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The contribution of B cells to renal interstitial inflammation

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The contribution of B cells to renal interstitial inflammation. / Heller, Florian; Lindenmeyer, Maja T; Cohen, Clemens D; Brandt, Ulrike; Draganovici, Dan; Fischereder, Michael; Kretzler, Matthias; Anders, Hans-Joachim; Sitter, Thomas; Mosberger, Isabella; Kerjaschki, Dontscho; Regele, Heinz; Schlöndorff, Detlef; Segerer, Stephan.

in: AM J PATHOL, Jahrgang 170, Nr. 2, 02.2007, S. 457-68.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Heller, F, Lindenmeyer, MT, Cohen, CD, Brandt, U, Draganovici, D, Fischereder, M, Kretzler, M, Anders, H-J, Sitter, T, Mosberger, I, Kerjaschki, D, Regele, H, Schlöndorff, D & Segerer, S 2007, 'The contribution of B cells to renal interstitial inflammation', AM J PATHOL, Jg. 170, Nr. 2, S. 457-68. https://doi.org/10.2353/ajpath.2007.060554

APA

Heller, F., Lindenmeyer, M. T., Cohen, C. D., Brandt, U., Draganovici, D., Fischereder, M., Kretzler, M., Anders, H-J., Sitter, T., Mosberger, I., Kerjaschki, D., Regele, H., Schlöndorff, D., & Segerer, S. (2007). The contribution of B cells to renal interstitial inflammation. AM J PATHOL, 170(2), 457-68. https://doi.org/10.2353/ajpath.2007.060554

Vancouver

Heller F, Lindenmeyer MT, Cohen CD, Brandt U, Draganovici D, Fischereder M et al. The contribution of B cells to renal interstitial inflammation. AM J PATHOL. 2007 Feb;170(2):457-68. https://doi.org/10.2353/ajpath.2007.060554

Bibtex

@article{56cabfb686f64e6eb97c9f17f447d025,
title = "The contribution of B cells to renal interstitial inflammation",
abstract = "Local B-cell infiltrates play a role in tissue fibrosis, neolymphangiogenesis, and renal allograft survival. We sought to characterize the B-cell infiltrates, factors involved in B-cell recruitment, and lymphangiogenesis in renal interstitial injury (ie, acute and chronic interstitial nephritis and chronic IgA nephropathy). CD20-positive B cells formed a prominent part of the interstitial infiltrating cells. Together with CD3-positive T cells, the CD20-positive B cells formed larger nodular structures. CD10-positive pre-B cells were rare, and the majority were mature CD27-positive B cells. Proliferating B cells were detected within nodular infiltrates. The level of mRNA expression of the chemokine CXCL13 was increased and correlated with CD20 mRNA in the tubulointerstitial space. CXCL13 protein was predominantly found at sites of nodular infiltrates, in association with CXCR5-positive B cells. Furthermore, sites of chronic interstitial inflammation were associated with a high number of lymphatic vessels. B-cell infiltrates form a prominent part of the interstitial infiltrates both in primary interstitial lesions and in IgA nephropathy. CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system.",
keywords = "Acute Disease, Adolescent, Adult, Aged, Antigens, CD, B-Lymphocytes, Chemokine CXCL13, Chemokines, CXC, Child, Chronic Disease, Female, Glomerulonephritis, IGA, Humans, Lymphatic Vessels, Male, Middle Aged, Nephritis, Interstitial, Receptors, CXCR5, Receptors, Chemokine, T-Lymphocytes, Journal Article, Research Support, Non-U.S. Gov't",
author = "Florian Heller and Lindenmeyer, {Maja T} and Cohen, {Clemens D} and Ulrike Brandt and Dan Draganovici and Michael Fischereder and Matthias Kretzler and Hans-Joachim Anders and Thomas Sitter and Isabella Mosberger and Dontscho Kerjaschki and Heinz Regele and Detlef Schl{\"o}ndorff and Stephan Segerer",
year = "2007",
month = feb,
doi = "10.2353/ajpath.2007.060554",
language = "English",
volume = "170",
pages = "457--68",
journal = "AM J PATHOL",
issn = "0002-9440",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - The contribution of B cells to renal interstitial inflammation

