The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed
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The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed. / Broocks, Gabriel; Meyer, Lukas; McDonough, Rosalie; Bechstein, Matthias; Hanning, Uta; Fiehler, Jens; Kemmling, Andre.
in: FRONT NEUROL, Jahrgang 12, 718046, 04.01.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - The Benefit of Thrombectomy in Patients With Low ASPECTS Is a Matter of Shades of Gray-What Current Trials May Have Missed
AU - Broocks, Gabriel
AU - Meyer, Lukas
AU - McDonough, Rosalie
AU - Bechstein, Matthias
AU - Hanning, Uta
AU - Fiehler, Jens
AU - Kemmling, Andre
N1 - Copyright © 2022 Broocks, Meyer, McDonough, Bechstein, Hanning, Fiehler, Kemmling.
PY - 2022/1/4
Y1 - 2022/1/4
N2 - Randomized trials supporting the benefit of endovascular treatment in acute ischemic stroke patients with a large early infarction are not yet available. Few retrospective studies exist that suggest a potential positive treatment effect on functional outcome, as well as procedural safety. However, potential benefit or harm of MT in patients with low initial ASPECTS is still a subject of current debate, and in particular, how to select these patients for treatment. The purpose of this pilot study was to evaluate how early tissue water uptake in acute ischemic brain might determine lesion fate and functional outcome in low ASPECTS patients undergoing MT. We observed that the degree of early water uptake measured by quantitative NWU was significantly associated with functional outcome in low ASPECTS patients, yielding a higher diagnostic power compared to other parameters such as ASPECTS, age, or NIHSS. No conclusive evidence of a beneficial effect of successful reperfusion was observed in patients with low ASPECTS and high NWU, which highlights the potential of NWU as a tool to specify patient selection.
AB - Randomized trials supporting the benefit of endovascular treatment in acute ischemic stroke patients with a large early infarction are not yet available. Few retrospective studies exist that suggest a potential positive treatment effect on functional outcome, as well as procedural safety. However, potential benefit or harm of MT in patients with low initial ASPECTS is still a subject of current debate, and in particular, how to select these patients for treatment. The purpose of this pilot study was to evaluate how early tissue water uptake in acute ischemic brain might determine lesion fate and functional outcome in low ASPECTS patients undergoing MT. We observed that the degree of early water uptake measured by quantitative NWU was significantly associated with functional outcome in low ASPECTS patients, yielding a higher diagnostic power compared to other parameters such as ASPECTS, age, or NIHSS. No conclusive evidence of a beneficial effect of successful reperfusion was observed in patients with low ASPECTS and high NWU, which highlights the potential of NWU as a tool to specify patient selection.
U2 - 10.3389/fneur.2021.718046
DO - 10.3389/fneur.2021.718046
M3 - SCORING: Journal article
C2 - 35095708
VL - 12
JO - FRONT NEUROL
JF - FRONT NEUROL
SN - 1664-2295
M1 - 718046
ER -