The Evolving Complexity of the Podocyte Cytoskeleton

Christoph Schell; Tobias B Huber

doi:10.1681/ASN.2017020143

The Evolving Complexity of the Podocyte Cytoskeleton

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The Evolving Complexity of the Podocyte Cytoskeleton. / Schell, Christoph; Huber, Tobias B.

In: J AM SOC NEPHROL, Vol. 28, No. 11, 11.2017, p. 3166-3174.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Schell, C & Huber, TB 2017, 'The Evolving Complexity of the Podocyte Cytoskeleton', J AM SOC NEPHROL, vol. 28, no. 11, pp. 3166-3174. https://doi.org/10.1681/ASN.2017020143

APA

Schell, C., & Huber, T. B. (2017). The Evolving Complexity of the Podocyte Cytoskeleton. J AM SOC NEPHROL, 28(11), 3166-3174. https://doi.org/10.1681/ASN.2017020143

Vancouver

Schell C, Huber TB. The Evolving Complexity of the Podocyte Cytoskeleton. J AM SOC NEPHROL. 2017 Nov;28(11):3166-3174. https://doi.org/10.1681/ASN.2017020143

Bibtex

@article{4bdf861e850644d3b339c4b569b66329,

title = "The Evolving Complexity of the Podocyte Cytoskeleton",

abstract = "Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease. Moreover, mechanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this subcellular structure could be targeted for therapeutic purposes. This review summarizes our current understanding of the function of the cytoskeleton in podocytes and the associated implications for pathophysiology.",

keywords = "Journal Article",

author = "Christoph Schell and Huber, {Tobias B}",

note = "Copyright {\textcopyright} 2017 by the American Society of Nephrology.",

year = "2017",

month = nov,

doi = "10.1681/ASN.2017020143",

language = "English",

volume = "28",

pages = "3166--3174",

journal = "J AM SOC NEPHROL",

issn = "1046-6673",

publisher = "American Society of Nephrology",

number = "11",

}

RIS

TY - JOUR

T1 - The Evolving Complexity of the Podocyte Cytoskeleton

AU - Schell, Christoph

AU - Huber, Tobias B

PY - 2017/11

Y1 - 2017/11

N2 - Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease. Moreover, mechanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this subcellular structure could be targeted for therapeutic purposes. This review summarizes our current understanding of the function of the cytoskeleton in podocytes and the associated implications for pathophysiology.

AB - Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease. Moreover, mechanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this subcellular structure could be targeted for therapeutic purposes. This review summarizes our current understanding of the function of the cytoskeleton in podocytes and the associated implications for pathophysiology.

KW - Journal Article

U2 - 10.1681/ASN.2017020143

DO - 10.1681/ASN.2017020143

M3 - SCORING: Review article

C2 - 28864466

VL - 28

SP - 3166

EP - 3174

JO - J AM SOC NEPHROL

JF - J AM SOC NEPHROL

SN - 1046-6673

IS - 11

ER -