AU - Heller, Florian

AU - Lindenmeyer, Maja T

AU - Cohen, Clemens D

AU - Brandt, Ulrike

AU - Draganovici, Dan

AU - Fischereder, Michael

AU - Kretzler, Matthias

AU - Anders, Hans-Joachim

AU - Sitter, Thomas

AU - Mosberger, Isabella

AU - Kerjaschki, Dontscho

AU - Regele, Heinz

AU - Schlöndorff, Detlef

AU - Segerer, Stephan

PY - 2007/2

Y1 - 2007/2

N2 - Local B-cell infiltrates play a role in tissue fibrosis, neolymphangiogenesis, and renal allograft survival. We sought to characterize the B-cell infiltrates, factors involved in B-cell recruitment, and lymphangiogenesis in renal interstitial injury (ie, acute and chronic interstitial nephritis and chronic IgA nephropathy). CD20-positive B cells formed a prominent part of the interstitial infiltrating cells. Together with CD3-positive T cells, the CD20-positive B cells formed larger nodular structures. CD10-positive pre-B cells were rare, and the majority were mature CD27-positive B cells. Proliferating B cells were detected within nodular infiltrates. The level of mRNA expression of the chemokine CXCL13 was increased and correlated with CD20 mRNA in the tubulointerstitial space. CXCL13 protein was predominantly found at sites of nodular infiltrates, in association with CXCR5-positive B cells. Furthermore, sites of chronic interstitial inflammation were associated with a high number of lymphatic vessels. B-cell infiltrates form a prominent part of the interstitial infiltrates both in primary interstitial lesions and in IgA nephropathy. CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system.

AB - Local B-cell infiltrates play a role in tissue fibrosis, neolymphangiogenesis, and renal allograft survival. We sought to characterize the B-cell infiltrates, factors involved in B-cell recruitment, and lymphangiogenesis in renal interstitial injury (ie, acute and chronic interstitial nephritis and chronic IgA nephropathy). CD20-positive B cells formed a prominent part of the interstitial infiltrating cells. Together with CD3-positive T cells, the CD20-positive B cells formed larger nodular structures. CD10-positive pre-B cells were rare, and the majority were mature CD27-positive B cells. Proliferating B cells were detected within nodular infiltrates. The level of mRNA expression of the chemokine CXCL13 was increased and correlated with CD20 mRNA in the tubulointerstitial space. CXCL13 protein was predominantly found at sites of nodular infiltrates, in association with CXCR5-positive B cells. Furthermore, sites of chronic interstitial inflammation were associated with a high number of lymphatic vessels. B-cell infiltrates form a prominent part of the interstitial infiltrates both in primary interstitial lesions and in IgA nephropathy. CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system.

KW - Acute Disease

KW - Adolescent

KW - Adult

KW - Aged

KW - Antigens, CD

KW - B-Lymphocytes

KW - Chemokine CXCL13

KW - Chemokines, CXC

KW - Child

KW - Chronic Disease

KW - Female

KW - Glomerulonephritis, IGA

KW - Humans

KW - Lymphatic Vessels

KW - Male

KW - Middle Aged

KW - Nephritis, Interstitial

KW - Receptors, CXCR5

KW - Receptors, Chemokine

KW - T-Lymphocytes

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.2353/ajpath.2007.060554

DO - 10.2353/ajpath.2007.060554

M3 - SCORING: Journal article

C2 - 17255314

VL - 170

SP - 457

EP - 468

JO - AM J PATHOL

JF - AM J PATHOL

SN - 0002-9440

IS - 2

ER -