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The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB

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The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB. / Barnard, S; Ainsbury, E A; Al-hafidh, J; Hadjidekova, V; Hristova, R; Lindholm, C; Monteiro Gil, O; Moquet, J; Moreno, M; Rößler, U; Thierens, H; Vandevoorde, C; Vral, A; Wojewódzka, M; Rothkamm, K.

In: RADIAT PROT DOSIM, Vol. 164, No. 3, 01.04.2015, p. 265-70.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Barnard, S, Ainsbury, EA, Al-hafidh, J, Hadjidekova, V, Hristova, R, Lindholm, C, Monteiro Gil, O, Moquet, J, Moreno, M, Rößler, U, Thierens, H, Vandevoorde, C, Vral, A, Wojewódzka, M & Rothkamm, K 2015, 'The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB', RADIAT PROT DOSIM, vol. 164, no. 3, pp. 265-70. https://doi.org/10.1093/rpd/ncu259

APA

Barnard, S., Ainsbury, E. A., Al-hafidh, J., Hadjidekova, V., Hristova, R., Lindholm, C., Monteiro Gil, O., Moquet, J., Moreno, M., Rößler, U., Thierens, H., Vandevoorde, C., Vral, A., Wojewódzka, M., & Rothkamm, K. (2015). The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB. RADIAT PROT DOSIM, 164(3), 265-70. https://doi.org/10.1093/rpd/ncu259

Vancouver

Barnard S, Ainsbury EA, Al-hafidh J, Hadjidekova V, Hristova R, Lindholm C et al. The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB. RADIAT PROT DOSIM. 2015 Apr 1;164(3):265-70. https://doi.org/10.1093/rpd/ncu259

Bibtex

@article{5013d91d164f45309f51ad00b2457f24,
title = "The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB",
abstract = "In the event of a mass casualty radiation incident, the gamma-H2AX foci assay could be a useful tool to estimate radiation doses received by individuals. The rapid processing time of blood samples of just a few hours and the potential for batch processing, enabling high throughput, make the assay ideal for early triage categorisation to separate the 'worried well' from the low and critically exposed by quantifying radiation-induced foci in peripheral blood lymphocytes. Within the RENEB framework, 8 European laboratories have taken part in the first European gamma-H2AX biodosimetry exercise, which consisted of a telescoring comparison of 200 circulated foci images taken from 8 samples, and a comparison of 10 fresh blood lymphocyte samples that were shipped overnight to participating labs 4 or 24 h post-exposure. Despite large variations between laboratories in the dose-response relationship for foci induction, the obtained results indicate that the network should be able to use the gamma-H2AX assay for rapidly identifying the most severely exposed individuals within a cohort who could then be prioritised for accurate chromosome dosimetry.",
author = "S Barnard and Ainsbury, {E A} and J Al-hafidh and V Hadjidekova and R Hristova and C Lindholm and {Monteiro Gil}, O and J Moquet and M Moreno and U R{\"o}{\ss}ler and H Thierens and C Vandevoorde and A Vral and M Wojew{\'o}dzka and K Rothkamm",
note = "{\textcopyright} Crown copyright 2014.",
year = "2015",
month = apr,
day = "1",
doi = "10.1093/rpd/ncu259",
language = "English",
volume = "164",
pages = "265--70",
journal = "RADIAT PROT DOSIM",
issn = "0144-8420",
publisher = "Oxford University Press",
number = "3",

}

RIS

TY - JOUR

T1 - The first gamma-H2AX biodosimetry intercomparison exercise of the developing European biodosimetry network RENEB

AU - Barnard, S

AU - Ainsbury, E A

AU - Al-hafidh, J

AU - Hadjidekova, V

AU - Hristova, R

AU - Lindholm, C

AU - Monteiro Gil, O

AU - Moquet, J

AU - Moreno, M

AU - Rößler, U

AU - Thierens, H

AU - Vandevoorde, C

AU - Vral, A

AU - Wojewódzka, M

AU - Rothkamm, K

N1 - © Crown copyright 2014.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - In the event of a mass casualty radiation incident, the gamma-H2AX foci assay could be a useful tool to estimate radiation doses received by individuals. The rapid processing time of blood samples of just a few hours and the potential for batch processing, enabling high throughput, make the assay ideal for early triage categorisation to separate the 'worried well' from the low and critically exposed by quantifying radiation-induced foci in peripheral blood lymphocytes. Within the RENEB framework, 8 European laboratories have taken part in the first European gamma-H2AX biodosimetry exercise, which consisted of a telescoring comparison of 200 circulated foci images taken from 8 samples, and a comparison of 10 fresh blood lymphocyte samples that were shipped overnight to participating labs 4 or 24 h post-exposure. Despite large variations between laboratories in the dose-response relationship for foci induction, the obtained results indicate that the network should be able to use the gamma-H2AX assay for rapidly identifying the most severely exposed individuals within a cohort who could then be prioritised for accurate chromosome dosimetry.

AB - In the event of a mass casualty radiation incident, the gamma-H2AX foci assay could be a useful tool to estimate radiation doses received by individuals. The rapid processing time of blood samples of just a few hours and the potential for batch processing, enabling high throughput, make the assay ideal for early triage categorisation to separate the 'worried well' from the low and critically exposed by quantifying radiation-induced foci in peripheral blood lymphocytes. Within the RENEB framework, 8 European laboratories have taken part in the first European gamma-H2AX biodosimetry exercise, which consisted of a telescoring comparison of 200 circulated foci images taken from 8 samples, and a comparison of 10 fresh blood lymphocyte samples that were shipped overnight to participating labs 4 or 24 h post-exposure. Despite large variations between laboratories in the dose-response relationship for foci induction, the obtained results indicate that the network should be able to use the gamma-H2AX assay for rapidly identifying the most severely exposed individuals within a cohort who could then be prioritised for accurate chromosome dosimetry.

U2 - 10.1093/rpd/ncu259

DO - 10.1093/rpd/ncu259

M3 - SCORING: Journal article

C2 - 25118318

VL - 164

SP - 265

EP - 270

JO - RADIAT PROT DOSIM

JF - RADIAT PROT DOSIM

SN - 0144-8420

IS - 3

ER -