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The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger

Standard

The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger. / Wismar, J; Löffler, T; Habtemichael, N; Vef, O; Geissen, M; Zirwes, R; Altmeyer, W; Sass, H; Gateff, E.

in: MECH DEVELOP, Jahrgang 53, Nr. 1, 09.1995, S. 141-154.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wismar, J, Löffler, T, Habtemichael, N, Vef, O, Geissen, M, Zirwes, R, Altmeyer, W, Sass, H & Gateff, E 1995, 'The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger', MECH DEVELOP, Jg. 53, Nr. 1, S. 141-154. https://doi.org/10.1016/0925-4773(95)00431-9

APA

Wismar, J., Löffler, T., Habtemichael, N., Vef, O., Geissen, M., Zirwes, R., Altmeyer, W., Sass, H., & Gateff, E. (1995). The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger. MECH DEVELOP, 53(1), 141-154. https://doi.org/10.1016/0925-4773(95)00431-9

Vancouver

Wismar J, Löffler T, Habtemichael N, Vef O, Geissen M, Zirwes R et al. The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger. MECH DEVELOP. 1995 Sep;53(1):141-154. https://doi.org/10.1016/0925-4773(95)00431-9

Bibtex

@article{1c28370436ef4680af75eaa25303a261,
title = "The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger",
abstract = "The lethal(3)malignant brain tumor [t(3)mbt] gene causes, when mutated, malignant growth of the adult optic neuroblasts and ganglion mother cells in the larval brain and imaginal disc overgrowth. Via overlapping deficiencies a genomic region of approximately 6.0 kb was identified, containing l(3)mbt+ gene sequences. The l(3)mbt+ gene encodes seven transcripts of 5.8 kb, 5.65 kb, 5.35 kb, 5.25 kb, 5.0 kb, 4.4 kb and 1.8 kb. The putative MBT163 protein, encompassing 1477 amino acids, is proline-rich and contains a novel zinc finger. In situ hybridizations of whole mount embryos and larval tissues revealed l(3)mbt+ RNA ubiquitously present in stage 1 embryos and throughout embryonic development in most tissues. In third instar larvae l(3)mbt+ RNA is detected in the adult optic anlagen and the imaginal discs, the tissues directly affected by l(3)mbt mutations, but also in tissues, showing normal development in the mutant, such as the gut, the goblet cells and the hematopoietic organs.",
keywords = "Amino Acid Sequence, Animals, Base Sequence, Brain Neoplasms/genetics, Drosophila melanogaster/embryology, Female, Genes, Insect, Genes, Lethal, Genes, Tumor Suppressor, Genetic Code, Genome, Larva/genetics, Male, Molecular Sequence Data, Peptides/genetics, Phenotype, Proline, Proline-Rich Protein Domains, Zinc Fingers",
author = "J Wismar and T L{\"o}ffler and N Habtemichael and O Vef and M Geissen and R Zirwes and W Altmeyer and H Sass and E Gateff",
year = "1995",
month = sep,
doi = "10.1016/0925-4773(95)00431-9",
language = "English",
volume = "53",
pages = "141--154",
journal = "MECH DEVELOP",
issn = "0925-4773",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - The Drosophila melanogaster tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger

AU - Wismar, J

AU - Löffler, T

AU - Habtemichael, N

AU - Vef, O

AU - Geissen, M

AU - Zirwes, R

AU - Altmeyer, W

AU - Sass, H

AU - Gateff, E

PY - 1995/9

Y1 - 1995/9

N2 - The lethal(3)malignant brain tumor [t(3)mbt] gene causes, when mutated, malignant growth of the adult optic neuroblasts and ganglion mother cells in the larval brain and imaginal disc overgrowth. Via overlapping deficiencies a genomic region of approximately 6.0 kb was identified, containing l(3)mbt+ gene sequences. The l(3)mbt+ gene encodes seven transcripts of 5.8 kb, 5.65 kb, 5.35 kb, 5.25 kb, 5.0 kb, 4.4 kb and 1.8 kb. The putative MBT163 protein, encompassing 1477 amino acids, is proline-rich and contains a novel zinc finger. In situ hybridizations of whole mount embryos and larval tissues revealed l(3)mbt+ RNA ubiquitously present in stage 1 embryos and throughout embryonic development in most tissues. In third instar larvae l(3)mbt+ RNA is detected in the adult optic anlagen and the imaginal discs, the tissues directly affected by l(3)mbt mutations, but also in tissues, showing normal development in the mutant, such as the gut, the goblet cells and the hematopoietic organs.

AB - The lethal(3)malignant brain tumor [t(3)mbt] gene causes, when mutated, malignant growth of the adult optic neuroblasts and ganglion mother cells in the larval brain and imaginal disc overgrowth. Via overlapping deficiencies a genomic region of approximately 6.0 kb was identified, containing l(3)mbt+ gene sequences. The l(3)mbt+ gene encodes seven transcripts of 5.8 kb, 5.65 kb, 5.35 kb, 5.25 kb, 5.0 kb, 4.4 kb and 1.8 kb. The putative MBT163 protein, encompassing 1477 amino acids, is proline-rich and contains a novel zinc finger. In situ hybridizations of whole mount embryos and larval tissues revealed l(3)mbt+ RNA ubiquitously present in stage 1 embryos and throughout embryonic development in most tissues. In third instar larvae l(3)mbt+ RNA is detected in the adult optic anlagen and the imaginal discs, the tissues directly affected by l(3)mbt mutations, but also in tissues, showing normal development in the mutant, such as the gut, the goblet cells and the hematopoietic organs.

KW - Amino Acid Sequence

KW - Animals

KW - Base Sequence

KW - Brain Neoplasms/genetics

KW - Drosophila melanogaster/embryology

KW - Female

KW - Genes, Insect

KW - Genes, Lethal

KW - Genes, Tumor Suppressor

KW - Genetic Code

KW - Genome

KW - Larva/genetics

KW - Male

KW - Molecular Sequence Data

KW - Peptides/genetics

KW - Phenotype

KW - Proline

KW - Proline-Rich Protein Domains

KW - Zinc Fingers

U2 - 10.1016/0925-4773(95)00431-9

DO - 10.1016/0925-4773(95)00431-9

M3 - SCORING: Journal article

C2 - 8555106

VL - 53

SP - 141

EP - 154

JO - MECH DEVELOP

JF - MECH DEVELOP

SN - 0925-4773

IS - 1

ER -