLife.66466
DO - 10.7554/eLife.66466
M3 - SCORING: Journal article
C2 - 34180395
VL - 10
JO - ELIFE
JF - ELIFE
SN - 2050-084X
M1 - e66466
ER -