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The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants

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The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants. / Hartz, Annika; Pagel, Julia; Humberg, Alexander; Preuss, Michael; Schreiter, Lena; Rupp, Jan; Figge, Julia; Karsten, Christian M; Nürnberg, Peter; Herting, Egbert; Göpel, Wolfgang; Härtel, Christoph; German Neonatal Network (GNN).

In: PLOS ONE, Vol. 12, No. 5, 2017, p. e0178032.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hartz, A, Pagel, J, Humberg, A, Preuss, M, Schreiter, L, Rupp, J, Figge, J, Karsten, CM, Nürnberg, P, Herting, E, Göpel, W, Härtel, C & German Neonatal Network (GNN) 2017, 'The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants', PLOS ONE, vol. 12, no. 5, pp. e0178032. https://doi.org/10.1371/journal.pone.0178032

APA

Hartz, A., Pagel, J., Humberg, A., Preuss, M., Schreiter, L., Rupp, J., Figge, J., Karsten, C. M., Nürnberg, P., Herting, E., Göpel, W., Härtel, C., & German Neonatal Network (GNN) (2017). The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants. PLOS ONE, 12(5), e0178032. https://doi.org/10.1371/journal.pone.0178032

Vancouver

Hartz A, Pagel J, Humberg A, Preuss M, Schreiter L, Rupp J et al. The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants. PLOS ONE. 2017;12(5):e0178032. https://doi.org/10.1371/journal.pone.0178032

Bibtex

@article{e6523ffff8354633a30587c0f7cca7ad,
title = "The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants",
abstract = "OBJECTIVES: Studies on the influence of mannose-binding lectin (MBL) deficiency on infection susceptibility in preterm infants have yielded controversial results. We investigated the association of genotype-based MBL levels with outcome in very-low-birth weight infants (VLBWI).METHODS: We genotyped 3 genetic variants of MBL2 (rs1800450, rs1800451, rs5030737) in 6878 VLBWI. MBL plasma levels were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary outcome was the effect of genotype-based MBL2 levels on blood-culture proven and clinical sepsis during primary stay in hospital. We also evaluated burden of infection within 24 months after discharge.RESULTS: We found no association between MBL levels and sepsis risk in the whole cohort. Infants without measurable MBL levels born between 32 0/7 to 36 6/7 weeks of gestation, however, had a higher rate of Gram-negative sepsis than infants with normal or reduced MBL levels. In a follow-up investigation at 24 months (n = 1070 infants), infants without measurable MBL levels suffered more frequently from stomatitis and urinary tract infection.CONCLUSIONS: In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.",
keywords = "Cohort Studies, Humans, Infant, Newborn, Infant, Very Low Birth Weight, Infections/complications, Mannose-Binding Lectin/deficiency, Mannose-Binding Lectins/genetics, Metabolism, Inborn Errors/complications, Polymorphism, Genetic",
author = "Annika Hartz and Julia Pagel and Alexander Humberg and Michael Preuss and Lena Schreiter and Jan Rupp and Julia Figge and Karsten, {Christian M} and Peter N{\"u}rnberg and Egbert Herting and Wolfgang G{\"o}pel and Christoph H{\"a}rtel and {German Neonatal Network (GNN)}",
year = "2017",
doi = "10.1371/journal.pone.0178032",
language = "English",
volume = "12",
pages = "e0178032",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

RIS

TY - JOUR

T1 - The association of mannose-binding lectin 2 polymorphisms with outcome in very low birth weight infants

AU - Hartz, Annika

AU - Pagel, Julia

AU - Humberg, Alexander

AU - Preuss, Michael

AU - Schreiter, Lena

AU - Rupp, Jan

AU - Figge, Julia

AU - Karsten, Christian M

AU - Nürnberg, Peter

AU - Herting, Egbert

AU - Göpel, Wolfgang

AU - Härtel, Christoph

AU - German Neonatal Network (GNN)

PY - 2017

Y1 - 2017

N2 - OBJECTIVES: Studies on the influence of mannose-binding lectin (MBL) deficiency on infection susceptibility in preterm infants have yielded controversial results. We investigated the association of genotype-based MBL levels with outcome in very-low-birth weight infants (VLBWI).METHODS: We genotyped 3 genetic variants of MBL2 (rs1800450, rs1800451, rs5030737) in 6878 VLBWI. MBL plasma levels were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary outcome was the effect of genotype-based MBL2 levels on blood-culture proven and clinical sepsis during primary stay in hospital. We also evaluated burden of infection within 24 months after discharge.RESULTS: We found no association between MBL levels and sepsis risk in the whole cohort. Infants without measurable MBL levels born between 32 0/7 to 36 6/7 weeks of gestation, however, had a higher rate of Gram-negative sepsis than infants with normal or reduced MBL levels. In a follow-up investigation at 24 months (n = 1070 infants), infants without measurable MBL levels suffered more frequently from stomatitis and urinary tract infection.CONCLUSIONS: In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.

AB - OBJECTIVES: Studies on the influence of mannose-binding lectin (MBL) deficiency on infection susceptibility in preterm infants have yielded controversial results. We investigated the association of genotype-based MBL levels with outcome in very-low-birth weight infants (VLBWI).METHODS: We genotyped 3 genetic variants of MBL2 (rs1800450, rs1800451, rs5030737) in 6878 VLBWI. MBL plasma levels were categorized as normal (wild type, A/A), low (heterozygotes, A/O) or undetectable (homozygotes, O/O). Primary outcome was the effect of genotype-based MBL2 levels on blood-culture proven and clinical sepsis during primary stay in hospital. We also evaluated burden of infection within 24 months after discharge.RESULTS: We found no association between MBL levels and sepsis risk in the whole cohort. Infants without measurable MBL levels born between 32 0/7 to 36 6/7 weeks of gestation, however, had a higher rate of Gram-negative sepsis than infants with normal or reduced MBL levels. In a follow-up investigation at 24 months (n = 1070 infants), infants without measurable MBL levels suffered more frequently from stomatitis and urinary tract infection.CONCLUSIONS: In a large cohort of VLBWI MBL2 deficiency had no major impact on infection risk unless children were born between 32 0/7 and 36 6/7 weeks of gestation.

KW - Cohort Studies

KW - Humans

KW - Infant, Newborn

KW - Infant, Very Low Birth Weight

KW - Infections/complications

KW - Mannose-Binding Lectin/deficiency

KW - Mannose-Binding Lectins/genetics

KW - Metabolism, Inborn Errors/complications

KW - Polymorphism, Genetic

U2 - 10.1371/journal.pone.0178032

DO - 10.1371/journal.pone.0178032

M3 - SCORING: Journal article

C2 - 28558032

VL - 12

SP - e0178032

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 5

ER -