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The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed

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The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed. / Broocks, Gabriel; Meyer, Lukas; McDonough, Rosalie; Bechstein, Matthias; Hanning, Uta; Fiehler, Jens; Kemmling, Andre.

In: FRONT NEUROL, Vol. 12, 718046, 04.01.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Broocks, G, Meyer, L, McDonough, R, Bechstein, M, Hanning, U, Fiehler, J & Kemmling, A 2022, 'The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed', FRONT NEUROL, vol. 12, 718046. https://doi.org/10.3389/fneur.2021.718046

APA

Broocks, G., Meyer, L., McDonough, R., Bechstein, M., Hanning, U., Fiehler, J., & Kemmling, A. (2022). The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed. FRONT NEUROL, 12, [718046]. https://doi.org/10.3389/fneur.2021.718046

Vancouver

Broocks G, Meyer L, McDonough R, Bechstein M, Hanning U, Fiehler J et al. The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed. FRONT NEUROL. 2022 Jan 4;12. 718046. https://doi.org/10.3389/fneur.2021.718046

Bibtex

@article{5b3be9eee7d546db9242e02d9283f7a6,
title = "The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed",
abstract = "Randomized trials supporting the benefit of endovascular treatment in acute ischemic stroke patients with a large early infarction are not yet available. Few retrospective studies exist that suggest a potential positive treatment effect on functional outcome, as well as procedural safety. However, potential benefit or harm of MT in patients with low initial ASPECTS is still a subject of current debate, and in particular, how to select these patients for treatment. The purpose of this pilot study was to evaluate how early tissue water uptake in acute ischemic brain might determine lesion fate and functional outcome in low ASPECTS patients undergoing MT. We observed that the degree of early water uptake measured by quantitative NWU was significantly associated with functional outcome in low ASPECTS patients, yielding a higher diagnostic power compared to other parameters such as ASPECTS, age, or NIHSS. No conclusive evidence of a beneficial effect of successful reperfusion was observed in patients with low ASPECTS and high NWU, which highlights the potential of NWU as a tool to specify patient selection.",
author = "Gabriel Broocks and Lukas Meyer and Rosalie McDonough and Matthias Bechstein and Uta Hanning and Jens Fiehler and Andre Kemmling",
note = "Copyright {\textcopyright} 2022 Broocks, Meyer, McDonough, Bechstein, Hanning, Fiehler, Kemmling.",
year = "2022",
month = jan,
day = "4",
doi = "10.3389/fneur.2021.718046",
language = "English",
volume = "12",
journal = "FRONT NEUROL",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed

AU - Broocks, Gabriel

AU - Meyer, Lukas

AU - McDonough, Rosalie

AU - Bechstein, Matthias

AU - Hanning, Uta

AU - Fiehler, Jens

AU - Kemmling, Andre

N1 - Copyright © 2022 Broocks, Meyer, McDonough, Bechstein, Hanning, Fiehler, Kemmling.

PY - 2022/1/4

Y1 - 2022/1/4

N2 - Randomized trials supporting the benefit of endovascular treatment in acute ischemic stroke patients with a large early infarction are not yet available. Few retrospective studies exist that suggest a potential positive treatment effect on functional outcome, as well as procedural safety. However, potential benefit or harm of MT in patients with low initial ASPECTS is still a subject of current debate, and in particular, how to select these patients for treatment. The purpose of this pilot study was to evaluate how early tissue water uptake in acute ischemic brain might determine lesion fate and functional outcome in low ASPECTS patients undergoing MT. We observed that the degree of early water uptake measured by quantitative NWU was significantly associated with functional outcome in low ASPECTS patients, yielding a higher diagnostic power compared to other parameters such as ASPECTS, age, or NIHSS. No conclusive evidence of a beneficial effect of successful reperfusion was observed in patients with low ASPECTS and high NWU, which highlights the potential of NWU as a tool to specify patient selection.

AB - Randomized trials supporting the benefit of endovascular treatment in acute ischemic stroke patients with a large early infarction are not yet available. Few retrospective studies exist that suggest a potential positive treatment effect on functional outcome, as well as procedural safety. However, potential benefit or harm of MT in patients with low initial ASPECTS is still a subject of current debate, and in particular, how to select these patients for treatment. The purpose of this pilot study was to evaluate how early tissue water uptake in acute ischemic brain might determine lesion fate and functional outcome in low ASPECTS patients undergoing MT. We observed that the degree of early water uptake measured by quantitative NWU was significantly associated with functional outcome in low ASPECTS patients, yielding a higher diagnostic power compared to other parameters such as ASPECTS, age, or NIHSS. No conclusive evidence of a beneficial effect of successful reperfusion was observed in patients with low ASPECTS and high NWU, which highlights the potential of NWU as a tool to specify patient selection.

U2 - 10.3389/fneur.2021.718046

DO - 10.3389/fneur.2021.718046

M3 - SCORING: Journal article

C2 - 35095708

VL - 12

JO - FRONT NEUROL

JF - FRONT NEUROL

SN - 1664-2295

M1 - 718046

ER -