The Evolving Complexity of the Podocyte Cytoskeleton
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The Evolving Complexity of the Podocyte Cytoskeleton. / Schell, Christoph; Huber, Tobias B.
in: J AM SOC NEPHROL, Jahrgang 28, Nr. 11, 11.2017, S. 3166-3174.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - The Evolving Complexity of the Podocyte Cytoskeleton
AU - Schell, Christoph
AU - Huber, Tobias B
N1 - Copyright © 2017 by the American Society of Nephrology.
PY - 2017/11
Y1 - 2017/11
N2 - Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease. Moreover, mechanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this subcellular structure could be targeted for therapeutic purposes. This review summarizes our current understanding of the function of the cytoskeleton in podocytes and the associated implications for pathophysiology.
AB - Podocytes exhibit a unique cytoskeletal architecture that is fundamentally linked to their function in maintaining the kidney filtration barrier. The cytoskeleton regulates podocyte shape, structure, stability, slit diaphragm insertion, adhesion, plasticity, and dynamic response to environmental stimuli. Genetic mutations demonstrate that even slight impairment of the podocyte cytoskeletal apparatus results in proteinuria and glomerular disease. Moreover, mechanisms underpinning all acquired glomerular pathologies converge on disruption of the cytoskeleton, suggesting that this subcellular structure could be targeted for therapeutic purposes. This review summarizes our current understanding of the function of the cytoskeleton in podocytes and the associated implications for pathophysiology.
KW - Journal Article
U2 - 10.1681/ASN.2017020143
DO - 10.1681/ASN.2017020143
M3 - SCORING: Review article
C2 - 28864466
VL - 28
SP - 3166
EP - 3174
JO - J AM SOC NEPHROL
JF - J AM SOC NEPHROL
SN - 1046-6673
IS - 11
ER -