The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger
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The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger. / Wismar, J; Löffler, T; Habtemichael, N; Vef, O; Geissen, M; Zirwes, R; Altmeyer, W; Sass, H; Gateff, E.
In: MECH DEVELOP, Vol. 53, No. 1, 09.1995, p. 141-154.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger
AU - Wismar, J
AU - Löffler, T
AU - Habtemichael, N
AU - Vef, O
AU - Geissen, M
AU - Zirwes, R
AU - Altmeyer, W
AU - Sass, H
AU - Gateff, E
PY - 1995/9
Y1 - 1995/9
N2 - The lethal(3)malignant brain tumor [t(3)mbt] gene causes, when mutated, malignant growth of the adult optic neuroblasts and ganglion mother cells in the larval brain and imaginal disc overgrowth. Via overlapping deficiencies a genomic region of approximately 6.0 kb was identified, containing l(3)mbt+ gene sequences. The l(3)mbt+ gene encodes seven transcripts of 5.8 kb, 5.65 kb, 5.35 kb, 5.25 kb, 5.0 kb, 4.4 kb and 1.8 kb. The putative MBT163 protein, encompassing 1477 amino acids, is proline-rich and contains a novel zinc finger. In situ hybridizations of whole mount embryos and larval tissues revealed l(3)mbt+ RNA ubiquitously present in stage 1 embryos and throughout embryonic development in most tissues. In third instar larvae l(3)mbt+ RNA is detected in the adult optic anlagen and the imaginal discs, the tissues directly affected by l(3)mbt mutations, but also in tissues, showing normal development in the mutant, such as the gut, the goblet cells and the hematopoietic organs.
AB - The lethal(3)malignant brain tumor [t(3)mbt] gene causes, when mutated, malignant growth of the adult optic neuroblasts and ganglion mother cells in the larval brain and imaginal disc overgrowth. Via overlapping deficiencies a genomic region of approximately 6.0 kb was identified, containing l(3)mbt+ gene sequences. The l(3)mbt+ gene encodes seven transcripts of 5.8 kb, 5.65 kb, 5.35 kb, 5.25 kb, 5.0 kb, 4.4 kb and 1.8 kb. The putative MBT163 protein, encompassing 1477 amino acids, is proline-rich and contains a novel zinc finger. In situ hybridizations of whole mount embryos and larval tissues revealed l(3)mbt+ RNA ubiquitously present in stage 1 embryos and throughout embryonic development in most tissues. In third instar larvae l(3)mbt+ RNA is detected in the adult optic anlagen and the imaginal discs, the tissues directly affected by l(3)mbt mutations, but also in tissues, showing normal development in the mutant, such as the gut, the goblet cells and the hematopoietic organs.
KW - Amino Acid Sequence
KW - Animals
KW - Base Sequence
KW - Brain Neoplasms/genetics
KW - Drosophila melanogaster/embryology
KW - Female
KW - Genes, Insect
KW - Genes, Lethal
KW - Genes, Tumor Suppressor
KW - Genetic Code
KW - Genome
KW - Larva/genetics
KW - Male
KW - Molecular Sequence Data
KW - Peptides/genetics
KW - Phenotype
KW - Proline
KW - Proline-Rich Protein Domains
KW - Zinc Fingers
U2 - 10.1016/0925-4773(95)00431-9
DO - 10.1016/0925-4773(95)00431-9
M3 - SCORING: Journal article
C2 - 8555106
VL - 53
SP - 141
EP - 154
JO - MECH DEVELOP
JF - MECH DEVELOP
SN - 0925-4773
IS - 1
ER -