The contribution of B cells to renal interstitial inflammation
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The contribution of B cells to renal interstitial inflammation. / Heller, Florian; Lindenmeyer, Maja T; Cohen, Clemens D; Brandt, Ulrike; Draganovici, Dan; Fischereder, Michael; Kretzler, Matthias; Anders, Hans-Joachim; Sitter, Thomas; Mosberger, Isabella; Kerjaschki, Dontscho; Regele, Heinz; Schlöndorff, Detlef; Segerer, Stephan.
In: AM J PATHOL, Vol. 170, No. 2, 02.2007, p. 457-68.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - The contribution of B cells to renal interstitial inflammation
AU - Heller, Florian
AU - Lindenmeyer, Maja T
AU - Cohen, Clemens D
AU - Brandt, Ulrike
AU - Draganovici, Dan
AU - Fischereder, Michael
AU - Kretzler, Matthias
AU - Anders, Hans-Joachim
AU - Sitter, Thomas
AU - Mosberger, Isabella
AU - Kerjaschki, Dontscho
AU - Regele, Heinz
AU - Schlöndorff, Detlef
AU - Segerer, Stephan
PY - 2007/2
Y1 - 2007/2
N2 - Local B-cell infiltrates play a role in tissue fibrosis, neolymphangiogenesis, and renal allograft survival. We sought to characterize the B-cell infiltrates, factors involved in B-cell recruitment, and lymphangiogenesis in renal interstitial injury (ie, acute and chronic interstitial nephritis and chronic IgA nephropathy). CD20-positive B cells formed a prominent part of the interstitial infiltrating cells. Together with CD3-positive T cells, the CD20-positive B cells formed larger nodular structures. CD10-positive pre-B cells were rare, and the majority were mature CD27-positive B cells. Proliferating B cells were detected within nodular infiltrates. The level of mRNA expression of the chemokine CXCL13 was increased and correlated with CD20 mRNA in the tubulointerstitial space. CXCL13 protein was predominantly found at sites of nodular infiltrates, in association with CXCR5-positive B cells. Furthermore, sites of chronic interstitial inflammation were associated with a high number of lymphatic vessels. B-cell infiltrates form a prominent part of the interstitial infiltrates both in primary interstitial lesions and in IgA nephropathy. CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system.
AB - Local B-cell infiltrates play a role in tissue fibrosis, neolymphangiogenesis, and renal allograft survival. We sought to characterize the B-cell infiltrates, factors involved in B-cell recruitment, and lymphangiogenesis in renal interstitial injury (ie, acute and chronic interstitial nephritis and chronic IgA nephropathy). CD20-positive B cells formed a prominent part of the interstitial infiltrating cells. Together with CD3-positive T cells, the CD20-positive B cells formed larger nodular structures. CD10-positive pre-B cells were rare, and the majority were mature CD27-positive B cells. Proliferating B cells were detected within nodular infiltrates. The level of mRNA expression of the chemokine CXCL13 was increased and correlated with CD20 mRNA in the tubulointerstitial space. CXCL13 protein was predominantly found at sites of nodular infiltrates, in association with CXCR5-positive B cells. Furthermore, sites of chronic interstitial inflammation were associated with a high number of lymphatic vessels. B-cell infiltrates form a prominent part of the interstitial infiltrates both in primary interstitial lesions and in IgA nephropathy. CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system.
KW - Acute Disease
KW - Adolescent
KW - Adult
KW - Aged
KW - Antigens, CD
KW - B-Lymphocytes
KW - Chemokine CXCL13
KW - Chemokines, CXC
KW - Child
KW - Chronic Disease
KW - Female
KW - Glomerulonephritis, IGA
KW - Humans
KW - Lymphatic Vessels
KW - Male
KW - Middle Aged
KW - Nephritis, Interstitial
KW - Receptors, CXCR5
KW - Receptors, Chemokine
KW - T-Lymphocytes
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.2353/ajpath.2007.060554
DO - 10.2353/ajpath.2007.060554
M3 - SCORING: Journal article
C2 - 17255314
VL - 170
SP - 457
EP - 468
JO - AM J PATHOL
JF - AM J PATHOL
SN - 0002-9440
IS - 2
ER -