Research ExplorerPublicationsThe consequences of neonatal pain, stress and opiate adminis...

The consequences of neonatal pain, stress and opiate administration in animal models: an extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes

Standard

The consequences of neonatal pain, stress and opiate administration in animal models: an extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes. / Steinbauer, Philipp; Monje, Francisco J; Kothgassner, Oswald; Goreis, Andreas; Eva, Chwala; Wildner, Brigitte; Schned, Hannah; Deindl, Philipp; Seki, David; Berger, Angelika; Olischar, Monika; Giordano, Vito.

In: NEUROSCI BIOBEHAV R, Vol. 137, 104661, 06.2022.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Steinbauer, P, Monje, FJ, Kothgassner, O, Goreis, A, Eva, C, Wildner, B, Schned, H, Deindl, P, Seki, D, Berger, A, Olischar, M & Giordano, V 2022, 'The consequences of neonatal pain, stress and opiate administration in animal models: an extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes', NEUROSCI BIOBEHAV R, vol. 137, 104661. https://doi.org/10.1016/j.neubiorev.2022.104661

APA

Steinbauer, P., Monje, F. J., Kothgassner, O., Goreis, A., Eva, C., Wildner, B., Schned, H., Deindl, P., Seki, D., Berger, A., Olischar, M., & Giordano, V. (2022). The consequences of neonatal pain, stress and opiate administration in animal models: an extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes. NEUROSCI BIOBEHAV R, 137, [104661]. https://doi.org/10.1016/j.neubiorev.2022.104661

Vancouver

Steinbauer P, Monje FJ, Kothgassner O, Goreis A, Eva C, Wildner B et al. The consequences of neonatal pain, stress and opiate administration in animal models: an extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes. NEUROSCI BIOBEHAV R. 2022 Jun;137. 104661. https://doi.org/10.1016/j.neubiorev.2022.104661

Bibtex

@article{bc2d9227982f46e2a98c8d4c6afc7e16,
title = "The consequences of neonatal pain, stress and opiate administration in animal models: an extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes",
abstract = "This systematic review and meta-analysis aimed to investigate the association of neonatal exposure to pain, stress, opiate administration alone, as well as opiate administration prior to a painful procedure on neuronal cell death, motor, and behavioral outcomes in rodents. In total, 36 studies investigating the effect of pain (n=18), stress (n=15), opiate administration (n=13), as well as opiate administration prior to a painful event (n=7) in rodents were included in our meta-analysis. The results showed a large effect of pain (g = 1.37, 95% CI 1.00-1.74, p <.001) on neuronal cell death. Moreover, higher number of neonatal pain events were significantly associated with increased neuronal cell death, increased anxiety (b = -1.18, SE = 0.43, p =.006), and depressant-like behavior (b = 1.74, SE = 0.51, p =.027) in rodents. Both opiates and pain had no impact on motor function (g = 0.26, 95% CI 0.18-0.70, p =.248).",
author = "Philipp Steinbauer and Monje, {Francisco J} and Oswald Kothgassner and Andreas Goreis and Chwala Eva and Brigitte Wildner and Hannah Schned and Philipp Deindl and David Seki and Angelika Berger and Monika Olischar and Vito Giordano",
note = "Copyright {\textcopyright} 2022. Published by Elsevier Ltd.",
year = "2022",
month = jun,
doi = "10.1016/j.neubiorev.2022.104661",
language = "English",
volume = "137",
journal = "NEUROSCI BIOBEHAV R",
issn = "0149-7634",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - The consequences of neonatal pain, stress and opiate administration in animal models: an extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes

AU - Steinbauer, Philipp

AU - Monje, Francisco J

AU - Kothgassner, Oswald

AU - Goreis, Andreas

AU - Eva, Chwala

AU - Wildner, Brigitte

AU - Schned, Hannah

AU - Deindl, Philipp

AU - Seki, David

AU - Berger, Angelika

AU - Olischar, Monika

AU - Giordano, Vito

N1 - Copyright © 2022. Published by Elsevier Ltd.

PY - 2022/6

Y1 - 2022/6

N2 - This systematic review and meta-analysis aimed to investigate the association of neonatal exposure to pain, stress, opiate administration alone, as well as opiate administration prior to a painful procedure on neuronal cell death, motor, and behavioral outcomes in rodents. In total, 36 studies investigating the effect of pain (n=18), stress (n=15), opiate administration (n=13), as well as opiate administration prior to a painful event (n=7) in rodents were included in our meta-analysis. The results showed a large effect of pain (g = 1.37, 95% CI 1.00-1.74, p <.001) on neuronal cell death. Moreover, higher number of neonatal pain events were significantly associated with increased neuronal cell death, increased anxiety (b = -1.18, SE = 0.43, p =.006), and depressant-like behavior (b = 1.74, SE = 0.51, p =.027) in rodents. Both opiates and pain had no impact on motor function (g = 0.26, 95% CI 0.18-0.70, p =.248).

AB - This systematic review and meta-analysis aimed to investigate the association of neonatal exposure to pain, stress, opiate administration alone, as well as opiate administration prior to a painful procedure on neuronal cell death, motor, and behavioral outcomes in rodents. In total, 36 studies investigating the effect of pain (n=18), stress (n=15), opiate administration (n=13), as well as opiate administration prior to a painful event (n=7) in rodents were included in our meta-analysis. The results showed a large effect of pain (g = 1.37, 95% CI 1.00-1.74, p <.001) on neuronal cell death. Moreover, higher number of neonatal pain events were significantly associated with increased neuronal cell death, increased anxiety (b = -1.18, SE = 0.43, p =.006), and depressant-like behavior (b = 1.74, SE = 0.51, p =.027) in rodents. Both opiates and pain had no impact on motor function (g = 0.26, 95% CI 0.18-0.70, p =.248).

U2 - 10.1016/j.neubiorev.2022.104661

DO - 10.1016/j.neubiorev.2022.104661

M3 - SCORING: Review article

C2 - 35427643

VL - 137

JO - NEUROSCI BIOBEHAV R

JF - NEUROSCI BIOBEHAV R

SN - 0149-7634

M1 - 104661

ER -