The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors
Standard
The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors. / Duong, Chi Vinh; Geissen, Markus; Rohrer, Hermann.
in: DEVELOPMENT, Jahrgang 129, Nr. 6, 03.2002, S. 1387-1396.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The developmental expression of vasoactive intestinal peptide (VIP) in cholinergic sympathetic neurons depends on cytokines signaling through LIFRbeta-containing receptors
AU - Duong, Chi Vinh
AU - Geissen, Markus
AU - Rohrer, Hermann
PY - 2002/3
Y1 - 2002/3
N2 - Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. Cholinergic sympathetic neurons are characterized by the expression of choline acetyl transferase (ChAT), vesicular acetylcholine transporter (VAChT) and the vasoactive intestinal peptide (VIP). To investigate the role of cytokine growth factor family members in the development of cholinergic sympathetic neurons, we interfered in vivo with the function of the subclass of cytokine receptors that contains LIFRbeta as essential receptor subunit. Expression of LIFRbeta antisense RNA interfered with LIFRbeta expression and strongly reduced the developmental induction of VIP expression. By contrast, ganglion size and the number of ChAT-positive cells were not reduced. These results demonstrate a physiological role of cytokines acting through LIFRbeta-containing receptors in the control of VIP expression in sympathetic neurons.
AB - Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. Cholinergic sympathetic neurons are characterized by the expression of choline acetyl transferase (ChAT), vesicular acetylcholine transporter (VAChT) and the vasoactive intestinal peptide (VIP). To investigate the role of cytokine growth factor family members in the development of cholinergic sympathetic neurons, we interfered in vivo with the function of the subclass of cytokine receptors that contains LIFRbeta as essential receptor subunit. Expression of LIFRbeta antisense RNA interfered with LIFRbeta expression and strongly reduced the developmental induction of VIP expression. By contrast, ganglion size and the number of ChAT-positive cells were not reduced. These results demonstrate a physiological role of cytokines acting through LIFRbeta-containing receptors in the control of VIP expression in sympathetic neurons.
KW - Amino Acid Sequence
KW - Animals
KW - Antigens, CD/metabolism
KW - Carrier Proteins/metabolism
KW - Chick Embryo
KW - Choline/physiology
KW - Choline O-Acetyltransferase/metabolism
KW - Cloning, Molecular
KW - Cytokine Receptor gp130
KW - Cytokines/metabolism
KW - Membrane Glycoproteins/metabolism
KW - Membrane Transport Proteins
KW - Molecular Sequence Data
KW - Receptors, Cytokine/genetics
KW - Receptors, OSM-LIF
KW - Sequence Alignment
KW - Signal Transduction
KW - Sympathetic Nervous System/physiology
KW - Vasoactive Intestinal Peptide/metabolism
KW - Vesicular Acetylcholine Transport Proteins
KW - Vesicular Transport Proteins
M3 - SCORING: Journal article
C2 - 11880348
VL - 129
SP - 1387
EP - 1396
JO - DEVELOPMENT
JF - DEVELOPMENT
SN - 0950-1991
IS - 6
ER -