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The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors

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The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors. / Duong, Chi Vinh; Geissen, Markus; Rohrer, Hermann.

In: DEVELOPMENT, Vol. 129, No. 6, 03.2002, p. 1387-1396.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Duong, CV, Geissen, M & Rohrer, H 2002, 'The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors', DEVELOPMENT, vol. 129, no. 6, pp. 1387-1396.

APA

Duong, C. V., Geissen, M., & Rohrer, H. (2002). The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors. DEVELOPMENT, 129(6), 1387-1396.

Vancouver

Duong CV, Geissen M, Rohrer H. The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors. DEVELOPMENT. 2002 Mar;129(6):1387-1396.

Bibtex

@article{2866372278f34815a0c0e80f2336ac25,
title = "The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors",
abstract = "Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. Cholinergic sympathetic neurons are characterized by the expression of choline acetyl transferase (ChAT), vesicular acetylcholine transporter (VAChT) and the vasoactive intestinal peptide (VIP). To investigate the role of cytokine growth factor family members in the development of cholinergic sympathetic neurons, we interfered in vivo with the function of the subclass of cytokine receptors that contains LIFRbeta as essential receptor subunit. Expression of LIFRbeta antisense RNA interfered with LIFRbeta expression and strongly reduced the developmental induction of VIP expression. By contrast, ganglion size and the number of ChAT-positive cells were not reduced. These results demonstrate a physiological role of cytokines acting through LIFRbeta-containing receptors in the control of VIP expression in sympathetic neurons.",
keywords = "Amino Acid Sequence, Animals, Antigens, CD/metabolism, Carrier Proteins/metabolism, Chick Embryo, Choline/physiology, Choline O-Acetyltransferase/metabolism, Cloning, Molecular, Cytokine Receptor gp130, Cytokines/metabolism, Membrane Glycoproteins/metabolism, Membrane Transport Proteins, Molecular Sequence Data, Receptors, Cytokine/genetics, Receptors, OSM-LIF, Sequence Alignment, Signal Transduction, Sympathetic Nervous System/physiology, Vasoactive Intestinal Peptide/metabolism, Vesicular Acetylcholine Transport Proteins, Vesicular Transport Proteins",
author = "Duong, {Chi Vinh} and Markus Geissen and Hermann Rohrer",
year = "2002",
month = mar,
language = "English",
volume = "129",
pages = "1387--1396",
journal = "DEVELOPMENT",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors

AU - Duong, Chi Vinh

AU - Geissen, Markus

AU - Rohrer, Hermann

PY - 2002/3

Y1 - 2002/3

N2 - Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. Cholinergic sympathetic neurons are characterized by the expression of choline acetyl transferase (ChAT), vesicular acetylcholine transporter (VAChT) and the vasoactive intestinal peptide (VIP). To investigate the role of cytokine growth factor family members in the development of cholinergic sympathetic neurons, we interfered in vivo with the function of the subclass of cytokine receptors that contains LIFRbeta as essential receptor subunit. Expression of LIFRbeta antisense RNA interfered with LIFRbeta expression and strongly reduced the developmental induction of VIP expression. By contrast, ganglion size and the number of ChAT-positive cells were not reduced. These results demonstrate a physiological role of cytokines acting through LIFRbeta-containing receptors in the control of VIP expression in sympathetic neurons.

AB - Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. Cholinergic sympathetic neurons are characterized by the expression of choline acetyl transferase (ChAT), vesicular acetylcholine transporter (VAChT) and the vasoactive intestinal peptide (VIP). To investigate the role of cytokine growth factor family members in the development of cholinergic sympathetic neurons, we interfered in vivo with the function of the subclass of cytokine receptors that contains LIFRbeta as essential receptor subunit. Expression of LIFRbeta antisense RNA interfered with LIFRbeta expression and strongly reduced the developmental induction of VIP expression. By contrast, ganglion size and the number of ChAT-positive cells were not reduced. These results demonstrate a physiological role of cytokines acting through LIFRbeta-containing receptors in the control of VIP expression in sympathetic neurons.

KW - Amino Acid Sequence

KW - Animals

KW - Antigens, CD/metabolism

KW - Carrier Proteins/metabolism

KW - Chick Embryo

KW - Choline/physiology

KW - Choline O-Acetyltransferase/metabolism

KW - Cloning, Molecular

KW - Cytokine Receptor gp130

KW - Cytokines/metabolism

KW - Membrane Glycoproteins/metabolism

KW - Membrane Transport Proteins

KW - Molecular Sequence Data

KW - Receptors, Cytokine/genetics

KW - Receptors, OSM-LIF

KW - Sequence Alignment

KW - Signal Transduction

KW - Sympathetic Nervous System/physiology

KW - Vasoactive Intestinal Peptide/metabolism

KW - Vesicular Acetylcholine Transport Proteins

KW - Vesicular Transport Proteins

M3 - SCORING: Journal article

C2 - 11880348

VL - 129

SP - 1387

EP - 1396

JO - DEVELOPMENT

JF - DEVELOPMENT

SN - 0950-1991

IS - 6

ER -