The consequences of neonatal pain, stress and opiate administration in animal models: an extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes
Standard
The consequences of neonatal pain, stress and opiate administration in animal models: an extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes. / Steinbauer, Philipp; Monje, Francisco J; Kothgassner, Oswald; Goreis, Andreas; Eva, Chwala; Wildner, Brigitte; Schned, Hannah; Deindl, Philipp; Seki, David; Berger, Angelika; Olischar, Monika; Giordano, Vito.
in: NEUROSCI BIOBEHAV R, Jahrgang 137, 104661, 06.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The consequences of neonatal pain, stress and opiate administration in animal models: an extensive meta-analysis concerning neuronal cell death, motor and behavioral outcomes
AU - Steinbauer, Philipp
AU - Monje, Francisco J
AU - Kothgassner, Oswald
AU - Goreis, Andreas
AU - Eva, Chwala
AU - Wildner, Brigitte
AU - Schned, Hannah
AU - Deindl, Philipp
AU - Seki, David
AU - Berger, Angelika
AU - Olischar, Monika
AU - Giordano, Vito
N1 - Copyright © 2022. Published by Elsevier Ltd.
PY - 2022/6
Y1 - 2022/6
N2 - This systematic review and meta-analysis aimed to investigate the association of neonatal exposure to pain, stress, opiate administration alone, as well as opiate administration prior to a painful procedure on neuronal cell death, motor, and behavioral outcomes in rodents. In total, 36 studies investigating the effect of pain (n=18), stress (n=15), opiate administration (n=13), as well as opiate administration prior to a painful event (n=7) in rodents were included in our meta-analysis. The results showed a large effect of pain (g = 1.37, 95% CI 1.00-1.74, p <.001) on neuronal cell death. Moreover, higher number of neonatal pain events were significantly associated with increased neuronal cell death, increased anxiety (b = -1.18, SE = 0.43, p =.006), and depressant-like behavior (b = 1.74, SE = 0.51, p =.027) in rodents. Both opiates and pain had no impact on motor function (g = 0.26, 95% CI 0.18-0.70, p =.248).
AB - This systematic review and meta-analysis aimed to investigate the association of neonatal exposure to pain, stress, opiate administration alone, as well as opiate administration prior to a painful procedure on neuronal cell death, motor, and behavioral outcomes in rodents. In total, 36 studies investigating the effect of pain (n=18), stress (n=15), opiate administration (n=13), as well as opiate administration prior to a painful event (n=7) in rodents were included in our meta-analysis. The results showed a large effect of pain (g = 1.37, 95% CI 1.00-1.74, p <.001) on neuronal cell death. Moreover, higher number of neonatal pain events were significantly associated with increased neuronal cell death, increased anxiety (b = -1.18, SE = 0.43, p =.006), and depressant-like behavior (b = 1.74, SE = 0.51, p =.027) in rodents. Both opiates and pain had no impact on motor function (g = 0.26, 95% CI 0.18-0.70, p =.248).
U2 - 10.1016/j.neubiorev.2022.104661
DO - 10.1016/j.neubiorev.2022.104661
M3 - SCORING: Review article
C2 - 35427643
VL - 137
JO - NEUROSCI BIOBEHAV R
JF - NEUROSCI BIOBEHAV R
SN - 0149-7634
M1 - 104661
ER -